Statins - the Holy Grail for cancer? (original) (raw)

Statins, widely prescribed for cardiovascular disease prevention, may also have antineoplastic effects through HMG-CoA reductase-dependent and independent pathways. Epidemiological evidence suggests that statin use is associated with reduced cancer-related mortality across several cancer types, although the biological mechanisms and potential for statins as cancer treatment require further investigation. Despite promising findings, the lack of consistent doseresponse relationship and concerns regarding generalizability emphasize the need for well-designed clinical trials aimed at establishing the efficacy of statins in cancer outcomes.