Association between erectile dysfunction and cardiovascular risk in individuals with type-2 diabetes without overt cardiovascular disease (original) (raw)
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Erectile Dysfunction and Various Cardiovascular Risk Factors in Diabetic Males- A Continued Study
National journal of integrated research in medicine, 2016
Background: Erectile dysfunction is a prevalent health problem among diabetics. Presence of erectile dysfunction in diabetics mandates evaluation for coronary artery disease risk factors. Methodology: This case control hospital based study involved 102 patients evaluated for coronary artery disease risk factors by using IIEF-5 questionnaire at Upgraded P.G. Department of Medicine, M.L.N. Medical College, and SRN Hospital, Allahabad after taking informed consent and intuitional ethical committee permission. Suitable statistical tests were applied. Results: Seventy (68.3%) patients were found to have erectile dysfunction. Percentage of mild, mild to moderate, moderate and severe erectile dysfunction was 11.42, 25.71, 31.43 and 31.43 percent respectively. Age was found to be a significant determinant of erectile dysfunction in diabetics. Prevalence of hypertension was significantly higher among the cases as compared to controls. Conclusion: All diabetic males with erectile dysfunction should be intensively investigated for coronary artery disease and its risk factors.
Erectile Dysfunction Severity Might be Associated with Poor Cardiovascular Prognosis in Diabetic Men
The Journal of Sexual Medicine, 2007
Although erectile dysfunction (ED) might be associated with coronary heart disease (CHD), there is no evidence it predicts poor cardiovascular prognosis. On the other hand, an abnormal heart rate profile during exercise stress testing predicts poor cardiovascular prognosis in high-risk patients, such as diabetic men, even in the absence of CHD. In order to study if ED predicts poor cardiovascular prognosis in high-risk patients, we examined the association between ED and heart rate profile during exercise stress testing in diabetic men with no CHD. Erectile dysfunction severity, exercise capacity during exercise stress testing, and heart rate decrease after exercise stress testing. A retrospective study. The medical charts of diabetic men with vascular ED from a single-sex clinic were reviewed, as well as the medical charts of body mass index (BMI)- and age-matched diabetic men without ED going through routine check-ups. All men underwent routine treadmill stress testing according to the Bruce protocol in order to characterize heart rate profile during exercise. The Sexual Health Inventory for Men (SHIM) questionnaire was used to characterize ED. Included were 18 diabetic men with ED (SHIM questionnaire scores 5-21) and 18 diabetic men without ED (SHIM questionnaire scores 22-25), 40 years of age or older. None of the men had signs of coronary insufficiency during exercise treadmill stress testing. Although the two groups did not statistically differ with respect to the mean age, the mean BMI, the prevalence of cardiovascular risk factors, and the mean exercise treadmill stress testing findings, the SHIM questionnaire scores were significantly associated with low metabolic equivalents (r = 0.51, P = 0.03) and delayed heart rate recovery during the first 2 minutes after exercise (r = 0.55, P = 0.018) only among diabetic men with ED. Erectile dysfunction severity might be associated with poor cardiovascular prognosis in adult diabetic men with no CHD.
Erectile dysfunction (ED) is the persistent inability to attain /or maintain an erection of the penis adequate for satisfactory sexual intercourse. This condition has been found to be more common, to occur earlier and to be more difficult to treat in men with Diabetes mellitus (DM) than those without DM. However, recent developments have led to improvement in the treatment of this condition with attendant reduction in associated psychosocial problems. This review article discusses the various treatment strategies for ED in men with DM, brings to fore the need for prior assessment of cardiovascular status of such patients before commencement of treatment for ED as well as the need for adequate glycaemic control and treatment of other co-morbidities in these patients.
Circulation, 2004
Background— Erectile dysfunction (ED) is associated with coronary artery disease (CAD). In diabetic patients, CAD is often silent. Among diabetic patients with silent CAD, the prevalence of ED has never been evaluated. We investigated whether ED is associated with asymptomatic CAD in type 2 diabetic patients. Methods and Results— We evaluated the prevalence of ED in 133 uncomplicated diabetic men with angiographically verified silent CAD and in 127 diabetic men without myocardial ischemia at exercise ECG, 48-hour ambulatory ECG, and stress echocardiography. The groups were comparable for age and diabetes duration. Patients were screened for ED using the validated International Index of Erectile Function (IIEF-5) questionnaire. The prevalence of ED was significantly higher in patients with than in those without silent CAD (33.8% versus 4.7%; P =0.000). Multiple logistic regression analysis showed that ED, apolipoprotein(a) polymorphism, smoking, microalbuminuria, HDL, and LDL were si...
Erectile dysfunction and angiographic extent of coronary artery disease in type II diabetic patients
International Journal of Impotence Research, 2006
Some studies observed an association between erectile dysfunction (ED) and coronary artery disease (CAD) extent in the general population, but others did not. There are no specific studies in diabetic populations. The aim of the present study was to evaluate whether ED is correlated with the extent of angiographic CAD in a large group of type II diabetic patients. We recruited 198 consecutive type II diabetic males undergoing an elective coronary angiography to evaluate chest pain or suspected CAD. Presence and degree of ED were assessed by the International Index Erectile Function -5 (IIEF-5) questionnaire. ED was considered present, when IIEF-5 score was p21. Moreover, each domain of IIEF-5 was considered. Angiographic CAD extent was expressed both by the number of vessels diseased and by the Gensini scoring system. The percentage of subjects with ED was significantly higher (45.8 versus 15.8%; P ¼ 0.0120) in patients with (n ¼ 179) than in those without (n ¼ 19) significant angiographic CAD (stenosis of the lumen X50%). No significant association of CAD extent with presence of ED, total IIEF-5 score and each domain of IIEF-5 was observed. Our study shows that ED was significantly more prevalent in type II diabetic males with angiographic CAD than in those with normal arteries. However, no correlation was found between the extent of angiographic CAD and the presence or the severity of ED.
American Heart Journal, 2012
Multiple published studies have established erectile dysfunction (ED) as an independent risk marker for cardiovascular disease (CVD). In fact, incident ED has a similar or greater predictive value for cardiovascular events than traditional risk factors including smoking, hyperlipidemia, and family history of myocardial infarction. Here, we review evidence that supports ED as a particularly significant harbinger of CVD in 2 populations: men b60 years of age and those with diabetes. Although addition of ED to the Framingham Risk Score only modestly improved the 10-year predictive capacity of the Framingham Risk Score for myocardial infarction or coronary death data in men enrolled in the Massachusetts Male Aging Study, other epidemiologic studies suggest that the predictive value of ED is quite strong in younger men. Indeed, in the Olmstead County Study, men 40 to 49 years of age with ED had a 50-fold higher incidence of new-incident coronary artery disease than those without ED. However, ED had less predictive value (5-fold increased risk) for coronary artery disease in men 70 years and older. Several studies, including a large analysis of more than 6300 men enrolled in the ADVANCE study, suggest that ED is a particularly powerful predictor of CVD in diabetic men as well. Based on the literature reviewed here, we encourage physicians to inquire about ED symptoms in all men more than 30 years of age with cardiovascular risk factors. Identification of ED, particularly in men b60 years old and those with diabetes, represents an important first step toward CVD risk detection and reduction.
Association Between Erectile Dysfunction and Cardiovascular Disease: A Systematic Review
Chattagram Maa-O-Shishu Hospital Medical College Journal
Erectile Dysfunction (ED) describes the persistent inability to achieve or maintain a penile erection for adequate sexual performance. ED is thought to be a vascular disease affecting more than 70% of men with (Cardiovascular Disease) CVD and sharing a myriad of risk factors like hypertension, smoking, diabetes, obesity, ageing and the metabolic syndrome. Diabetes increases the risk of both ED and CVD with the latter being the leading cause of death. Endothelial dysfunction and its role in the development of atherosclerosis may be the common link between ED, CVD and diabetes. With the current epidemic of type 2 diabetes, diabetes related CVD will increase in tandem. Early identification of this risk group is therefore paramount. Evidence has shown that ED is an independent marker of increased CVD risk and heralds the onset of coronary artery disease, peripheral arterial disease and stroke thereby providing a window of opportunity for risk factor modification. In our paper we shall e...