The I1307K APC mutation in a high-risk clinic setting: a follow-up study (original) (raw)

This study investigates the natural history of colonic neoplasia in Jewish I1307K APC mutation carriers identified in a high-risk familial cancer clinic. Out of 51 identified carriers, 29 were interviewed over a follow-up period of 0.5-5 years. The findings indicate a low short-term risk for colonic polyps, primarily affecting those with pre-existing colon tumors, while noting a potential relationship between breast and colorectal cancer. Limitations include a small sample size and incomplete follow-up data, suggesting the need for further research to draw definitive conclusions.