Antibacterial Surfaces for Biomedical Applications (original) (raw)
Medical devices such as orthopedic implants are intended to serve for improved quality of life. However, clinical success cannot be taken for granted and the most common reason for failure is due to biomaterials associated infection (BAI). An implantation surgical site is a susceptible environment for bacterial colonization, which in combination with compromised immune system, results in that bacteria can develop biofilms on the implant surface or in adjacent tissue. Once such a biofilm has established, it may lead to an infection that cannot be eradicated by means of traditional antibiotics, often resulting in revision surgery. Wounds after post implantation surgery is another risk for bacterial colonization into underlying tissue and increases further the susceptibility to infection. These and other bacteria related complications are today becoming more serious due to the rapid increase of antibiotic resistance worldwide. This has resulted in that many available antibiotics are lo...
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