Glucose levels are not the same for everyone: A real-world big data study evaluating glucose levels by sex and age among children (original) (raw)
Related papers
A Real-world Big Data Study Evaluating Glucose Levels by Sex and Age Among Healthy Children
2022
Purpose: To assess the distribution of glucose levels by age and sex in healthy children using a large-scale population-based cohort.Methods: A retrospective study with real-world de-identified data from a large, state mandated health fund in Israel among healthy children aged 2 to 18 years old between 2006 and 2019. Age, sex, and BMI differences in mean glucose levels were evaluated using 3-way Anova.Results: Study included 130,170 blood samples from 117,411 children, 53.3% were female. After adjusting for ager boys had higher glucose levels than girls, with a mean of 89.21 ±8.66 mg/dL vs. 87.59 ±8.35 (p<0.001). Compared to the 15 to 18 year-olds (88.49 mg/dl ±7.63), 2 to 5 year-olds had lower glucose levels (84.19 ±10.65, (p<0.001)), 11 to 14 year-olds had higher glucose (90.40 ±7.42 (p<0.001)) and 6 to 10 year-olds showed no difference (88.45 ±8.25). Among our cohort, 33.0% (n=42,991) had a BMI percentile record the same year as their glucose test result. There was a wea...
Glucose Dysregulation in Obese Children: Predictive, Risk, and Potential Protective Factors*
Obesity, 2007
XEKOUKI, PARASKEVI, NIKOLETA M. NIKOLAKOPOULOU, ANNA PAPAGEORGIOU, SARANTIS LIVADAS, ANTONIS VOUTETAKIS, MARIA-ALEXANDRA MAGIAKOU, GEORGE P. CHROUSOS, BESSIE E. SPILIOTIS, AND CATHERINE DACOU-VOUTETAKIS. Glucose dysregulation in obese children: predictive, risk, and potential protective factors. Obesity. 2007;15:860 -869.
Diabetologia, 2010
Aims/hypothesis We aimed to examine whether sex differences in fasting plasma glucose (FPG), 2 h post-OGTT plasma glucose (2hPG) and HbA 1c could be explained by differences in body size and/or body composition between men and women in a general non-diabetic Danish population. Moreover, we aimed to study to what degree the newly suggested high-risk HbA 1c criteria overlapped with the current OGTT-based criteria of glucose intolerance. Methods We used cross-sectional data from 6,006 nondiabetic men and women. HbA 1c and FPG levels were measured and a 75 g OGTT was performed in all individuals. Height, weight and waist and hip circumferences were measured and BMI was calculated. Data were analysed in age-adjusted linear regression models. Results Men had higher FPG and HbA 1c levels than women, and women had higher 2hPG levels than men. Sex differences in 2hPG levels were explained by differ-ences in height and FPG levels, but sex differences in FPG or HbA 1c levels were not explained by anthropometric measures. Among individuals with HbA 1c in the high-risk range (6.0-6.5%), 73% had normal glucose tolerance. Conclusions/interpretation Sex differences in 2hPG levels after an OGTT may to some extent be a consequence of giving the same amount of glucose to individuals with different body size. In contrast, sex differences in FPG and HbA 1c levels are likely to have a true physiological basis. In clinical practice, the HbA 1c assay may be more convenient than the OGTT, but it is important to note that different populations are identified by the two methods.
Diabetology & metabolic syndrome, 2014
Adolescence, due to transient pubertal insulin resistance (IR), is associated with a higher risk for disturbances of glucose metabolism. The aim of our study was 1) to investigate the prevalence of disturbances of glucose metabolism, 2) to define gender specific homeostasis model assessment of insulin resistance (HOMA-IR) thresholds associated with increased cardiometabolic risks and 3) to provide predictors of HOMA-IR. The studied cohort consisted of Czech adolescents aged 13.0-17.9 years: 1,518 individuals of general population and three studied groups according weight category (615 normal weight, 230 overweight and 683 obese). The prevalence of IR, impaired fasting glucose (IFG) and type 2 diabetes was assessed. Risky HOMA-IR thresholds based on components of metabolic syndrome were investigated. HOMA-IR prediction was calculated taking into account age, blood pressure, multiple anthropometric, biochemical and hormonal parameters. In general population cohort, the prevalence of I...
Prevalence of elevated 1-h plasma glucose and its associations in obese youth
Diabetes Research and Clinical Practice, 2016
We found that in obese youth, plasma glucose above 155 mg/dl (8.6 mmol/l) at 60 min of an OGTT, a predictor of type 2 diabetes (T2D) in adults, was present in 12% with normal glucose tolerance and 57% with impaired glucose tolerance. Performance of elevated 1-h glucose in predicting T2D in overweight youngsters should be tested.