Depression and anxiety symptoms in Spanish adult patients with cystic fibrosis: associations with health-related quality of life (original) (raw)

2016, General Hospital Psychiatry

Background: Cystic fibrosis (CF) is a chronic disease with an impact on the quality of life. Self-reported symptoms of depression and anxiety were assessed in the Spanish cohort of the International Epidemiological Study on Depression and Anxiety in patients with CF (International Depression-Anxiety Epidemiological Study) and their relationship with health status and health-related quality of life (HRQoL) was evaluated. Methods: This cross-sectional study recruited adult patients with CF at 10 Spanish centers. Patients completed the Hospital Anxiety and Depression Scale (HADS) and the Revised Cystic Fibrosis Questionnaire. Demographic and health data were recorded from medical charts. Logistic regression was used to determine the predictors of elevated symptoms of depression and anxiety (HADS≥8). Results: Of the 336 participants recruited (mean age, 28.1 years; 48.2% women), 41 (12.2%) had elevated depression-related scores, and 100 (29.7%) had elevated anxiety-related scores (HADS≥8). After adjusting for confounders, only less education, intravenous antibiotics, psychiatric medications and psychotherapy were significantly associated with elevated psychological symptoms. Specifically, regardless of lung function, patients who were depressed or anxious reported worse HRQoL. General Hospital Psychiatry xxx (2016) xxx-xxx ☆ Conflicts of Interest: None of the authors has any conflict of interest to disclose. ☆☆ Ethical Approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. ☆☆☆ Study protocols were approved by local ethics committees at all CF centers. ★ Informed Consent: Informed consent was obtained from all individual participants included in the study. ★★ Patients' Data Protection: The authors declare that they have followed the protocols of their work center on the publication of patient data. ★★★ Statement of Authorship: Quittner A, Olveira C, and Olveira G: contributed to the conception and design of the study; Olveira C, and Olveira G contributed to the acquisition, analysis and interpretation of the data; and statistical analysis and drafting of the manuscript. Both authors (Olveira C and Olveira G) are the guarantor of the paper, taking responsibility for the integrity of the work as a whole from inception to published article. Sole A, Girón RM, Quintana-Gallego E, Mondejar P, Baranda F, Alvarez A, Prados C, Rodríguez-González J, Herrero-Labarga I contributed to data acquisition and critical revision of the manuscript.