A biomimetic approach towards synthesis of zinc oxide nanoparticles (original) (raw)
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Biomedical Potential of Zinc Oxide Nanoparticles Synthesized using Plant Extracts
SciDoc Publishers, 2021
Enhancement of plant materials based nanoparticles have various benefits over conventional physico-chemical methods. These conventional methods for example chemical reduction process, in which different chemicals hazardous are used for the synthesis of nanoparticles. Due hazardous, later converted to responsible for immeasurable health risks to environment due to their toxicity nature and threatening serious fears for human being. Plant based nanoparticle synthesis have many advantages and it will be useful to medicine and biological application. In this review, zinc oxide nanoparticles (ZnO NPs) by plants and their biomedical potential was covered. Many plants mediated (green synthesis) ZnO NPs has strong antimicrobial activity against the pathogens compared to available standard drugs and Antiviral, anticancer and free radical scavenging potential application. The plant based synthesis of ZnO NPs could be outstanding policy to develop resourceful and environmental friendly biomedical application.
BioNanoScience, 2017
The zinc oxide (ZnO) nanoparticles were successfully synthesized by using aqueous extracts of Aloe vera gel/leaf and Hibiscus sabdariffa leaf, and characterized by FT IR, UV-Vis, XRD, SEM, and EDX techniques. For comparison purposes, ZnO nanoparticles was also synthesized by chemical method. Phytochemical screening of the A. vera gel and leaf and H. sabdariffa leaf extracts showed the presence of alkaloids, carbohydrates, flavonoids, gums and mucilages, saponins, phenolic compounds, tannins, and terpenoids. FT IR spectra showed the presence of functional groups and protein as the stabilizing agent surrounding the ZnO nanoparticles. UV-Vis spectra of ZnO nanoparticles exhibit the characteristic absorption band in the range of 344-360 nm, which can be assigned to the intrinsic bandgap absorption of ZnO due to the electron transitions from the valence band to the conduction band. Powder XRD patterns confirmed the hexagonal wurtzite structure. Further, the SEM analysis also indicates the hexagonal rod shape structure of the ZnO nanoparticles. EDX spectra confirmed the chemical composition of the ZnO nanoparticles synthesized by both biological and chemical methods. In vitro antibacterial activity of ZnO nanoparticles synthesized by both biological and chemical methods were performed on three Gram (−ve) (Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa) and one Gram (+ve) (Staphylococcus aureus) bacteria, in which the ZnO nanoparticles obtained by biological method showed excellent bactericidal activity over that obtained by chemical method. All the ZnO nanoparticles showed promising antioxidant activity determined by five different methods such as 2,2′-azino-bis(3ethylbenzothiazoline-6-sulphonic acid) (ABTS); 2,2′-diphenyl-1-picrylhydrazyl (DPPH); hydrogen peroxide (H 2 O 2); superoxide radical scavenging; and hydroxyl radical scavenging assays. In vitro cytotoxicity of the ZnO nanoparticles were tested against three cancerous cell lines such as human breast adenocarcinoma (MCF-7), cervical (HeLa) and epithelioma (Hep-2), and one normal human dermal fibroblasts (NHDF) cell lines by MTT assay. Apoptosis induction was further confirmed by flow cytometry and cell cycle arrest. The ZnO nanoparticles obtained by biological method display remarkable cytotoxicity against the MCF-7 cell line, and found to be more potent than the widely used drug cisplatin.
Phytochemical Substances —Mediated Synthesis of Zinc Oxide Nanoparticles (ZnO NPS)
Artemisia absinthium (A. absinthium) leaf extract was successfully used to create zinc oxide nanoparticles (ZnO NPs), and their properties were investigated via several techniques, including X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray (EDX), Fourier transform infrared (FTIR), and UV–Vis spectroscopy. SEM analysis confirmed the spherical and elliptical shapes of the particles. Three different zinc peaks were observed via EDX at energies of 1, 8.7, and 9.8 keV, together with a single oxygen peak at 0.5 keV. XRD analysis identified ZnO NPs as having a hexagonal wurtzite structure with a particle size that decreased from 24.39 to 18.77 nm, and with an increasing surface area (BET) from 4.003 to 6.032 m2/g for the ZnO (without extract) and green ZnO NPs, respectively. FTIR analysis confirmed the groups of molecules that were accountable for stabilizing and minimizing the ZnO NPs, which was apparent at 3400 cm. Using UV–Vis spectroscopy, the band g...
Molecules, 2022
Nanomaterial is a rapidly growing area that is used to create a variety of new materials and nanotechnology applications from medical, pharmaceuticals, chemical, mechanical, electronics and several environmental industries including physical, chemical and biological nanoparticles are very important in our daily life. Nanoparticles with leaf extract from the healthy plant are important in the area of research using biosynthesis methods. Because of it’s used as an environmentally ecofriendly, other than traditional physical and chemical strategies. In particular, biologically synthesized nanoparticles have become a key branch of nanotechnology. The present work presents a synthesis of zinc oxide nanoparticles using an extract from the Argemone leaf Mexicana. Biosynthetic nanoparticles are characterized by X-ray diffraction (XRD), Ultraviolet visible (UV-vis) spectroscopy analysis, a Fourier Transform Infrared Spectroscopy analysis (FTIR) and a scanning electron microcopy (SEM), X-ray ...
Antioxidants
The green synthesis of zinc oxide nanoparticles (ZnO NPs) using a diverse range of plant species has been extensively reported. Despite the success achieved by biogenic synthesis, there are problems with the control and prediction of the properties of ZnO NPs, due to phytochemical diversity between plant species. In this sense, the main objective of our work was to investigate the effect of the antioxidant activity (AA) of plant extracts on the physicochemical characteristics of ZnO NPs (production yield, chemical composition, polydispersity index (PDI), surface charge (ζ-potential) and average particle size). In order to accomplish this objective, four plant extract with different antioxidant activities were used: Galega officinalis, Buddleja globosa, Eucalyptus globulus, and Aristotelia chilensis. Phytochemical screening, quantitative analysis of phenolic compounds and antioxidant activity determination of the different extracts were carried out. Chemical species such as catechin,...
Plant mediated-green synthesis of zinc oxide nanoparticles: An insight into biomedical applications
Nanotechnology Reviews
Green synthesis of zinc oxide (ZnO) nanoparticles (NPs) using various plant extracts as reducing and capping agents has gained attention in recent research. The green synthesis of ZnO NPs offers several advantages such as being simple, eco-friendly, safe, cost-effective, and reproducible approach with high stability. Hence, this article provides an overview of zinc metal and ZnO compounds, and traditional chemical and physical synthesis of ZnO NPs with primary focuses on the green synthesis of ZnO NPs. This study discusses various plant extracts used and the proposed mechanisms in the green synthesis of ZnO NPs. Additionally, it explores the cytotoxic mechanisms of the green-synthesized ZnO NPs and addresses the various biomedical applications of ZnO NPs, including antibacterial, anticancer, antidiabetic, antioxidant, antifungal, antiviral, antiparasitic, anti-inflammatory, and wound healing. Moreover, the review critically discusses the toxicity of ZnO NPs and emphasizes the need f...
. A Review on Synthesis of ZnO nanoparticles using plant extract
A range of engineering materials are considered a great deal for their properties in their nano form. Surface activity in nano form is increases diverse than in bulk form due to increased surface area. The nanosized inorganic components can exhibit interesting size-dependent properties, such as optical and electrical properties. Zinc oxide (ZnO) nanoparticles (or quantum dots), among nanosized metal oxides are of great interest and have been extensively investigated recently. ZnO nanoparticles has a wide band gap (3.4 eV) and large exciton binding energy (60 meV). ZnO nanoparticles, also shows visible light transmittance, UV absorption, and moderately high refractive index [12]. So they are found to be useful in a broad range of applications such as optoelectronic devices, dye-sensitized solar cells, catalysts, and sensors. There are several works on syntheses, physicochemical properties, and applications of ZnO nanoparticles.
Nanomaterials
Metal oxide nanoparticles (NPs), such as zinc oxide (ZnO), have been researched extensively for applications in biotechnology, photovoltaics, photocatalysis, sensors, cosmetics, and pharmaceuticals due to their unique properties at the nanoscale. ZnO NPs have been fabricated using conventional physical and chemical processes, but these techniques are limited due to the use of hazardous chemicals that are bad for the environment and high energy consumption. Plant-mediated synthesis of ZnO NPs has piqued the interest of researchers owing to secondary metabolites found in plants that can reduce Zn precursors and stabilise ZnO NPs. Thus, plant-mediated synthesis of ZnO NPs has become one of the alternative green synthesis routes for the fabrication of ZnO NPs. This is attributable to its environmental friendliness, simplicity, and the potential for industrial-scale expansion. Southern Africa is home to a large and diverse indigenous medicinal plant population. However, the use of these ...
A REVIEW STUDY OFZINC OXIDE NANOPARTICLES SYNTHESIS FROM PLANT EXTRACTS
GCTL, 2017
The development of nanotechnology is making the interest of researchers towards the synthesis of nanoparticles for bioapplication. In recent years, metal oxides such as ZnO have received increasing attention as antibacterial materials because of their stability under harsh processing conditions. They are generally regarded as safe materials for human beings and animals. Zinc activates 300 enzymes, and it plays a role in many other phenomena like growth, membrane stability, bone mineralization, tissue growth and repair, wound healing and cell signalling. Many studies have shown that ZnO nanoparticles have enhanced antibacterial activity. The use of plant and plant materials to synthesise Zinc nanoparticles is a relatively new and exciting research field. Various plants were used for the synthesis of nanoparticles using the green synthesis method. Nanoparticles were synthesized from all the plant parts separately like stem, flower, leaf, latex, root, peel, stem bark and fruits. The prepared Zinc oxide nanoparticles were characterized by using XRD, FTIR, UV-VIS Spectroscopy, EDAX, Particle size analyzer, TGA, and SEM. The objective of this review was to report on the synthesis of Zinc oxide nanoparticles by using different plant extracts and their significance in different fields.
Green synthesis of zinc oxide nanoparticles: a comparison
Green Chemistry Letters and Reviews, 2019
Green synthesis of nanoparticles by biological systems especially plant extracts has become an emerging field in nanotechnology. In this study, zinc oxide nanoparticles were synthesized using Laurus nobilis L. leaves aqueous extract and two different zinc salts (zinc acetate and zinc nitrate) as precursors. The synthesized nanoparticles were characterized by Ultraviolet-Visible spectroscopy (UV-Vis), Fourier Transform Infrared Spectroscopy (FT-IR), X-Ray Diffraction analysis (XRD), Energy-Dispersive X-ray analysis (EDX) and Scanning Electron Microscopy (SEM). UV-Vis spectra showed typical absorption peaks in around 350 nm due to their large excitation binding energy at room temperature. Chemical bond formations of zinc oxide were confirmed by FT-IR analyses. XRD results revealed the formation of hexagonal wurtzite structure, and SEM analyses showed spherical shape with the average size (21.49, 25.26) nm for the synthesized nanoparticles by zinc acetate and zinc nitrate respectively. EDX analyses confirmed high purity for the synthesized nanoparticles.