Pemphigus Vulgaris : case report (original) (raw)
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Considerations in Complications Arising from the Management of Pemphigus Vulgaris: A Case Report
Nigerian Journal of Dental Research
Background: This paper reports a case of pemphigus vulgaris in a middle-aged male with oral lesions and skin eruptions Objective: To highlight the complications of prolonged steroid therapy. Case Report A 48-year old male presented with an eight-month history of recurrent mouth ulcers. There was positive history of cutaneous ulcers on the upper extremities, back and genital areas. Patient had been placed on long term steroid therapy prescribed by general practitioners. General examination showed bilateral pitting pedal oedema, moon face and low blood pressure. Intra-oral examination revealed multiple irregular shaped ulcers and erosions with erythematous floor on the buccal mucosa, labial mucosa, floor of the mouth, soft palate and anterior pillar fauces. The dorsum of the tongue had areas of ulcerations with necrotic slough. An impression of pemphigus vulgaris was made based on high index of clinical suspicion and patient was commenced on azathioprine 50mg and prednisolone 40mg dai...
Pemphigus Vulgaris: A Case Report with Review of Literature
Journal of Indian Academy of Oral Medicine and Radiology, 2013
Pemphigus is a group of autoimmune diseases of the skin and/ or mucous membranes characterized histologically by intraepidermal blister, tombstone appearance of basal cells and immunopathologically by the finding of circulating immunoglobulin G (IgG) antibody directed against the cell surface of keratinocytes. Here, we report, case of pemphigus vulgaris, lesions in oral mucosa without any skin lesions. The condition improved with systemic corticosteroids along with adjuvant therapy. The purpose of this article is to emphasize the importance of early diagnosis of pemphigus, thereby decreasing the chances of fatality and improving the quality of life by various treatment modalities.
Pemphigus vulgaris: a case-based update
Journal (Canadian Dental Association), 2005
Pemphigus vulgaris (PV) is an autoimmune disease accounting for 80% of all cases of pemphigus. Before the advent of corticosteroid therapy, pemphigus was fatal, with a mortality rate of up to 75% in the first year. It is still a serious disorder, but the 5% to 10% mortality rate is now primarily due to the side effects of therapy. In 75% to 80% of cases, PV lesions first appear in the oral cavity. Dentists are therefore in a unique position to recognize the oral manifestations of the disease, allowing early diagnosis and initiation of treatment. The diagnosis is based on pathological examination and immunofluorescence testing. Systemic corticosteriods and steroid-sparing agents are the mainstays of treatment; topical corticosteroids may also be used to accelerate healing of persistent oral lesions. This article describes a 71-year-old woman with multiple chronic ulcers in the oral cavity, in whom PV was diagnosed 4 months after the symptoms first appeared. The article also reviews t...
Pemphigus vulgaris: a review of 12 cases
2015
duration and clinical course of the disease. Results: the mean age of the patients was 46.7 years; most of cases occurred in females (75.0 %); buccal mucosa was the site most frequently affected (83.3 %), and 25 % of cases showed extraoral manifestations. Erosion/ulceration was the most prevalent clinical appearance (83.3 %), and pain occurred in 100% of cases. The mean time of development of the lesions reported by the time of the diagnosis was 12.3 months, and the mean time of follow-up was 2 years. All patients received systemic therapy with prednisone, meanwhile in 58.3 % of cases it was associated with topic therapy and in 25 %, with systemic immunosuppressive therapy. One case (8.3 %) remained in remission regardless of the treatment withdrawal. Conclusion: Pemphigus vulgaris is a disease with important morbidity, which requires the attention of the dentist as a way to achieve early diagnosis.
IP innovative publication pvt ltd, 2020
Pemphigus is an autoimmune inter epidermal blistering disorder. it is characterized by mucosal and cutaneous vesicles, bullae, erosions. It has an array of maifesations and symptoms. Systemic corticosteroids have remained the mainstay of treatment for pemphigus, recent years are focusing on use of other immunomodulators as well. This review looks at the etiology, clinical features, management, complications of the condition.
A Comprehensive Review on Pemphigus Vulgaris
BJSTR, 2017
Pemphigus vulgaris is a life threatening chronic autoimmune disease characterized by the formation of intraepithelial blisters on the skin and mucous membranes. Pemphigus vulgaris initially manifests in the form of intraoral lesions which spread to other mucous membranes and the skin. Pemphigus vulgaris (PV), the most common and important variant, is an autoimmune blistering disease characterized by circulating pathogenic IgG (immunoglobin) antibodies against desmoglein 3 (Dsg3), about half the patients also having Dsg1 autoantibody. Oral lesions are initially vesiculobullous but readily rupture, new bullae developing as the older ones rupture and ulcerate. Biopsy of perilesional tissue, with histological and immune staining examinations, is essential to the diagnosis. The diagnosis is based on clinical findings and laboratory analyses, and it is usually treated by the combined administration of corticosteroids and immune suppressants. Detection of the oral lesions can result in an earlier diagnosis. The current review focuses on the etiopathogenesis, diagnosis and current treatment of pemphigus vulgaris.
Pemphigus Vulgaris-A Case Report
IOSR Journals , 2019
Pemphigus is a term derived from the Greek word Pemphix (bubble or blister) for a group of potentially life threatening autoimmune mucocutaneous diseases characterized by epithelial blistering affecting cutaneous and/or mucosal surfaces.1 Pemphigus is an autoimmune disease in which a patient’s own circulating antibodies become altered so that they attack the points of adhesion of the epithelial cells, one to another, of the skin and mucous membranes. It most commonly develops in the fourth to sixth decades of life. We present an 18 year old patient with pemphigus vulgaris. The etiology was unknown.
2021
Pemphigus Vulgaris (PV) is a serious autoimmune disorder in the form of acute or chronic blisters on the mucocutaneous surface. The oral mucosa is the initial site of involvement in 50-60% of patients. Many known triggers have been associated with PV. This case report aims to describe a case of PV with an unusual clinical manifestation with multiple risk factors in elderly patient. A 78year-old woman came with a chief complaint of swelling on the lower lip for 3 months proceeded by oral ulcers on the lip vermillion. Extraoral examination showed diffuse swelling on the lower lip and a a cutaneous lesion on the right side of lower chin. Intraoral examination revealed ulcers and erosive lesion on the buccal mucosa. The medical history was rheumatoid arthritis treated with Dpenicillamine for 6 months. Working diagnosis of pemphigus vulgaris, acute pseudomembranous candidiasis, and angioedema were made. Several laboratory tests were performed. The anti-HSV-1 IgG test showed reactive. A t...
Pemphigus Vulgaris about a Case and Review of the Literature
Scholars Journal of Medical Case Reports
Introduction: Pemphigus vulgaris (PV) is a serious autoimmune disorder of the skin, which accounts for 80% of all pemphigus cases. Observation: This article describes the case of a 27-year-old woman with multiple skin wounds who was diagnosed with PV. The article also reviews the existing literature on the diagnosis and treatment of the disease. Conclusion: PV is a serious pathology with complex diagnosis and therapy, it requires multidisciplinary care associated with therapeutic education.
Effective Management of Pemphigus Vulgaris: A Case Report
Pak-Euro Journal of Medical and Life Sciences
Pemphigus vulgaris is a unique chronic condition of bullous autoimmune dermatosis whose development and diagnosis is mostly unidentifiable. It is classified as a specific hypersensitivity type II reaction that initiates the antibodies against the desmosomes, which are the maculae adherentes of the skin also known as the adhering spots in common term. These adhering spots keep the certain layers and compartments of the skin intact. When the desmosomes are invaded by the antibodies, the intact layers of the skin separate out and the clinical picture resembles a blister. With the passage of time the condition becomes worse and without treatment and monitoring the blister type lesions increase in size and surface area of the body similar to the condition of severe burn. The prime focus in the treatment of pemphigus vulgaris is to control the infirmity, prevent relapses, avoid adverse events and complications associated with the broad use of the steroids and immunosuppressive agents. Sys...