Lost in clocks: non‐canonical circadian oscillation discovered in Drosophila cells (original) (raw)

In this study, evidence is presented for non-canonical circadian oscillations in Drosophila S2 cells, which lack expression of key clock genes such as per and tim. Using quantitative multiomics approaches, researchers identified hundreds of rhythmic transcripts, proteins, and metabolites over a 57-hour time-course, suggesting that circadian oscillations can be driven by alternative molecular mechanisms independent of the traditional transcription-translation feedback loop (TTFL). The exploration of these non-TTFL mechanisms has significant implications for understanding circadian physiology in both cellular and organismal contexts.