CD 10 Expression Intensity in Various Grades and Stages of Urothelial Carcinoma of Urinary Bladder (original) (raw)
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CD10 expression in urothelial carcinoma of the bladder
Diagnostic Pathology, 2009
Background: CD10 antigen is a 100-kDa-cell surface zinc metalloendopeptidase and it is expressed in a variety of normal and neoplastic lymphoid and nonlymphoid tissues. The aim of this study was to evaluate CD10 expression in urothelial carcinoma of the urinary bladder and to determine the correlation between immunohistochemical (IHC) CD10 expression and histopathologic parameters including grade and stage. Methods: 371 cases of urothelial bladder carcinomas, all from transurethral resections, were included in this study. Hematoxylin-eosin (HE) stained sections from each case were reevaluated histopathologically according to WHO 2004 grading system. The TNM system was used for pathologic staging. Selected slides were also studied by IHC and a semiquantitative scoring for CD10 expression based on the percentage of positive cells was performed. Results: 157 cases (42.3%) showed immunostaining while 214 cases (57.7%) were negative for CD10. 1+ staining was seen in 65 CD10 positive cases (41.4%), and 2+ in 92 cases (58.6%). Overall CD10 expression as well as 2+ immunostaining was significantly correlated with high histologic grade. Overall CD10 expression was also significantly higher in invasive pT1 and pT2-3 tumors compared to noninvasive pTa tumors. pT1 and pT2-3 tumors were also significantly correlated with 2+ immunostaining. Conclusion: To date, only a few comparative IHC studies have assessed CD10 expression in urothelial carcinoma of the urinary bladder and this study represents the largest series. Our findings indicate that CD10 expression is strongly correlated with high tumor grade and stage in urothelial carcinoma of the bladder, and that CD10 may be associated with tumor progression in bladder cancer pathogenesis.
2010
CD10 is a cell surface metalloprotease that inactivates various bioactive neuropeptides. CD10 has been suggested as a useful prognostic marker for urothelial carcinoma, but there are only a few studies of CD10 in urothelial tumors and they have shown varying results. The aims of this study were to investigate the expression of CD10 in urothelial bladder carcinomas and to clarify its association with pathologic parameters. Materials and methods: A total of 50 urothelial bladder carcinomas were selected from archival material. All cases were reevaluated histopathologically and graded according to the WHO/ISUP 1998 classification. The TNM system was used for their pathological staging. CD 10 immunohistochemical staining was performed on one representative tissue block for each case. Results: 35 of the 50 (70%) tumors showed positive CD10 immunostaining. We found a statistically significant difference in terms of CD10 extent between low grade and high grade tumors. No association was de...
IP innovative publication pvt. ltd, 2019
Introduction: Urinary bladder cancer is common malignancy of the genitourinary tract in both males and females.CD10 is cell surface zinc dependent metalloprotease which may play a crucial role in tumor progression, invasion and metastasis. The present study was done to analyze staining pattern and intensity of CD10 and its association with grade, stage and prognosis of urothelial carcinoma. Materials and Methods: The prospective study included 51 cases of urothelial carcinoma over a period of one year which were followed up for three years. The staining pattern and intensity of CD10 immunostaining was correlated with histopathological grade, stage and survival of these patients. Results: The maximum number of urothelial carcinoma cases (33.3%) were in the age group of 60-70 years with mean age of 60.4 years. The staining pattern and intensity of CD10 showed statistical significant increase with increase of histopathological grade, stage of tumor and with decrease of survival of patients (p<0.05). Conclusion: The study concludes that there is significant association between staining intensity and score of CD10 immuno-expression with histopathological grade, stage and the survival in patients of urothelial carcinoma.The staining intensity and pattern of CD10 immuno-expression may be helpful in determination of prognosis of urothelial carcinoma cases. In addition, it is suggested that further larger studies with extended follow ups may be done to evaluate the exact role of CD10 in prognosis of urothelial carcinoma. Keywords: Urothelial carcinoma, CD10, Histopathological grade, Stage, Survival, Prognosis.
Expression of CD10 as a prognostic and predictive factor in urothelial carcinomas
Trakia Journal of Science, 2015
The aim of the study is to compare the expression of CD10 in invasive and non-invasive urothelial carcinomas. Methods: Primary sites of 40 cases of urothelial carcinomas were studied on H&E stained sections from the original biopsy paraffin block, out of them, 20-with and another 20without smooth muscle invasion. For CD 10 expression routine immunohistochemical procedure was applied, using DAKO FLEX monoclonal mouse antihuman clon 56C6. Results: Two groups-invasive and non-invasive urothelial cancers were compared in regard to CD10 expression. The results definitely reveal that most of the cells in all invasive cancers express CD10, while in non-invasive cancers CD10 expresion was absent. Conclusion: The results provide convinsing evidense for CD10 role in urothelial cancer invasiveness in underlying smooth muscle.