Dexamethasone influence on morphine-induced analgesia in inbred DBA/2J and C57BL/6 mice: A genetic study (original) (raw)
1992, Pharmacological Research
AI-generated Abstract
This research investigates the genetic differences in the interaction between dexamethasone (DEX) and morphine-induced analgesia in inbred DBA/2J and C57BL/6J mice. Previous findings indicated a greater degree of morphine analgesia in DBA mice compared to C57 mice. The study employed the hot plate test to evaluate the effects of DEX on morphine analgesia, revealing that while DEX reduced morphine analgesia in C57 mice, it did not affect DBA mice. These results suggest that genetic factors may influence the modulation of morphine analgesia by DEX, providing insights into pharmacogenetic interactions.
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