Persistent accumulation of 4-hydroxynonenal-protein adducts in gastric mucosa after Helicobacter pylori eradication (original) (raw)
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Recent research suggests that oxidative stress plays an important role in the development of gastroduodenal diseases associated with Helicobacter pylori. We investigated the variation of oxidative stress parameters following administration of antiulcer therapy in 79 patients with duodenal ulcer and chronic gastritis respectively, infected with Helicobacter pylori. Serum and tissue oxidative stress parameters were significantly modified in the period between diagnosis and healing of lesions. The results obtained indicated an increased production of oxygen reactive species at both serum and gastric tissue levels in the patients diagnosed with gastro-duodenal peptic disease. The production was directly correlated with the severity of the injury. In parallel a deficit of the physiological production of endogenous antioxidants was found, also correlated with the severity of the injuries. Antiulcer treatment led to the improvement of the antioxidant status, healing of lesions and eradicat...
Changes of oxidant and antioxidant status in humans due to H.Pylori infection
Nutrition Research, 1998
Helicobacter pylori (H. pylori) infection has been found to generate many oxygen-centered free radicals which are capable of producing lipid peroxidation. Lipid peroxidation, on the other hand, induces deficiency of many important antioxidative micronutrients. Lipid peroxidations, in terms of TBARS (thiobarbituric acid reactions substances) were measured in a cohort of 10 adult male H. pylori infected human subjects before and after eradication of this bacterium by a triple therapy regimen using omeprazole (20 mg), amoxicillin (1g) and metronidazole (400 mg) twice a day for two weeks. Presence and absence of H. pylori were ascertained by the 13C urea breath test (UBT). Total radical antioxidant parameters (TRAP) reflecting the antioxidative protection were also measured. The TBARS (μmol/l) were reduced from 2.99 ± 0.61 to 1.16 ± 0.19 with concomitant increase of TRAP values (mmol/l) from 1.1 + 0.4 to 1.9 + 0.4. after eradication of H. pylori. These significant (P<0.001) changes of oxidant, i.e. lipid peroxidation, and antioxidant (TRAP) status suggest prevalence of oxidative stress in humans due to H. pylori infection. Since oxidative stress is implicated in many life threatening diseases, results of this preliminary study strongly suggest prospective investigations of the association of H. pylori with human health disorders.
IASET, 2013
Objective: Gastric ulcer, also known as peptic ulcer, is a localized area of erosion in the stomach lining, resultin abdominal pain, possible bleeding, and other gastrointestinal symptoms. The most common cause of gastric ulcer is a stomach infection associated with the Helicobacter pylori (H pylori) bacteria. The spread of H pylori among humans is not completely understood; it may spread through contaminated food and water. Antioxidants are molecules which can safely interact with free radicals and terminate the chain reaction before vital molecules are damaged. The aim of the current study is to investigate the oxidative stress in patients with H. pylori and compare to control group.