A Review of Wound: Current Aspects and Novel Management (original) (raw)
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Exploring the use of herbal drugs and advanced supporting techniques for wound healing
Bulletin of the National Research Centre, 2022
Background A wound may define as an interruption within the continuity of the epithelial lining of the skin or mucosa that occurs as a result of physical or thermal damage. Wound healing is an intricate process that is highly synchronized censorious in the management of the protective means of the skin. There are a variety of systemic and local factors that influence wound healing, including oxygenation, inflammation, age, stress, diabetes, nutrition, and nicotine. Hemostasis, inflammation, proliferation or granulation, remodeling or maturation are the principle phases of wound healing. Main body of the abstract The authors of the current review attempt to convey that the usage of herbal drugs has extreme importance in the current era. The authors reviewed a total of 38 herbal plants with their mechanism of wound healing and the chemical constituents responsible for it. Hyperbaric oxygen therapy, negative pressure therapy, platelet-rich plasma therapy, stem cell therapy, and biosurg...
2013
In this case blood escapes the body and bleeding is clearly visible. It is further classified as: Incised wound, laceration or tear wound, Abrasions or superficial wounds, Puncture wounds, Penetration wounds and gunshot wounds. 7 Closed wounds In closed wounds blood escapes the circulatory system but remains in the body. It includes Contusion or bruises, heamatomas or blood tumor, Crush injury etc. Acute wounds Acute wound is a tissue injury that normally precedes through an orderly and timely reparative process that result in sustained restoration of anatomic and functional integrity. Acute wounds are usually caused by cuts or surgical incisions and complete the wound healing process within the expected time frame. 8 Chronic wounds Chronic wounds are wounds that have failed to progress through the normal stages of healing and therefore enter a state of pathologic inflammation chronic wounds either require a prolonged time to heal or recur frequently. Local infection, hypoxia, trauma, foreign bodies and systemic problems such as diabetes mellitus, malnutrition, immunodeficiency or medications are the most frequent causes of chronic wounds. 9 WOUND HEALING MECHANISM Wound healing, as a normal biological process in the human body, is achieved through four precisely and highly programmed phases: hemostasis, inflammation, proliferation, and remodeling. For a wound to heal successfully, all four phases must occur in the proper sequence and time frame. Many factors can interfere with ABSTRACT A wound may be defined as a break in the epithelial integrity of the skin or may also be defined as a loss or contravention of cellular and anatomic or functional permanence of living tissue. Wound healing is the process of repair that follows injury to the skin and proper healing of wounds is crucial for the re-establishment of disrupted anatomical continuity and disturbed functional status of the skin. The phyto-medicines for wound healing are not only economical and inexpensive but are also supposedly safe as hyper sensitive reactions are rarely encountered with the use of these agents. Many plants have proved to possess momentous healing properties in poles apart from type of wounds. Nature has best owed on us a very rich botanical wealth and a large number of diverse types of plants grow in different parts of the country. This review examine about wound healing prospective of plants, its family, part used, extract used, model used and references which are supportive for researchers for expansion of novel wound healing formulation.
Wound Healing: Role of Traditional Herbal Medicine Treatment
International Journal of Innovation Scientific Research and Review, 2022
This review paper highlights about wound healing, a vital physiological process of tissue repair or remodelling, which still remains a challenge in the Indian healthcare system. Different wound dressings containing antibiotics and antibacterial agents, nanoparticle based wound dressings prevent bacterial infection and bio film formation in the wound bed. However, the use of antibiotics, allopathic drugs and antibacterial nanoparticles in wound healing has some limitations since most of these antibacterial agents have side effects such as cytotoxicity. Furthermore, there is no efficient evidence-based therapy available for specific chronic wounds. Another problem is wound healing and wound management is very expensive health care, which poor people cannot afford to bear expenditure. There are a variety of herbal plants that have wound healing properties. Plant-based constituents have been extensively used for the treatment and management of different types of wounds. Folklore cultures employ a significant number of plants to treat cuts, wounds, and burns. Therefore, the use of Complementary and Alternative herbal Medicines (CAMs) is a promising approach to improvising clinical and medical challenges faced by non-healing chronic wounds. In addition to this, the use of natural plant derived substances are considered safe compared to synthetic molecules and can be much cheaper than conventional therapies.
A review of herbal medicines in wound healing
International journal of dermatology, 2015
Herbs have been integral to both traditional and non-traditional forms of medicine dating back at least 5000 years. The enduring popularity of herbal medicines may be explained by the perception that herbs cause minimal unwanted side effects. More recently, scientists increasingly rely on modern scientific methods and evidence-based medicine to prove efficacy of herbal medicines and focus on better understanding of mechanisms of their action. However, information concerning quantitative human health benefits of herbal medicines is still rare or dispersed, limiting their proper valuation. Preparations from traditional medicinal plants are often used for wound healing purposes covering a broad area of different skin-related diseases. Herbal medicines in wound management involve disinfection, debridement, and provision of a suitable environment for aiding the natural course of healing. Here we report on 22 plants used as wound healing agents in traditional medicine around the world. Th...
Current Aspects of Wound Healing Agents From Medicinal Plants: A Review
Wound is defined as the disruption of the cellular and anatomic continuity of a tissue. Wound may be produced by physical, chemical, thermal, microbial or immunological insult to the tissues. The process of wound healing consists of integrated cellular and biochemical events leading to re-establishment of structural and functional integrity with regain of strength in injured tissues. This review discuss about Wound healing potential of plants, which are helpful for researcher to development new Wound healing formulations for human use.
Significant Natural Wound Healing Agents: Herbs and Single Bioactive Principles
Yüzüncü Yıl Üniversitesi Tarım Bilimleri Dergisi
Wounds are caused by skin injuries that damage the soft tissue. Wound healing is a dynamic process that involves a series of interconnected cellular and molecular processes that result in the restoration of anatomic continuity and function. Herbal therapy has been gaining popularity recently because of plants' usefulness in treating ailments with hardly any negative effects. Over the years, a variety of plant items have been developed and utilized to heal wounds. Throughvarious mechanisms, herbal extracts aid in blood clotting, infection prevention, and wound healing. This review provides a comprehensive look at herbal therapy's potential for hastening wound healing, as well as its antioxidant, anti-inflammatory, and anti-microbial properties that can be manifest in the treatment of injuries, as well as a first attempt at developing new wound-healing formulations with high potency for human use. Furthermore, we have highlighted medicinal plants as natural antioxidant resourc...
Wound Healing Activity of Some Medicinal Plants: A Review
2014
Wound is defined as the disruption of the cellular and anatomic continuity of a tissue. Wound may be produced by physical, chemical, thermal, microbial or immunological insult to the tissues. The process of wound healing consists of integrated cellular and biochemical events leading to re-establishment of structural and functional integrity with regain of strength in injured tissues. Naturally, the investigative curiosity to promote healing continues since ages. Plants and their extracts have immense potential for the management and treatment of wounds. The phyto-medicines for wound healing are not only cheap and affordable but are also purportedly safe as hyper sensitive reactions are rarely encountered with the use of these agents. These natural agents induce healing and regeneration of the lost tissue by multiple mechanisms. However, there is a need for scientific validation, standardization and safety evaluation of plants of the traditional medicine before these could be recommended for healing of the wounds.
Plant-Derived Medicines with Potential Use in Wound Treatment
Herbal Medicine
The skin is among the largest and one of the most important organs in the human body. It represents the first line of defence of the body; provides protection from mechanical impacts of the environment, limits the influence of variations in the temperature, prevents entrance of chemicals and microorganisms and restricts radiation effect. Skin damage affects all skin functions; therefore, wounds can compromise patient's well-being, self-image, working capacity and independence. Due to all mentioned, a good wound management is necessary not only for the individual but also for the community. Herbal medicines have been used to accelerate wound healing since ancient times. Recently, scientists have been able to employ scientific methods to prove efficacy of many of these herbs and to get a better understanding of mechanisms of their actions. The popularity of herbal medicines may be explained by the perception that herbs cause minimal adverse effects. Preparations from traditional medicinal plants in wound management involve disinfection, debridement and the provision of suitable environment for natural healing process. In this chapter, the field of wound healing is briefly introduced. Further, the crucial information regarding plants, which are effectively used as wound healing agents in traditional medicine are gathered.
Chapter-7 Wound Healing Potential of Medicinal Plants as Natural Products
The wound healing process is made up of interconnected cellular and molecular stages that work together to heal the wound. Wound healing can be defined as a succession of processes completed by the body, with each stage increasing the likelihood of microbial infection. Improved wound healing can be attained by shortening the healing time or reducing the number of inappropriate events. To aid wound healing, the medicines were administered locally or systemically. Antibiotics, antiseptics, desloughing agents, extracts, and other compounds have been used to promote wound healing. Some synthetic medications are restricted due to their harmful effects. Plants or plant derived mixtures are required to explore, identify, and formulate for wound healing treatment and management. Because of the fewer side effects and management of wounds, there has been an increase in interest in using medicinal herbs in wound healing throughout the years. In research, medicinal herbs were found to help diabetic, infected, and open wounds heal faster. Medicinal plants have been shown to aid in wound healing through a variety of processes. This chapter will go through some therapeutic plants as well as reported active ingredients with pharmacological efficacy in formulations.
Novel therapeutics and treatment regimen in wound healing
Novel Therapeutics and treatment regimen in Wound Healing, 2021
Since antiquity, wounds have inflicted enormous pain and suffering to mankind. Amelioration of this pain, faster healing was a daunting task for us from ancient times. The process of wound healing is complex and tightly regulated which mainly affect certain tissues of the bodyprimarily including the skin. It is of paramount importance as it concerns reinstating the integrity of the skin tissues. The cascade of recovery of the wounds may be affected due to a plethora of disease processes, which is further known to induce considerable distress and perturbation to the patients. Medical science has been keen on understanding the mechanism of wound healing and has used many medicaments to help reduce the duration of relapse or recovery. The treatment methods span from the usage of many phytoconstituents to the modern regimen of using novel formulations. The aim of this article is therefore to review the recent biotechnological interventions along with novel treatment regimen that have been devised over the years and pose great potential for the effective treatment of a multitude of wounds.