Contents of 1,4-Benzoxazin-3-ones and 2-Benzoxazolinone from Stenandrium dulce (Nees) (original) (raw)
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Distribution of steroid like compounds in plant flora
Pharmacognosy Magazine, 2006
Medicinal herbs constitute an effective source of traditional (Ayurvedic, Unani and Homeopathy) and modern medicine. The plant is a biosynthetic laboratory, not only for chemical compounds, but also a multitude of compounds like glycosides, alkaloids etc. These exert physiological and therapeutic effect. The compounds that are responsible for medicinal property of the drug are usually secondary metabolites. Alkaloids, glycosides, neutral principles, resins, oleoresins, sesquiterpene lactones are some of the common active constituents of medicinal herbs. The article reviews distribution of steroid like compounds and their pharmacological importance.
O -Prenylated Acridone Alkaloids from the Stems of Balsamocitrus paniculata (Rutaceae)
Planta Medica, 2011
Introduction ! Balsamocitrus paniculata (Schum.) Swingle (Rutaceae), synonym Afraegle paniculata (Schum. and Thonn.) Engl. and Citrus paniculata (Schum. and Thonn.), is an African medicinal plant called Nigerian powderflask used in traditional medicine for the treatment of malaria, hypertension, infertility, and influenza [1-3]. Previous phytochemical investigations revealed coumarins, quinoline alkaloids, and free aliphatic acids including a triacid triglyceride and steroids [4], some of these compounds exhibiting potent antibacterial, fungicidal, and algicidal properties . Widespread traditional medicinal use and significant biological activities of compounds investigated so far justified continued investigation of B. paniculata. This paper reports the isolation and structure elucidation of two new O-prenylated acridone alkaloids (1-2), together with antimicrobial, oxidative burst inhibition and cytotoxic activities of isolated compounds.
GC-MS and HPLC-ESI-MS-MS Characterization of Sanchezia oblonga (Acanthaceae) Extracts
Journal of Food Research
The genus Sanchezia (Acanthaceae) comprises neotropical herbs and shrubs with showy flowers. Sanchezia oblonga (syn. S. nobilis) is a shrub of the rainforests of central and south America. The ethanolic extracts of leaves and stems from S. oblonga were analyzed by GC-EI-MS and RPHPLC-DAD-ESI-MS/MS. Fatty acids (free and esterified) and phytosterols were detected by the former method. Benzyl alcohol glycosides (21 and 25), sinapic acid glycoside esters (29 and 31), ethyl rosmarinate (24), sinapic acid-O-glucoside (28), dihydrosinapic acid-O-glucoside (26), catechin-O-arabinoside (36), in addition to flavonols glycosides (23, 32, 33 and 35) and rosmarinic acid-3’-O-glucoside (34) were detected by RPHPLC-DAD-ESI-MS/MS. Three new compounds, detected only in leaves, were tentatively identified as phenylpropane glyceride derivatives 1-O-coumaroyl-2-hydroxy propanal (20) and 1-O-coumaroyl-2-O-glycosyl propanal (22, 30). Compounds 20, 22 and 30 from S. oblonga are similar with phenylpropane...
Steroidal Saponins from Fresh Stems of Dracaena angustifolia
Journal of Natural Products, 2010
Six new steroidal saponins (1-6), angudracanosides A-F, were isolated from fresh stems of Dracaena angustifolia (Agavaceae), together with eight known compounds. The structures of compounds 1-6 were determined by detailed spectroscopic analyses and chemical methods. Antifungal testing of all compounds showed that 6 and 7 were active against Cryptococcus neoformans with IC 50 s of 9.5 and 20.0 μg/mL, respectively.
Secondary Metabolites from the Roots of Astragalus zahlbruckneri
Journal of Natural Products, 2001
Four new phenolic glycosides, -apiofuranosyl-(1f2)--glucopyranosides (1-4), along with the cycloartane triterpenes 20(R),25-epoxy-3 ,6R,16 ,24R-tetrahydroxycycloartane (5) and 20(R),24(S)-epoxy-3 ,6R,25trihydroxycycloartan-16-one (6) were isolated from roots of Astragalus zahlbruckneri. The structure elucidation of all compounds was based on their 1 H and 13 C NMR spectral data including 1D-TOCSY, DQF-COSY, HSQC, and HMBC experiments.
Chemical indexes calculated for 8,11,13-trien-abietane diterpenoids isolated from Swartzia species
Eclética Química, 2010
The disparity found in the molecular structures of compounds isolated from nine plants of the Swartzia genus indicates that the Swartzia species that furnished cassane diterpenoids and triterpenoidal saponins are more recent, since these metabolites have adopted the mevalonic acid route of formation, abandoning the shikimic acid/acetate route that produces the isoflavonoids found in the remaining species. Chemical indexes calculated from the molecular structure diversities of sixteen 8,11,13-trien-abietane diterpenoids isolated from Swartzia langsdorffii and S. arborescens indicate that S. arborescens is more recent than S. langsdorffii. The results suggest a more evolved position in Swartzia species of the section Possira.
Sift Desk Journals, 2018
High efficiency and less solvent consumption are the essential requirements of high-speed counter current chromatography (HSCCC), especially for the preparation and purification of natural products. In this manuscript, an efficient HSCCC strategy with preparative high performance liquid chromatography (preparative-HPLC) was successfully developed to rapidly separate and purify six lupane-type triterpenoids (including acankoreoside C (1), acangraciliside S (2), acankoreoside B (3), acankoreoside D (4), acantrifoside A (5) and acankoreoside A (6)) from leaves of the Acanthopanax gracilistylus. The effective separation was achieved using ethyl acetate–n-butanol–methanol–water (3:0.3:0.8:4, v/v/v/v) as the two-phase solvent system, in which the mobile phase was eluted at an optimized flow rate of 2.0 mL/min and a revolution speed of 900 rpm. HSCCC preparation was performed on 400 mg of crude sample yielding 5.3 mg of compound 3, 6.4 mg of compound 4, 10.6 mg of compound 5, 35.8 mg of compound 6 with purities of 95.6%, 96.3%, 96.1%, 97.2%, respectively, 17.2 mg of a mixture of compounds 1 and 2, which was further separated by preparative-HPLC yielding 5.9 mg of compound 1, and 4.5 mg of compound 2 with purities of 96.8% and 94.6%, respectively, as determined by HPLC at 210 nm. Their chemical structures were identified by nuclear magnetic resonance (NMR) technology. All compounds were evaluated for their anti-inflammatory activity with lipopolysaccharide (LPS)-induced RAW264.7 cell. The compounds 3 and 4 showed weakly inhibitory effect of nitric oxide (NO) production with low cytotoxicity. Keywords Acanthopanax gracilistylus, High-speed counter current chromatography (HSCCC), Preparative-HPLC, Nitric oxide (NO), Cytotoxicity