A subset of two adherence systems, acute pro-inflammatory pap genes and invasion coding dra, fim, or sfa, increases the risk of Escherichia coli translocation to the bloodstream (original) (raw)

2013, European Journal of Clinical Microbiology & Infectious Diseases

An analysis of the phylogenetic distribution and virulence genes of Escherichia coli isolates which predispose this bacteria to translocate from the urinary tract to the bloodstream is presented. One-dimensional analysis indicated that the occurrence of P fimbriae and α-hemolysin coding genes is more frequent among the E. coli which cause bacteremia. However, a two-dimensional analysis revealed that a combination of genes coding two adherence factors, namely, P + Dr, P + S, S + Dr, S + fim, and hemolysin + one adherence factor, were associated with bacteremia and, therefore, with the risk of translocation to the vascular system. The frequent and previously unrecognized coexistence of pro-inflammatory P fimbriae with the invasion promoting Dr adhesin in the same E. coli isolate may represent high-risk and potentially lethal pathogens. Escherichia coli, the predominant facultative organism of the intestinal flora, can cause severe extra-intestinal infections, including infection of the kidney (pyelonephritis) or bloodstream (bacteremia). When it escapes from its usual habitat, E. coli can colonize the genital tract and, as a subsequent step, ascend to the bladder and kidneys. Ascending urinary tract infection (UTI) is well explained by tissue receptor-E. coli adhesins interactions. Several E. coli virulence factors, including toxins, are implicated in renal inflammatory injury and