Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse (original) (raw)

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Nature, 1999

Abstract

Amyloid-peptide (A ) seems to have a central role in the neuropathology of Alzheimer's disease (AD) 1 . Familial forms of the disease have been linked to mutations in the amyloid precursor protein (APP) and the presenilin genes 2 , 3 . Disease-linked mutations in these genes ...

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