IgA-mediated anti-glomerular basement membrane disease. A case report (original) (raw)
Anti-glomerular basement membrane (anti-GBM) disease is typically mediated by IgG autoantibodies, presenting as rapidly progressive glomerulonephritis. This case report details a 65-year-old man diagnosed with IgA-mediated anti-GBM disease, confirmed by renal biopsy showing linear IgA staining along glomerular capillary loops. Despite standard treatment involving plasmapheresis and steroids, the patient's prognosis remained poor, leading to end-stage renal disease (ESRD). The findings highlight the need for specific diagnostic markers and treatment strategies for IgA-mediated anti-GBM disease, distinguishing it from its IgG counterpart.