Atypical Connectivity Lateralization Associated With Autism Presents Within The First Year Of Life (original) (raw)

2021

Abstract

Autism spectrum disorder (ASD) is putatively characterized by abnormal connectivity and lateralization of large-scale functional networks in school-age children. However, previous studies have not directly investigated if differences in cerebral lateralization between ASD and typically-developing peers are present during pre-symptomatic stages of the disorder in infancy, leaving the time of onset of these differences unknown. We used a voxel-based method—which examines each voxel’s connectivity to every other voxel in each hemisphere—to study connectivity lateralization in school-age children with ASD and infants later meeting Autism Diagnostic Observation Schedule (ADOS) criteria for ASD. Analyses were performed in two unique samples: 1) 733 school-age children with ASD and typically developing peers from ABIDE database, and 2) 71 infants at high risk (HR) and normal risk (NR) for ASD with data collected longitudinally 1-month and 9-months from the NDAR database. Comparing school-a...

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