Surfactant Protein A Serum Level in Cement Worker (original) (raw)

The Surfactant Protein D (SP-D) Serum Levels in Limestone Mining Worker

Jurnal Respirologi Indonesia

Background: Limestone is sedimentation rocks consist of minerals calcite and aragonite, often contains silica, and fossils, commonly used in building materials. Limestone mining workers are at high risk to pneumoconiosis. Surfactant protein D(SP-D) is part of collectin family, and served as innate immune system of pathogen recognition receptor (PRR). SP-D level were usually increased in fibrotic lung disease. In this study, we sought the serum level of SP-D as marker for early pneumoconiosis in limestone worker in Indonesia.Method: This study was cross-sectional observational study. Participant of the study were 65 limestone workers, willing to participate in this study by signing informed consent, were questionnaire, and blood sample were collected to measure SP-D level by ELISA.Results: This study found that characteristic subjects dominated by male with the median of age was 42 years old and last education mostly elementary school. Majority duration of working <6 years and tim...

Proportion of Pneumoconiosis in Limestone Mining Workers In Citatah Village, West Bandung District

Respiratory Science

Background: Silica, asbestos and coal dust are associated with pneumoconiosis in mining workers. The International Labor Organization (ILO) reports that 30-50% of workers in developing countries are diagnosed with pneumoconiosis. This study aims to identify pneumoconiosis in limestone mining workers in Indonesia. Method: This cross-sectional study involved 73 subjects of limestone mining workers in Citatah Village, West Bandung Regency, Indonesia. Two conclusions were similar from three AIR-Pneumo certified photo readers by blind reading and using the ILO guidelines. Result: Pneumoconiosis was found in 11/73 (15.1%). The median age of the pneumoconiosis group was older than the non-pneumoconiosis group (51 [33-63] vs. 37.5 [18-85] age in years, p = 0.013). All subjects in the pneukoniosis group worked> 6 years (p = 0.001). The highest dust concentration was in the pneumoconiosis group compared to the non-pneumoconisosis group (61.41 ± 103.98 vs. 14.92 ± 55.17 mg / m3, p = 0.030)....

A simple diagnostic model for ruling out pneumoconiosis among construction workers

Occupational and Environmental Medicine, 2007

Background: Construction workers exposed to silica-containing dust are at risk of developing silicosis even at low exposure levels. Health surveillance among these workers is commonly advised but the exact diagnostic work-up is not specified and therefore may result in unnecessary chest x ray investigations. Aim: To develop a simple diagnostic model to estimate the probability of an individual worker having pneumoconiosis from questionnaire and spirometry results, in order to accurately rule out workers without pneumoconiosis. Methods: The study was performed using cross-sectional data of 1291 Dutch natural stone and construction workers with potentially high quartz dust exposure. A multivariable logistic regression model was developed using chest x ray with ILO profusion category >1/1 as the reference standard. The model's calibration was evaluated with the Hosmer-Lemeshow test; the discriminative ability was determined by calculating the area under the receiver operating characteristic curve (ROC area). Internal validity of the final model was assessed by a bootstrapping procedure. For clinical application, the diagnostic model was transformed into an easy-touse score chart. Results: Age 40 years or older, current smoker, high-exposure job, working 15 years or longer in the construction industry, ''feeling unhealthy'' and FEV 1 were independent predictors in the diagnostic model. The model showed good calibration (a non-significant Hosmer-Lemeshow test) and discriminative ability (ROC area 0.81, 95% CI 0.74 to 0.85). Internal validity was reasonable; the optimism corrected ROC area was 0.76. By using a cut-off point with a high negative predictive value the occupational physician can efficiently detect a large proportion of workers with a low probability of having pneumoconiosis and exclude them from unnecessary x ray investigations.

Pneumoconiosis among workers in a Vietnamese refractory brick facility

American Journal of Industrial Medicine, 2002

Background Vietnam is a rapidly industrializing country with increasing needs for building materials, including refractory bricks. The manufacture of refractory bricks results in high levels of free silica, a recognized occupational hazard. Methods A cross-sectional survey was conducted among 158 employees using a respiratory symptom questionnaire and ILO classification of radiographs for pneumoconiosis. Results The prevalence of radiographic silicosis (ILO category 1/0 and greater) was 10% in all workers with evidence of a dose-response gradient. Pneumoconiosis prevalence increased from 0% in workers employed < 10 years at the plant to 18% for workers employed > 20 years (trend test P ¼ 0.01 for each year increment after adjusting for gender and tobacco use). Conclusions Workers in this plant demonstrate a consistent pattern of radiographic evidence of pneumoconiosis, which appears to be related to duration of work. Future studies should assess exposure control measures that are appropriate to countries undergoing rapid industrialization such as Vietnam.

HEALTH RISK IN WORKERS EXPOSED TO WET CEMENT

Construction industry is one of the booming industries in the world. Workers engaged in this field are exposed to various hazardous substances. Portland cement is the common type of cement in usual usage and it consists of many toxic constituents. Exposure to these constituents may lead to various health effects and chronic complications. The study comprises 508 cases which include labors in construction field. The study group is categorized into 3 (less than 10 years of exposure, 10-20 years and more than 20 years). Sixty percent individuals belonged to the category of masons, 21 % helpers, 12% concrete mixers and 7% tile workers. Cutaneous problems have been reported by 90 % of masons. Helper group reported skin related problem as well as pulmonary ailments. Forty two percentages of workers were affected by skin rashes/ inflammations. In concrete mixers 72 % have skin burns and 23% have pulmonary function impairment. Seventy percentages of tile workers have cutaneous problems

Comparative Study of Changes in Inflammatory Markers on Hours of Exposure to Cement Dust

Asian Journal of Advanced Research and Reports

Background: There has been a growing concern about the health of people exposed to cement dust. Objective: This study was aimed at assessing the effect of cement dust on inflammatory markers on cement loaders with different duration of hourly exposure. Methods: This is a cross-sectional study design conducted in Port Harcourt, Nigeria with 100 male cement workers grouped into 3 groups based on the hourly duration of cement dust exposure. Group 1 (27 subjects) was exposed to 1-5 daily hours; Group 2 (62 subjects), was exposed to 6-10 daily hours, and Group C (11 subjects), was exposed to more than 10 daily hours. The ELISA analysis of C-Reactive protein (CRP), IL-1β, and IL-10 was performed. The data generated were analyzed for mean and standard deviation by ANOVA. Results: The CRP levels were 5.42 ± 4.72; 6.71 ± 4.96 and 9.04 ± 8.83 in groups 1, 2, and 3 respectively. The p-value was 0.1771 implying no significant difference. The IL-10 levels were 15.72 ± 12.58; 12.23 ± 10.12 and 11...

Occupational Cement Dust Exposure and Inflammatory Nemesis: Bangladesh Relevance

Journal of Inflammation , 2021

Background: Prolonged, repeated exposure to cement dust, depending on duration and sensitivity of cement dust-exposed workers, may cause deteriorating effects on the skin, eye, respiratory and hematological system. Toxic cement dust causes inflammatory damage to different body organs. White blood cells (WBCs) are considered cellular markers of ongoing tissue inflammation. Aim of the Study: Determining the influence of occupational cement dust exposure on WBCs with its differentials (inflammatory markers) in workers from the cement manufacturing plant. Methodology: Ninety-two seemingly healthy male subjects (46 workers of cement plant and 46 control subjects, who do not contact cement dust, residing in Dhaka) aged between 20 and 50 years participated in this cross-sectional study. This study took place in Dhaka Medical College, Bangladesh, between the years of 2017 and 2018. An automated hematoanalyser was used to assess both the total and differential count of WBC. Data were analyzed with multivariate regression analysis, independent samples t-test, and correlation test. Results: The total WBC count, differential count of lymphocyte, and eosinophil were significantly (p< 0.05) higher in cement dust-exposed recruits than in the control group. Additionally, multivariate regression analysis revealed that duration of cement dust exposure showed a significant association with total WBC count [odds ratio (OR)=4.42,95%, confidence level (CI) 1.56,12.47, p 0.005]. Furthermore, univariate analysis revealed that the control group (not exposed to cement dust) was less likely to have the total WBC count alteration (OR = 0.122, 95% CI =0.047 to 0.311) than the cement dust-exposed group. The total WBC count showed a significant positive correlation with exposure duration to this toxic dust. Conclusion: Cement dust exposure causes harmful inflammatory responses, as evidenced by increased total and differential WBC count. The period of contact with this toxic dust has an impact on WBC count.

An epidemiological study on effect of occupational exposure of cement

International Journal Of Community Medicine And Public Health, 2018

Background: Construction industry chiefly depends on the cement. The constituents in the cement have various health effects in the exposed group. The present study focused to realize the health effects of cement exposure and duration of exposure.Methods: The sample size was 831 male workers. The labourers included were construction workers (masons, helpers and concrete mixers) and cement loading and unloading workers. They were categorized in to five groups which were 5-9, 10-14, 15-19, 20-24 and 25+ years based on the duration of exposure to cement. Health hazards among these labourers were categorized in to lung function impairment symptoms, cutaneous symptoms and other symptoms.Results: High frequency of respiratory tract ailments (persistent cough 54%, breathlessness 47%) was observed among loading workers as they were handling cement dust. Burning was the most observed one in concrete mixer (70%), hair loss and change in hair colour was observed in 60% of all categories of work...

Assessment of Infectious and Inflammatory changes in sputum associated with cement dust

2014

Article History Background: sputum cytology is an important biomarker that can be used to assess infectious and inflammatory changes associated with different etiological factors. Therefore, the objective of this study was to assess the infectious and inflammatory changes associated with exposure to cement dust. Methodology: In this cross-sectional cases control study, 500 apparently healthy volunteers were selected. Of the 500 study subjects, 400 were exposed to cement dust (ascertained as cases) and 100 were non-exposed (ascertained as controls). Sputum specimen was collected and subsequently demonstrated using Papanicalauo method. Results: Inflammatory cells infiltrate associated with exposure to cement dust was found to be statistically significant (RR= 2.1214, 95% CI = 1.6142 to 2.7881, P < 0.0001). The risk of viral infection associated with exposure to cement dust was found to be (RR= 1.6250, 95% CI = 0.7078 to 3.7308, P = 0.2522). The risk associated with bacterial infect...

Effect of Cement Dust on Pulmonary Functions of Cement Workers

Men's health journal, 2020

Background: Among cement dust, quartz particles are the most harmful and cause pulmonary fibrosis, which is pathologically among the severe and malignant pneumoconioses. Therefore, by measuring the dust and examining the status of lung functions among workers, we can assess the effects of inhaling cement dust. We aimed to assess the effect of cement dust on pulmonary functions among cement workers during 1999-2000 in Khash, Sistan and Baluchestan Province, Iran. Material and Methods: The total and inhalation dust of the working environment of different units in this industry was measured by individual sampling pump and silicon by weight method and after correcting the volumes, mg/m3 of dust was calculated. Results: The total dust in different environments was 6.8-95 mg/m3 and the inhaled dust was 2.5-23 mg/m3. Due to the percentage of free silica associated with dust, these values are several times the standard values in the workplace. The mean values of respiratory functions (FEV...