Immunoexpression and correlation of Cytotoxic T lymphocytes in Oral Squamous Cell Carcinoma with lymph node status: A Retrospective study (original) (raw)
2018, International journal of scientific research
Background & Objectives: In OSCC, the presence of regional lymph node metastasis at presentation is the most significant adverse prognostic factor and a major determinant of poor survival. Tumor-infiltrating lymphocytes (TILs) often infiltrate solid malignant tumours and extensive lymphocyte infiltration has been related with a more favourable prognosis in patients with various cancers. OSCC often contain large mononuclear cell infiltrates, comprised mainly of T cells, which could reflect an in situ immune reaction against the malignant OSCC cells. The aim of this retrospective study was to evaluate the expression of Cytotoxic T lymphocyte in OSCC using immunohistochemical marker CD8+(CTLs) and correlate these findings with the status of lymphnode. Methods: The study was conducted on tissue sections obtained from histopathologically diagnosed cases of OSCC (n=30) retrieved from the archives of Department of Oral and Maxillofacial Pathology. The sample consisted of cases showing lymph node metastasis (n=15) and those without pathologic lymph node involvement (n=15). The sections were evaluated by using immunohistochemical staining technique with marker CD8 for Cytotoxic T lymphocytes. The mean immunoexpression of Cytotoxic T lymphocyte was evaluated and correlated with lymphnode status. Results: A statistically significant increase in the count of CTLs (CD8+) was observed in lymph node negative pN(-) as compared to lymph node positive cases pN(+) of OSCC. Interpretation & Conclusion: CTLs (CD8+) are involved in modulating the immune response and can contribute to the dissemination or control of metastatic neoplastic cells. It can be considered that T-cell mediated adaptive immunity plays a key role in anti-tumour immunity.
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