Aluminium and Alzheimer’s Disease: A Suspicious Link (original) (raw)

Aluminium (Al) has long been implicated in the etiology of the neurodegenerative diseases like Alzheimer's disease (AD). Although abundant studies substantiated its potential role in inducing neurotoxic effects, yet this subject has been a controversy of profound importance. This article summarizes the various ways in which Al induces oxidative stress, eventually leading to cell death. It also gives a brief account of manifold epidemiological studies that relate the abundant occurrence of Al in soil and water and the prevalence of AD. Al carriers, their role in AD, Al in neurofibrillary tangles, biochemical reactions altered by Al influx in mitochondria have been briefly discussed.