An unusual case of isolated, serial metastases of gallbladder carcinoma involving the chest wall, axilla, breast and lung parenchyma (original) (raw)
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2015
In the English literature, only 9 cases of ade-nocarcinoma of the gallbladder with cutaneous metastasis have been reported so far. One case of multiple cutaneous metastases along with deposits in the breast tissue has been report-ed. We present a case of incidental metastatic gallbladder carcinoma with no intra-abdominal disease presenting as a series of four isolated cutaneous right chest wall, axillary nodal, breast, and pulmonary metastases following resection and adjuvant chemoradiation for her primary tumor. In spite of the metastatic dis-ease coupled with the aggressive nature of the cancer, this patient reported that her energy level had returned to baseline with a good appetite and a stable weight indicating a good performance status and now is alive at 25 months since diagnosis. Her serially-present-ed, oligometa static diseases were well-con-trolled by concurrent chemoradiotherapy and stereotactic radiation therapy. We report this case study because of its rarity and for t...
Metastasis to Breast From Carcinoma Gallbladder: A Case Report and Review of Literature
Cureus
Gallbladder cancer (GBC) is the commonest malignancy among biliary tract cancers. Locoregional spread in GBC is more common than distant metastasis. The liver and abdominal lymph nodes is the most common site of distant metastasis. Breast metastasis is a rare site of dissemination. GBC is an aggressive tumor and carries a poor prognosis, with a five-year survival rate of less than 10%. Metastasis to the breast from a gallbladder is significantly less and accounts for very few cases. Here, we are reporting a rare case of carcinoma gallbladder metastasis to the breast who survived for 38 months from the diagnosis of GBC and around 25 months after breast metastasis.
Imaging Diagnosis of Metastases to Breast: A Rare Presentation of Carcinoma Gallbladder
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2017
A 45-year-old post-menopausal female, resident of North India, presented with an ulcero-proliferative mass in the epigastric region accompanied by multiple masses in both breasts for the past one year [Table/Fig-1]. On examination, the epigastric ulcero-proliferative mass was seen to extend into the midline chest wall and the right breast. Additionally, multiple nodules of firm consistency were palpable in the skin and subcutaneous tissue of both breasts. On persistent enquiry, the patient submitted a history of laparoscopic cholecystectomy for cholelithiasis, performed two years earlier at some other hospital. However, the previous relevant medical records were not available. The clinical team suspected occult primary malignancy with metastasis. A prompt routine laboratory and radiological evaluation was resquisitioned which included ultrasound of both breasts, CT study of thorax and abdomen. Laboratory parameters were found to be within normal limits. Ultrasound of both breasts revealed multiple well-circumscribed hypoechoic
La Clinica terapeutica
Gallbladder metastasis of breast cancer are rare, particularly linked to lobular histotype and synchronous just in 1/4 cases. A review of the literature has been performed aimed to evidence the patterns of gallbladder metastases of breast cancer finding 15 cases to whom we added a 48 years old post-menopausal woman. 3 weeks after surgery for mixed ductal-lobular breast carcinoma she showed at the abdominal ultrasound, performed for staging, diffuse thickening of the gallbladder wall , coherent with a chronic cholecystitis and with the mild right-upper-abdominal pain that the patient complained in the last months. After laparoscopic cholecystectomy, the pathology report showed a metastatic lobular carcinoma of the breast. Two years later she presented with SNC metastases and died four months later. Lobular histotype is the most frequent breast neoplasm associated with gallbladder metastases. Usually metachronous, these metastases are sinchronous in 28% of cases. Symptoms are usually ...
Breast carcinoma with asymptomatic metastasis to the gallbladder
Singapore medical journal, 2012
The biliary tract is an unusual site of metastasis from breast carcinoma, and this has rarely been reported in the literature. We report the case of a 42-year-old woman diagnosed with invasive lobular carcinoma of the breast who underwent laparoscopic cholecystectomy for an incidental finding of gallbladder wall thickening on ultrasonography, which was subsequently confirmed to be consistent with metastasis from the breast primary.
Journal of the Egyptian National Cancer Institute, 2016
Background: Gall bladder carcinoma is one of the most common cancers in India. Gall bladder cancer with metastasis to the breast is very rare. Herein we intend to report a case of carcinoma gall bladder with breast metastasis and a short review of the literature. Methods: This report describes an interesting and unusual case of gall bladder carcinoma presenting with breast metastasis. Case report: A 38-year lady presented with complaints of right abdominal pain. Bilateral breast examination showed 2 Â 2 cm palpable lump in the upper outer quadrant of the left breast. Contrast-enhanced CT of the abdomen and pelvis showed circumferential thickening of gall bladder with the loss of fat plane with the adjacent liver parenchyma. Biopsy from the breast lump was reported as metastatic adenocarcinoma compatible with primary in the gall bladder. Whole body PET-CT showed gall bladder mass with abdominal and pelvic nodes with metastasis to liver, left breast, C7 vertebral body and left supra-clavicular node. She was diagnosed to have disseminated carcinoma gall bladder with liver, breast and supraclavicular nodal metastasis. She received palliative chemotherapy with gemcitabine and carboplatin and radiotherapy to C7 vertebra. After receiving 3 cycles of chemotherapy, chemotherapy was changed to the second line with single agent capecitabine. In spite of two lines of chemotherapy, she succumbed to disease progression and expired. Conclusion: There are limited examples of gall bladder adenocarcinoma with simultaneous metastasis to breast in the English literature. Our case showed an unusual dissemination of gall bladder cancer.
Annals of Medical Research, 2022
Aim: Breast tumors usually metastasize to lymph nodes, bone, lung, liver and central nervous system, and rarely to gastrointestinal system (GIS) and gallbladder. In this study, we aimed to present and discuss our breast carcinoma cases with GIS and gallbladder metastases. Material and Methods: Clinicopathological findings of nine breast tumors with metastases to gallbladder and GIS were evaluated in our study. Results: The mean age was 51.2 years. Seven cases, five of which were invasive ductal carcinoma (IDC) and two invasive lobular carcinoma (ILC), had metastases to GIS. In these cases, metastatic foci were mostly observed in stomach, small intestine, sigmoid colon and rectum, respectively. The diagnosis of two cases with metastases to gallbladder was IDC. In two cases, one with gastric and other, with gallbladder metastases, lymph nodes were also involved. All cases died aside from an IDC with gallbladder metastasis and an ILC with gastric metastasis. Conclusion: Metastasis from a breast tumor should be taken into consideration particularly in cases with unknown primary. GIS and gallbladder, though rare, might be the metastatic foci of breast carcinomas.
Case Report: Metastatic breast cancer to the gallbladder
F1000Research, 2020
Cholecystitis is one of the leading causes of emergency surgical interventions; the occurrence of metastases to the gallbladder is rare and has only been reported in the literature exceptionally. Metastatic breast cancer to the gallbladder is even less frequent; in fact, breast cancer usually metastasizes to bone, lung, lymph nodes, liver and brain. We report the case of an 83-year-old female patient with a previous history of breast surgery with axillary dissection in 1997, followed by adjuvant chemotherapy due to invasive ductal carcinoma of the left breast. The patient was admitted at the emergency department for sepsis and an episode of acute kidney failure, anuria and fever. Right-upper quadrant abdominal pain triggered by food intake and abdominal tenderness was also present, placing the diagnostic suspicion of biliary sepsis due to acute cholecystitis. The histological examination of the surgical specimen highlighted the presence of metastasis from an infiltrating ductal breast carcinoma with positive hormone receptors. We also report here the results of a review of the literature looking at articles describing cases of gallbladder metastasis from breast cancer.
Unusual presentation of metastatic gall bladder cancer
Journal of Cancer Research and Therapeutics, 2014
To report the first case of rare isolated breast metastasis from carcinoma gall bladder. Single patient case report. A 35-year-old pre-menopausal female presented with 2 * 2 cm right upper outer quadrant breast lump. Post-mastectomy, histology confirmed it to be metastatic adenocarcinoma positive for both Cytokeratin (CK) 7 and CK20. Past history as told by the patient revealed that 2 years back, cholecystectomy was performed for gall stones, of which no histology reports were present; she had a port site scar recurrence which showed it to be adenocarcinoma. Adjuvant chemotherapy and radiotherapy was advised which the patient did not complete. This is probably the first case reported of isolated breast metastasis from gall bladder carcinoma, diagnosed retrospectively. It also highlights the importance of adjuvant treatment in gall bladder malignancy.