D-Lactic Acidosis: A Review of Clinical Presentation, Biochemical Features, and Pathophysiologic Mechanisms (original) (raw)

D-lactic acidosis is a condition first documented in humans in 1979, characterized by episodes of metabolic acidosis and encephalopathy due to the accumulation of d-lactic acid from colonic fermentation. The diagnosis hinges on distinct clinical features including a high serum anion gap with normal lactate levels and specific gastrointestinal conditions like short bowel syndrome. Effective management includes dietary modifications and intravenous glucose administration, with a focus on understanding the pathophysiology involving carbohydrate malabsorption and bacterial overgrowth.