New strategies to direct therapeutic targeting of PML to treat cancers (original) (raw)

This paper explores new strategies to direct therapeutic targeting of the PML gene, which plays a pivotal role in the pathogenesis of various cancers, particularly Acute Promyelocytic Leukemia (APL). The PML gene, known for its tumor suppressor functions and its association with the PML-RARα fusion protein in APL, is significantly involved in multiple cellular processes, including gene transcription, DNA repair, and apoptosis. Recent insights into its post-translational modifications and regulatory mechanisms highlight its potential as a novel therapeutic target in cancer treatment.