Abstract 52: Characterization of murine intrahepatic cholangiocarcinoma homograft models for therapeutic evaluation (original) (raw)

Cancer Research

Abstract

Introduction: Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive adenocarcinoma derived from bile ducts within the liver. This malignancy accounts for about 10% of cholangiocarcinoma cases and is the second most common primary liver cancer. Effective treatments for iCCA are limited, and they are primarily treated by tumor surgical resection. Regrettably, surgical resection is limited to early-stage disease and has an unfavorable prognosis. Development of novel therapeutic strategies for iCCA is needed to improve outcomes for non-resectable late stage iCCAs. Therefore, establishing suitable animal models for in vivo investigation of oncology and immuno-oncology treatment strategies for iCCA is critical. Methods: The Pten−/- GEMM was generated by CRISPR-Cas9 and crossed with Alb-Cre and LSL-KrasG12D/+ mice. Pathological examination of liver and blood biochemistry were investigated in thirteen GEMM mice. Liver fragments that were enriched with iCCA lesions were inoculated in...

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