CEACAM1/VEGF cross‐talk during neuroblastic tumour differentiation (original) (raw)

The Journal of Pathology, 2007

Abstract

The role of angiogenesis in tumour progression is a major subject in modern oncology and a correlation between angiogenesis and poor outcome has been demonstrated for human neuroblastomas. However, the role of angiogenesis in the maturation phase of neuroblastic tumours has never been considered. Human carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1), a potent pro‐angiogenic factor and mediator of vascular endothelial growth factor (VEGF)‐induced angiogenesis, plays a crucial role during the activation phase of angiogenesis and it has been shown to be expressed in the microvessels of the developing central nervous system as well as in newly formed immature blood vessels in many different tumours and under physiological conditions. The present study has investigated the role of CEACAM1/VEGF‐mediated angiogenesis across the whole spectrum of neuroblastic tumours, from undifferentiated to fully differentiated mature ganglioneuromas. CEACAM1 is peculiarly expressed in...

Giulia Ferrari-toninelli hasn't uploaded this paper.

Let Giulia know you want this paper to be uploaded.

Ask for this paper to be uploaded.