Histopathological spectrum of upper gastrointestinal endoscopic biopsies in a rural teaching hospital (original) (raw)
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Journal of pharmaceutical and biomedical sciences, 2016
Background The pathological conditions of upper gastrointestinal tract (GIT) are responsible for a wide range of morbidity and mortality and are also most commonly encountered disorder in routine clinical practice. Endoscopic visualisation helps in clinical diagnosis, however, it often warrants histopathological correlation of biopsy specimen for accurate final diagnosis. Aim and Objectives To determine the profile of histopathological lesions of upper GIT and to correlate the various histopathological lesions of upper GIT with age, sex and clinical presentation. Materials and Methods The study was conducted in the Department of Pathology in Mahatma Gandhi Medical College and Research Institute, Puducherry on 115 upper gastrointestinal endoscopic biopsies during the period of 1 year from January 2014 to December 2014. Brief clinical data were documented. The biopsies were examined for various inflammatory and neoplastic lesions. The findings were then correlated with the clinical pa...
A wide spectrum of disorders affect the upper gastrointestinal tract and are responsible for a huge number of morbidity and mortality. Upper GI endoscopy together with histopathology plays an important role in the accurate diagnosis and management of these disorders. Hence we conducted a 2 year prospective study in a tertiary health care centre with the aim of identifying different histopathological lesions occurring at this site.We analysed biopsies of 176 patients with respect to age, gender, site of lesion, possible underlying etiology along with findings of endoscopy and histopathology.
IP innovative publication pvt. ltd, 2019
Introduction: With the increasing use of endoscopy, gastrointestinal abnormalities are encountered more often. However it has been realized that endoscopic appearances are not pathognomonic and they need histological confirmation. The objective of this study was to determine the morphological spectrum of upper gastrointestinal tract lesions on histopathology and the correlation between endoscopic and histopathological diagnosis. Materials and Methods: A histopathological study was carried out in 100 endoscopic biopsy specimens of upper gastrointestinal tract lesions. Conventional haematoxylin and eosin staining was done in all the 100 cases. Warthin-Starry stain was done in gastric biopsies, where there was suspicion of Helicobacter pylori (H. pylori) gastritis on histopathology. Results: In our study, out of 100 cases, stomach was the most common site, comprising of 46% of all the cases followed by esophagus (30%) and duodenum (24%).On histology, squamous cell carcinoma of esophagus was found to be the most common lesion with an incidence of 22%, followed by celiac disease (14%), H. pylori gastritis (9%) and fundic gland polyp (8%). Our data suggested that in case of visible growth on endoscopy, the biopsy correlated well with histopathology. However, histopathology significantly improved the diagnosis of inflammatory lesions. Conclusion: Endoscopic procedure in adjunction with histological interpretation remains the mainstay of diagnostic modality in cases of upper gastrointestinal tract lesions.
A Clinicopathological Study of Gastric Malignancy in Endoscopic Biopsy
IOSR Journals , 2019
Gastric carcinoma is common worldwide and also in India. The diagnosis of gastric carcinoma depends on clinical, radiological, biochemical and pathological parameters 1,2 ,. 52 cases of endoscopic biopsy and histopathology positive patients were studied on the aforesaid parameters and clinical records were correlated with histopathology. Age range was 30 to 90 years, predominantly males. Main age group affected for male was 5 th and 6 th decades, and women affected mostly in the age range 36 to 45 years. Clinically dyspepsia and weight loss were commonest symptoms. History of smoking was fairly common(53.86%). 38.46% patients had history of using H2 blocker or proton pump inhibitors.Barium meal xray and ultrasonography results correlated well with histopathology.Most of the cancers occurred in the prepylorus and antrum. Adenocarcinoma was the commonest type (92.3%), followed by lymphoma (3.84%) and leiomyosarcoma (1.92%). The increased incidence of Intestinal type of adenocarcinoma in this region of India indicates this is a high risk area and environmental factors play a major role in causing such type of stomach carcinoma. Proper care, early detection ands long-term follow up may reduce incidence of stomach malignancy in this area.
Evaluation of Upper Gastrointestinal Endoscopic Biopsies
IOSR Journals , 2019
Introduction: The upper gastrointestinal flexible fibreoptic endoscope was a simple, safe and well tolerated procedure. The endoscopic biopsy not only permits exact diagnosis of a specific entity but also provides an opportunity to see H.pylori status and may detect gastric mucosal lesions at an early stage. Aims & Objectives: To study the morphological spectrum of upper gastrointestinal lesions in endoscopic biopsies Materials & Methods: A prospective study of 187 cases for a period of 2 yrs. The material was fixed in 10% formalin routinely processed and stained with H&E Results: Out of 187 cases 34 were esophageal,135 from stomach and 9 each from esophagogastric junction and duodenum. conclusion: squamous cell carcinoma was the commonest malignancy of the esophagus, seen in 6 th and 7 th decade, more frequent in males, had habitual association with betel nut chewing, more common in middle 1/3,presentation being as a stricture ,histologically most are moderately differentiated SCC. .Adenocarcinoma was the commonest malignancy of stomach ,seen in 5 th & 6 th decade ,found to be predominant in males ,antrum was the commonest site, the commonest presentation was ulcerative growth , histologically most are intestinal type of adenocarcinomas, the common predisposing lesion was H.pylori infection.. Cancers of the EGJ presented mostly as polypoid growths and histologically, they were tubular adenocarcinomas. The 2 cases of duodenal adenocarcinomas presented as fleshy and infiltrative growths.The other less common neoplasms of upper GIT include GIST, carcinoid tumor and lymphoma.
Panacea Journal of Medical Sciences, 2023
Abstract Background: Upper gastrointestinal tract (UGIT) comprises of esophagus, stomach and duodenum till the second part. Diseases affecting this region include inflammatory lesions, dysplasias, benign neoplasms and malignancies. Endoscopic biopsy and histopathological examination is considered as gold standard for gastrointestinal disorders. Endoscopic biopsy aids in early diagnosis of malignancy and better patient management. Present study was conducted with an aim of studying various histopathological features of endoscopic biopsies obtained from the UGIT. Materials and Methods: This study was a retrospective study of all UGIT endoscopic biopsies that were received from January 2015 to April 2020. Archived hematoxylin and eosin stained slides were retrieved and reviewed for various morphological abnormalities. Results: During the study period 70 endoscopic biopsies from the UGIT were received. The incidence of malignancy was 74% and non-neoplastic lesions amounted to 26% of the biopsies. Biopsies from the esophagus (63%) constituted the major portion, followed by stomach (34%) and duodenum (3%). Conclusion: In our study incidence of malignancy outnumbered the non-neoplastic conditions. Esophagus was the most commonly biopsied site and squamous cell carcinoma of middle part of the esophagus was the most common malignancy. Inflammatory conditions constituted major part of the non-neoplastic lesions. Keywords: Endoscopic biopsy, Upper gastrointestinal tract, Histopathology
2014
Background and Aims: To examine the association between endoscopic and histological diagnoses concerning malignancies of the gastrointestinal tract. Material and Methods: Two hundred thirthy one patients who underwent upper or lower gastrointestinal system endoscopy and had endoscopic biopsy were recruited retrospectively from the files of our center between the years of 2010 and 2012. The study was based on four types of endoscopic lesions including: mucosal irregularity, ulcerovegetating mass, ulcer and polyp, and four histopathologic diagnoses including polyps, ulcer, gastritis and adenocarcinoma. Results: In all, 199 of 213 (86.1%) patients had gastric and duodenal biopsies and the remaining 32 (13.9%) had colonic and rectal biopsies. The mean age of the patients was 63.5 years and the mean microscopic size of the lesions was 12 mm. Fifty four (23.4%) patients had histopathologic diagnosis of malignancy. Of all the lower gastrointestinal system biopsies, 59.4% were diagnosed as ...