The influence of environmental stimulation in ageing on AD –associated neuropathology and cognitive deterioration (original) (raw)

Abstract

Objective Environmental enrichment (EE) has been proposed to reduce the risk of developing dementia in conditions such as Alzheimer’s disease (AD). The current project investigates the potential of different forms of later-life EE to ameliorate cognitive deterioration in ageing in wildtype (WT) mice as well as in a transgenic model (APP/PS1) of early-stage AD. Method Male transgenic (APPswe, PSEN1dE9) and WT mice entered differential housing from 6 – 12 months of age. Mice entered standard (SH) or EE housing. EE housing comprised a cage double the size of the SH cage, with various enrichment objects. A sub-set of EE mice (EE+) received additional stimulation by spending several hours a week in a larger cage with novel objects. Working memory (Y maze) was tested at 6 months, before entering differential housing, and at 9 and 12 months. At 12 months, mice were also tested for their long-term memory function on the Barnes maze. Results At 6 months, APP/PS1 mice demonstrated inferior Y ...

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