Essential oils for COVID-19 management: A systematic review of randomized controlled trials (original) (raw)
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Contemporary Clinical Trials Communications
A ra nd om iz ed an d co mp ar at iv e st ud y to as se ss sa fe ty an d ef fi ca cy of su pp le me nt al tr ea tm en t of a he rb al fo rm ul at io n-Aa yu dh Ad va nc e co mp ri si ng es se nt ia l oi ls in pa ti en ts wi th co ro na vi ru s 20 19 (C OV ID-19) Ja ye sh Du tt a , Bh av de ep Ga na tr a b , Ni la y Su th ar c , Mo ha mm ed eb ra hi m Ma le k a , Bh ak ti Sh uk la d , Kr up al i Sh uk la d , Ka rn a Sh uk la d , Sh re ya Pa nd it e , Ma ni sh Ra ch ch h f , * , Ri na Go ka ni f , Mo na Bh al an i f
Essential oils a challenge against Covid-19: Review
2021
Currently, the most pressing problem in the world is the SARS-CoV-2 pandemic with the increase in the number of newly infected and deceased patients. Scientists around the world are concerned about finding solutions to treat and prevent the SARS-CoV-2 virus all based on a safe and natural herbal derived medicine. Most essential oils contain molecules with antiviral activity and combine other interesting actions such as immune stimulation or an anti-inflammatory effect. Among the thousands of drugs in development or on the market, there may be effective treatments for the Covid-19 virus. Researchers have been sifting through the computer to identify those that could inhibit the essential interaction that SARS-CoV-2 has with the TMPRSS2 protein to enter our cells.
Molecules
Herbal products are a major source of herbal medicines and other medicines. Essential oils have shown various pharmacological activities, such as antiviral activity, and therefore are proposed to have potential activity against SARS-CoV-2. Due to their lipophilicity, essential oils can easily penetrate the viral membrane and cause the viral membrane to rupture. In addition, crude essential oils usually have many active constituents that can act on different parts of the virus including its cell entry, translation, transcription, and assembly. They have further beneficial pharmacological effects on the host’s respiratory system, including anti-inflammatory, immune regulation, bronchiectasis, and mucolytics. This review reported potential essential oils which could be promising drugs for COVID-19 eradication. Essential oils have many advantages because they are promising volatile antiviral molecules, making them potential drug targets for the prevention and treatment of COVID-19, whet...
Role of Essential Oils in the Management of COVID-19
Zenodo (CERN European Organization for Nuclear Research), 2023
A potential source of herbal drugs and other therapies is herbal goods. Essential oil (EO) may possess therapeutic potential against SARS-CoV-2 due to numerous therapeutic properties, including antiviral activity. Due to its lipophilicity, EO can quickly penetrate through viral capsid results in burst. Moreover, EO typically possesses active constituents triggers numerous targets on virus predominantly entrance, translation and replication. They also have additional advantageous therapeutic effects on host's respiratory system shows anti-inflammatory, immunological modulation, bronchiectasis and mucolytic affect.This Chapter summarizes the potential essential oils which could be promising drugs forCOVID-19 eradication. EO imparts many advantages as promising volatileantiviral molecules may be potential drug targets for the management of COVID-19, either alone/combination with other drugs. The aim of the currentreview is to shed light on the effective EO against viruses and its proposedpotential against SARS-CoV-2.
The management of COVID 19 by plant extracts, essential oils and phytoconstituents: A review
Acta Periodica Technologica, 2022
Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome virus 2 (SARS-CoV-2), it is a virus belonging to the family Coronaviridae which includes zoonotic viruses infecting mammals and birds. This disease emerged in December 2019 in Wuhan, China, and quickly developed into a global pandemic with high mortality rates. The magnitude of the pandemic has involved a global collaborative scientific response to develop effective preventive and therapeutic means using both traditional and advanced techniques. However, to date specific therapies for COVID-19 are not well established and only a few vaccines are approved for emergency use. Herbal remedies, especially essential oils (EOs) can boost immunity which plays a decisive role in the initiation and progression of the disease in the preliminary stage of a COVID-19 infection. The low cost and availability of medicinal plants as well as the almost non-existent side effects encourages their widespread use during the pandemic, hence a great need to identify plant extracts for anti-COVID 19 use. Although the majority of studies are done in silico, with little in vivo or in vitro study, we can have an idea for further later experiments.
Aromatherapy for controlling coronavirus (SARS-CoV-2), 2021
This review paper presented on the basis of extensive literature survey updated the importance of plant essential oils in controlling many diseases, particularly coronavirus (SARS-CoV-2) disease outbreak. Plant essential oils are valuable natural products, and used as a raw materials in aromatherapy, phytotherapy, perfumery, cosmetics, spices and nutrition. Aromatic plants produced a diversity of chemical constituents with the potential to inhibit viral replication. Essential oils have several biological properties such as antibacterial, antifungal, antiviral, antioxidant, anti-inflammatory, wound-healing and anti-cancer effects in in vitro and in vivo. Therefore, essential oils have been analyzed and described as good antiviral agents against respiratory tract viral infections, hence are excellent prospective candidate against coronavirus. Thus, essential oils and their constituents can hopefully be considered in near future for more clinical assessment and possible applications in controlling the coronavirus pandemic. However, some of the plant essential oils are very toxic and poisonous and therefore, oral consumption should be avoided. Further detailed clinical trial experiments should be conducted for the scientific validation.
Turkish journal of pharmaceutical sciences, 2022
Objectives: The lack of a specific proven treatment for coronavirus disease-2019 (COVID-19) has led individuals to use different treatment options. Although their effects on COVID-19 have not been proven, interest in dietary supplements and aromatherapy has increased during the pandemic period. In this study, use of dietary supplements and aromatherapy was investigated for COVID-19 among individuals living within the borders of Türkiye. Materials and Methods: This cross-sectional survey study was conducted among 310 individuals. The questionnaire was prepared using online Google Forms and communicated to the participants via social media platforms. The data obtained from the study were analyzed with the statistical program. Results: The analyzes of the survey revealed that participants increased the usage of supplements mostly prophylactic and for treatment purposes during COVID-19 pandemic, 31.9% individuals declared that they consumed herbal tea/products, 38.1% of them used vitamin/mineral supplements (multivitamin-mineral, vitamins B1, B6, B12, C, D, calcium, coenzyme Q10, iron, magnesium, selenium, and zinc), and 18.4% of the individuals applied aromatherapy (meaning treatment with essential oils). As a result of the study, the most commonly used supplement was vitamin D, the most commonly consumed tea was green tea, the essential oil was thyme oil, and the most eaten vegetable was garlic. Moreover, other frequently used herbal products were found to contain ginger and onion as food and peppermint and eucalyptus oils as aromatherapeutics. Participants often reported that they found it safe to use elevated levels of herbs or herbal products against COVID-19. Conclusion: Among the individuals participating in this study, it has been observed that the use of dietary supplements has increased during the COVID-19 pandemic period. The study revealed that vitamin D is prominent in self-medication use. Moreover, interest in aromatherapy and dietary supplements has increased. Among aromatherapeutics, thyme stood out over the applied essential oils.
CAND Journal
Objective: This living review of systematic reviews investigates the types and volume of research pertaining to natural health products and therapies as they relate to the prevention and/or treatment of COVID-19 and post-COVID syndrome. Methods: A monthly search for published peer-reviewed systematic reviews of the topic was initiated May 2022 and is ongoing. Using a systematic keyword search strategy with clear inclusion and exclusion criteria, a summary of the types of studies included, the overall outcome and treatment focus were assessed. Results: A total of 225 systematic reviews encompassing 5,636 studies of randomized controlled trials (49.8%, n=112), observational studies (21.3%, n=48), clinical studies (20.4%, n=46), and other studies (12%, n=27) were included. Of those, 28.9% (n=65) of the systematic reviews focused on prevention, 67.6% (n=152) on treatment, and 3.1% (n=8) on post-COVID. The natural health products reviewed included herbal medicine, vitamins, minerals, oth...
Analysis of Essential Oils Utilization in Enhancing Immune Systems in the Pandemic Era
2021
In December 2019, a new virus strain of coronavirus-SARS-CoV-2 (COVID-19) has been reported. One prevention that can be done is to increase immune systems by using essential oils. This study aims to analyze the essential oils used during a pandemic. A Qualitative descriptive method with a random sampling technique was used in this study. The questionnaire was distributed through social media with a sample size of 261 people in the West Nusa Tenggara region. Data on the percentage of use of essential oils such as eucalyptus oil 82.6%;lemon oil 14.8%;lemongrass oil 13.9%;lavender oil 9.6%. 72.2% answered that the technique for using this oil is by rubbing and 5.76% by inhaling the oil. The expected benefits by users are to be healthy 58.9%;fresh 23.2%, and 11.6% answered to avoid COVID-19. Meanwhile, there were 96.85% respondents used the oils before the pandemic, and 5.3% used the oils since March to April. 50.4% respondents attained the information from social media and 49.6% from f...
Zanjan University of Medical Sciences, 2021
Background and Objective: SARS COV-2 is a worldwide pandemic disease. There is currently no effective cure for this virus, but some types of herbs can be a good choice for reducing its symptoms. There are some reports that Thymus Vulgaris has a high antioxidant compounds effective in strengthening the immune system, as well as anti-virus effects to reduce the respiratory symptoms. Therefore, we speculated that Thymus Vulgaris could be useful for reducing some of the symptoms in patients suffering from COVID- 19. Materials and Methods: First, thyme essential oil was prepared and a questionnaire regarding the patients’ symptoms was designed. Then, 83 patients with COVID-19 were randomly selected and divided into control group and thyme receiving group (TRG). The questionnaire was completed and emphasized to consume 5 mL of the syrup or essential oil three times per day. Finally, one week after the first visit, the questionnaire was completed again to determine the effects of thyme on the mentioned symptoms. Finally, the test results were reviewed and reported. Results: The results one week after taking thyme showed that, the fever (p<0.027), dizziness (p<0.003), cough, dyspnea, muscular pain, headache, anorexia, weakness and lethargy, fatigue, and chest wall pain were significantly reduced (p<0.001). Also, BUN (p<0.004), neutrophil count (p<0.001), and calcium (p<0.034) decreased but, lymphocyte count was increased significantly (p<0.001). Conclusion: Thyme plant which has high antioxidant properties, strengthens the immune system, and induces the antiviral effect could reduce the symptoms of coronavirus; therefore, it is recommended for reducing the symptoms of COVID-19. Keywords: COVID-19, Thyme, Thymus Vulgaris, Persian Medicine, Respiratory