A short-term evaluation of a thermoplastic polyurethane implant for osteochondral defect repair in an equine model (original) (raw)

Abstract

Highlights  Osteochondral defects lead to fibrous repair tissue and deterioration of the surrounding cartilage  A synthetic implant of appropriate stiffness that allows the repair tissue to fill the defect could prevent deterioration  The implant was well tolerated in the stifle joints of Shetland ponies and resulted in stiff, flush repair tissue  Despite promising results in vitro, no hyaline-like cartilage matrix was formed on the polyurethane after 12 weeks  Long-term follow-up is needed to evaluate the potential of this bi-layered

Loading...

Loading Preview

Sorry, preview is currently unavailable. You can download the paper by clicking the button above.

References (30)

  1. Bal, B.S., Rahaman, M.N., Jayabalan, P., Kuroki, K., Cockrell, M.K., Yao, J.Q., Cook, J.L., 2010. In vivo outcomes of tissue-engineered osteochondral grafts. Journal of Biomedical Materials Research Part B, Applied Biomaterials 93, 164-174.
  2. Benders, K.E., Boot, W., Cokelaere, S.M., Van Weeren, P.R., Gawlitta, D., Bergman, H.J., Saris, D.B., Dhert, W.J., Malda, J., 2014. Multipotent stromal cells outperform chondrocytes on cartilage-derived matrix scaffolds. Cartilage 5, 221-230.
  3. Convery, F.R., Akeson, W.H., Keown, G.H., 1972. The repair of large osteochondral defects. An experimental study in horses. Clinical Orthopaedics and Related Research 82, 253-262.
  4. Custers, R.J., Dhert, W.J., van Rijen, M.H., Verbout, A.J., Creemers, L.B., Saris, D.B., 2007. Articular damage caused by metal plugs in a rabbit model for treatment of localized cartilage defects. Osteoarthritis and Cartilage 15, 937-945.
  5. Harris, J.D., Siston, R.A., Pan, X., Flanigan, D.C., 2010. Autologous chondrocyte implantation: a systematic review. The Journal of Bone and Joint Surgery, American Volume 92, 2220-2233.
  6. Heinemeier, K.M., Schjerling, P., Heinemeier, J., Moller, M.B., Krogsgaard, M.R., Grum- Schwensen, T., Petersen, M.M., Kjaer, M., 2016. Radiocarbon dating reveals minimal collagen turnover in both healthy and osteoarthritic human cartilage. Science Translational Medicine 8, 346ra90.
  7. Hollister, S.J., 2005. Porous scaffold design for tissue engineering. Nature Materials 4, 518- 524.
  8. Hunziker, E.B., 1999. Articular cartilage repair: Are the intrinsic biological constraints undermining this process insuperable? Osteoarthritis and Cartilage 7, 15-28.
  9. Husby, K.A., Reed, S.K., Wilson, D.A., Kuroki, K., Middleton, J.R., Hoepp, N.C., Charles, E.M., Cook, J.L., 2016. Evaluation of a permanent synthetic osteochondral implant in the equine medial femoral condyle. Veterinary Surgery 45, 364-373.
  10. Jackson, D.W., Lalor, P.A., Aberman, H.M., Simon, T.M., 2001. Spontaneous repair of full- thickness defects of articular cartilage in a goat model. A preliminary study. The Journal of Bone and Joint Surgery, American Volume 83A, 53-64.
  11. Katagiri H., Mendes L.F., Luyten F.P., 2017. Definition of a critical size osteochondral knee defect and its negative effect on the surrounding articular cartilage in the rat. Osteoarthritis and Cartilage 25, 1531-1540.
  12. Krych, A.J., Robertson, C.M., Williams, R.J.,3rd, Cartilage Study Group, 2012. Return to athletic activity after osteochondral allograft transplantation in the knee. The American Journal of Sports Medicine 40, 1053-1059.
  13. Malda, J., Benders, K.E., Klein, T.J., de Grauw, J.C., Kik, M.J., Hutmacher, D.W., Saris, D.B., van Weeren, P.R., Dhert, W.J., 2012. Comparative study of depth-dependent characteristics of equine and human osteochondral tissue from the medial and lateral femoral condyles. Osteoarthritis and Cartilage 20, 1147-1151.
  14. Mancini, I.A.D., Vindas Bolanos, R.A., Brommer, H., Castilho, M., Ribeiro, A., van Loon, J.P.A.M., Mensinga, A., van Rijen, M.H.P., Malda, J., van Weeren, R., 2017. Fixation of hydrogel constructs for cartilage repair in the equine model: A challenging issue. Tissue Engineering Part C: Methods 23, 804-814.
  15. McAdams, T.R., Mithoefer, K., Scopp, J.M., Mandelbaum, B.R., 2010. Articular cartilage injury in athletes. Cartilage 1, 165-179.
  16. McIlwraith, C.W., Fortier, L.A., Frisbie, D.D., Nixon, A.J., 2011. Equine models of articular cartilage repair. Cartilage 2, 317-326.
  17. McIlwraith, C.W., Frisbie, D.D., Kawcak, C.E., Fuller, C.J., Hurtig, M., Cruz, A., 2010. The OARSI histopathology initiative -Recommendations for histological assessments of osteoarthritis in the horse. Osteoarthritis and Cartilage 18 Suppl. 3, S93-105.
  18. Miller, R.E., Grodzinsky, A.J., Barrett, M.F., Hung, H.H., Frank, E.H., Werpy, N.M., McIlwraith, C.W., Frisbie, D.D., 2014. Effects of the combination of microfracture and self-assembling peptide filling on the repair of a clinically relevant trochlear defect in an equine model. The Journal of Bone and Joint Surgery, American Volume 96, 1601-1609.
  19. Palmer J.L., Bertone A.L., Mansour J., Carter B.G., Malemud C.J., 1995. Biomechanical properties of third carpal articular cartilage in exercised and nonexercised horses. Journal of Orthopedic Research 13, 854-860.
  20. Peterson, L., Vasiliadis, H.S., Brittberg, M., Lindahl, A., 2010. Autologous chondrocyte implantation: A long-term follow-up. The American Journal of Sports Medicine 38, 1117-1124.
  21. Reyes, C.D., Petrie, T.A., Burns, K.L., Schwartz, Z., Garcia, A.J., 2007. Biomolecular surface coating to enhance orthopaedic tissue healing and integration. Biomaterials 28, 3228-3235.
  22. Schagemann, J.C., Rudert, N., Taylor, M.E., Sim, S., Quenneville, E., Garon, M., Klinger, M., Buschmann, M.D., Mittelstaedt, H., 2016. Bilayer implants: Electromechanical assessment of regenerated articular cartilage in a sheep model. Cartilage 7, 346-360.
  23. Shimomura, K., Moriguchi, Y., Ando, W., Nansai, R., Fujie, H., Hart, D.A., Gobbi, A., Kita, K., Horibe, S., Shino, K. et al., 2014. Osteochondral repair using a scaffold-free tissue-engineered construct derived from synovial mesenchymal stem cells and a hydroxyapatite-based artificial bone. Tissue Engineering Part A 20, 2291-2304.
  24. Steadman, J.R., Rodkey, W.G., Rodrigo, J.J., 2001. Microfracture: Surgical technique and rehabilitation to treat chondral defects. Clinical Orthopaedics and Related Research Suppl. 391, 362-369.
  25. Van Loon, J.P., Van Dierendonck, M.C., 2015. Monitoring acute equine visceral pain with the Equine Utrecht University Scale for Composite Pain Assessment (EQUUS- COMPASS) and the Equine Utrecht University Scale for Facial Assessment of Pain (EQUUS-FAP): A scale-construction study. The Veterinary Journal 206, 356-364.
  26. van Weeren, P.R., Back, W., 2016. Musculoskeletal disease in aged horses and its management. Veterinary Clinics of North America: Equine Practice 32, 229-247.
  27. Vindas Bolaños, R.A., Cokelaere, S.M., Estrada McDermott, J.M., Benders, K.E., Gbureck, U., Plomp, S.G., Weinans, H., Groll, J., van Weeren, P.R., Malda, J., 2017. The use of a cartilage decellularized matrix scaffold for the repair of osteochondral defects: The importance of long-term studies in a large animal model. Osteoarthritis and Cartilage 25, 413-420.
  28. Visser, J., Levett, P.A., te Moller, N.C., Besems, J., Boere, K.W., van Rijen, M.H., de Grauw, J.C., Dhert, W.J., van Weeren, P.R., Malda, J., 2015. Crosslinkable hydrogels derived from cartilage, meniscus, and tendon tissue. Tissue engineering Part A 21, 1195-1206.
  29. Yang, Z., Shi, Y., Wei, X., He, J., Yang, S., Dickson, G., Tang, J., Xiang, J., Song, C., Li, G., 2010. Fabrication and repair of cartilage defects with a novel acellular cartilage matrix scaffold. Tissue engineering Part C: Methods 16, 865-876.
  30. Zhao, X., Papadopoulos, A., Ibusuki, S., Bichara, D.A., Saris, D.B., Malda, J., Anseth, K.S., Gill, T.J., Randolph, M.A., 2016. Articular cartilage generation applying PEG-LA- DM/PEGDM copolymer hydrogels. BMC Musculoskeletal Disorders 17, 245-016- 1100-1.