Current approaches to the therapy of vulvovaginites taking into account antibiotic resistance to the infectious agents (original) (raw)
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Recurrent vulvovaginitis and vaginosis. Possibilities of effective therapy
Gynecology, 2020
Infectious and inflammatory diseases of the genitals caused by various opportunistic and pathogenic microorganisms arefound in 70% of all gynecological patients who seek help from medical institutions. Currently, scientists and clinicians in their practice are increasingly faced with insufficient effectiveness of treatment of vulvovaginitis and vaginosis, a tendency to a long and protracted course, recurrence of the process. One of the reasons for the longer and more severe course, the recurrence of the process is the increasingly common mixed infection with the possible simultaneous predominance of aerobes, anaerobes, andCandidafungi, which suggests the appointment of appropriate drugs. One of these drugs is Tergynan, which demonstrates a good clinical effect and tolerability of the drug in the treatment of recurrent vulvovaginitis and dysbiotic conditions of the lower genital tract.
Bacterial vaginosis: modern concepts, approaches to diagnosis and treatment
Gynecology, 2021
Microbiota a set of human microorganisms that exist with him in normal and pathological conditions, are involved in physiological and pathophysiological reactions, metabolism. The classic manifestation of a violation of the vaginal microbiota is a clinical non-inflammatory syndrome bacterial vaginosis (BV), characterized by certain changes in the composition of the vaginal microbiota and excessive reproduction of microorganisms, which are normally present in small quantities. To date, literature data emphasize that the issues of the etiology, pathogenesis of BV, the reasons for the recurrence of the process are not fully understood, the reasons for the lack of long-term effectiveness of BV therapy are unknown. Further research in this area should be aimed at studying predictors and prognostic signs of recurrence and persistence of the process, differences in vaginal microbiota in patients with recurrent and persistent BV.
Non-specific chronic vaginites in women of the industrial center and ways of their correction
Dermatovenerology. Cosmetology. Sexopathology
Insufficient effectiveness of antibacterial and antiinflammatory therapy dictates the need to find new ways of prevention and treatment of chronic recurrent inflammatory diseases of the vagina and cervix in women with the use of new generation multiprobiotics. Objective of the study: evaluation of the effectiveness of the use of a multipropiotic drug with propolis in the treatment of recurrent bacterial vaginitis in women of reproductive age - residents of a large industrial city. Materials and methods of the study: 69 patients aged 18 - 45 years with bacterial vaginitis living in the large industrial city of Zaporizhzhya were observed. The main group consisted of 14 women with inflammatory diseases of the vagina and cervix, who received in the complex treatment of multiprobiotics with propolis 1 dose 1 time a day in the vagina for 5 days. To determine the presence of an infectious agent, microscopic and bacteriological examination of vaginal and cervical canal secretions was perf...
Use of Linezolid in the treatment of surgical infectious complications under antibiotic resistance
Perioperaciina Medicina, 2021
Linezolid – a first representative of the new class of synthetic antibiotics oxazolidones. Its antibacterial spectrum includes Gram-positive microorganisms, including multi-resistant strains. Its unique mechanism of action conditions absence of cross-resistance with other antibiotics. This drug is presented in peroral and parenteral forms. Unlike vancomycin, it has optimal pharmacokinetic profile. Linezolid was approved by Food and Drug Administration (FDA) in 2000 for the treatment of the following diseases: hospital- and community-acquired pneumonia, skin and soft tissue infections with or without complications caused by Gram-positive bacteria, vancomycin-resistant enterococci and pneumococcal meningitis, caused by penicillin-resistant Streptococcus pneumoniae.
Russian Journal of Infection and Immunity
Inflammatory diseases of the vagina related to imbalanced microflora composition represent one of the most common gynecological diseases primarily dealt with by obstetrician/gynecologists. Such diseases markedly worsen female patient quality of life as well as affect female reproductive system resulting both in altered fertility and adverse pregnancy outcomes. By now, multiple therapeutic and preventive protocols have been proposed to manage such diseases, but insufficient therapeutic efficacy and frequent relapses require further investigations. The aim of the study was to evaluate an effect of the drug Elgyna (Wertex, Russia) consisting of antibacterial, antifungal and glucocorticoid agents on local immunity in females with bacterial vaginosis and nonspecific vaginitis. For this, there were examined and treated 24 females enrolled to the study, who underwent gynecological examination (speculum and bimanual vaginal examination), cervical epithelium microscopy, and calculating karyo...
Current knowledge of bacterial vaginosis
Srpski arhiv za celokupno lekarstvo, 2011
Bacterial vaginosis, earlier termed nonspecific vaginitis (anaerobic vaginosis) because of the absence of recognized pathogens, is most common vaginal syndrome of women of childbearing age affecting 15-30%. This syndrome, whose aetiology and pathogenesis remains unknown, is characterized by significant changes in the vaginal ecosystem. These changes consist of a decrease in the number of lactobacilli and a large increase in the number of anaerobic organisms. The bacteria adhere to desquamated epithelial cells with a distinctive appearance of clue cells The main complaints of women with symptomatic bacterial vaginosis include vaginal discharge and odour. However, a significant number of all women who have bacterial vaginosis deny symptoms. Bacterial vaginosis is associated with a number of gynaecologic and obstetric complications including cervicitis, cervical neoplasia, pelvic inflammatory disease, postoperative infections, and preterm labour. The diagnosis is most frequently made b...
Gynecology, 2020
Relevance. Empirical treatment of vaginitis is indicated due to its polymicrobial etiology and limited microbiological analysis. The aim of the study was to study the combination of ornidazoleneomycinprednisoloneeconazole (ONPE, Elzhina) as a first-line drug for local treatment of patients with various forms of non-specific vaginitis. Materials and methods. The study included 55 non-pregnant women aged 18 to 50 years (381.5 years) who had clinical and laboratory signs of acute vaginitis. Results. All patients at the initial treatment complained of pathological discharge, 47 (85.5%) noted itching, burning, pain in the genital area of various degrees of severity, 17 (30.9%) discomfort when urinating, 9 (16.4%) unpleasant smell, 8 (14.5%) dyspareunia, 4 (2.2%) complained of sensations of a foreign body in the vagina. The clinical and laboratory effectiveness of treatment was 89.1% (49). In 6 (10.9%) patients, clinical improvement was noted, with the remaining laboratory signs of aerobi...
Objectives. To determine the effectiveness of the integrated treatment of pyogenic wounds depending on the ability of the isolated pathogen to form biofilm. Methods. During the research, the comprehensive examination and treatment of 48 patients with pyogenicinflammatory processes of soft tissues have been conducted in the Republican Scientific and Practical Center “Infection in Surgery” on the basis of the pyogenic surgery department of ME “Vitebsk Regional Clinical Hospital” during the period of 2012-2014. The control group patients (n=31) were subjected to a standard treatment, the main group patients (n=17) received the suggested integrated treatment of the pyogenic wounds taking into account the ability of pathogens to form biofilm based on the application of the vacuum-instillation therapy with the dimeksid solution as a rinsing liquid. There were no reliable differences in age, sex as well as in nosologic forms of diseases in the investigated groups. Results. Antiseptics widely used in clinical practice have been studied. Dimeksid, inol, isopropyl alcohol destroied the biofilm most intensively. These antiseptics are considered to be recommended for treatment of wounds, associated with pathogens capable to form biofilm. Statistically significant reduction term of the clearance wound, the appearance of granulation tissue, the marginal epithelialization beginning and the length of treatment in the patients underwent the integrated treatment of the pyogenic wounds according to the worked out method have been revealed. Conclusion. The performed research has proved the efficacy of the suggested method of pyogenic wounds treatment taking into account the ability of some pathogens to form biofilm. The application of proposed method can reduce treatment terms of patients with pyogenic wounds by 6 days (p=0,03). Keywords: surgical infection, chronic and acute wound, biofilm
Efficiency of fenticonazole for the treatment of vaginal candidiasis
Srpski arhiv za celokupno lekarstvo, 2012
Introduction. Uncomplicated vulvovaginal candidiasis appears in 75% women of reproductive age. The most frequent causes are Candida albicans (85-95%) or C. glabrata, and infrequently C. krusei, C. tropicalis, C. parapsilosis, C. pseudotropicalis, etc. Objective. The aim of the study was to investigate efficiency and safety of fenticonazole for vaginal candidiasis treatment. Methods. Therapeutic effect of a single 600 mg fenticonasole vaginal capsule was observed in 417 women, aged 16-67, in five centers in Serbia. In all women, before the treatment, vaginal candidiasis was confirmed by testing of vaginal smear. Based on smear findings and associated symptoms observed on the 7th and 28th day after therapy administration, treatment results were evaluated. On the next day after drug application the patients recorded by using a questionnaire their own feelings on withdrawal symptoms and possible side effects in the period prior to the first control. Results. Control after seven days sho...
Acta Naturae, 2020
The spread of antibiotic resistance among pathogens represents a threat to human health around the world. In 2017, the World Health Organization published a list of 12 top-priority antibiotic-resistant pathogenic bacteria for which new effective antibiotics or new ways of treating the infections caused by them are needed. This review focuses on Acinetobacter baumannii, one of these top-priority pathogens. The pathogenic bacterium A. baumannii is one of the most frequently encountered infectious agents in the world; its clinically significant features include resistance to UV light, drying, disinfectants, and antibiotics. This review looks at the various attempts that have been made to tackle the problem of drug resistance relating to A. baumannii variants without the use of antibiotics. The potential of bacteriophages and antimicrobial peptides in the treatment of infections caused by A. baumannii in both planktonic and biofilm form is assessed. Such topics as research into the deve...