Hyperparathyroidism: Unusual location of brown tumors (original) (raw)
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A Rare Presentation of Primary Hyperparathyroidism: Generalized Brown Tumors
Turkish Journal of Osteoporosis
Primer hiperparatiroidizm, günümüzde yaygın ve kolay teşhis edilebilen bir hastalıktır. Neyse ki, kahverengi tümör şeklinde komplikasyonla karşılaşılması nadirdir. Aşağıda, diz ağrısı ile başvuran ve asimetrik yerleşimli kahverengi tümörleri olan primer hiperparatiroidizmli bir olgu sunduk. Paratiroid adenomu radyolojik olarak tespit edildi, ardından minimal invaziv paratiroidektomi ile başarıyla ameliyat edildi. Kahverengi tümörler ameliyattan sonra geriledi. Primer hiperparatiroidizmin hala yaygın kemik tutulumu ile ortaya çıkabildiği ve uygun tedavi ile klinik ve radyolojik olarak iyileştirilebileceği anlaşılmaktadır.
Multifocal Brown Tumor Revealing Primary Hyperparathyroidism
International Journal of Advanced Research, 2019
interne Premier centre médico chirurgical-Agadir. 2. Service ORL Premier centre médico chirurgical-Agadir. 3. Service de réanimation Premier centre médico chirurgical-Agadir. 4. Service d'ophtalmologie Premier centre médico chirurgical-Agadir.
Primary hyperparathyroidism having multiple Brown tumors mimicking malignancy
Indian Journal of Endocrinology and Metabolism, 2012
Primary hyperparathyroidism is a disease characterized by excessive secretion of parathormone. During the course of this disease, bone loss occurs, particularly depending on resorption of the skeletal system. One of the complications of primary hyperparathyroidism is fi brotic, cystic bony changes which is called Brown tumor. Skeletal manifestations in the form of Brown tumors are rare and according to literature occur in less than 2% of patients suffering from any form of hyperparathyroidism. Such rare and multiple benign lesions may simulate a malignant neoplasm and pose a real challenge for the clinician in its differential diagnosis. We present a case of a 23-year-old Indian woman who was evaluated for multiple lytic expansile lesions with a strong suspicion of malignancy and fi brous dysplasia but turned out to be a case of primary hyperparathyroidism.
Tertiary Hyperparathyroidism Inducing Brown Tumour: A Rare Case
2016
Brown tumours (BTs), also known as osteitis fibrosa cystica, are non-neoplastic giant cell lesions which appear in the advanced stage of hyperparathyroidism. Patients with giant cell lesions should be screened for serum calcium, parathyroid hormone (PTH) and alkaline phosphatase. The BT may affect any part of the skeleton but is frequently found in long bones, pelvic girdle, clavicle, ribs and the mandible. The authors present a rare case of BT in tertiary hyperparathyroidism (THP) involving bilateral maxilla, left maxillary sinus, lateral wall of the nose, floor of the orbit and bilateral mandible in a 28-year-old male patient.
Tertiary hyperparathyroidism with multiple Brown tumors mimicking malignancy
Scholars Academic Journal of Biosciences, 2016
Brown tumors are an uncommon type of benign osteolytic bone lesions that occur in hyperparathyroidism, which is an endocrine disease characterized by excessive secretion of the hormone parathormone. They occur more in primary hyperparathyroidism and are seen to regress after removal of parathyroid adenomas. In our report, we describe a a case of tertiary hyperparathyroidism with multiple lytic lesions of the right great toe, left fibula, twelfth posterior rib on right side and base of middle phalanx of left hand. This report illustrates the importance of taking brown tumor in differential diagnosis in patients with multiple lytic lesions, occurring in the backdrop of chronic kidney disease, where a failure to establish an accurate diagnosis may lead to further unnecessary and painful diagnostic procedures and even extensive surgery.
Brown Tumor: A Late Complication of Secondary Hyperparathyroidism
Biomedical Journal of Scientific & Technical Research, 2018
Brown tumor is characterized by atypical non-neoplastic bone lesions caused by an accelerated osteoclastic activity and peritrabecular fibrosis due to hyperparathyroidism, resulting in a local damage phenomenon. It is more common in large bones, ribs and pelvis, but can occur in any bone. We describe a case of a 55-year-old woman undergoing hemodialysis for eight years, with development of a lingual mass in the floor of the mouth, which was histologically diagnosed as a brown tumor. Radiological e clinical features are also described. Brown Tumor requires an early diagnosis and multidisciplinary follow up to avoid fractures, deformities and functional alterations.
Tertiary Hyperparathyroidism Presenting as Multifocal Brown Tumors: A Case Report
Journal Of Endocrinology And Metabolism Research, 2023
Brown Tumor (BT) of the bone is a rare manifestation of hyperparathyroidism (HPTH), an unusual reactive bone lesion attributed to disturbed bone remodeling, from long-standing increase in parathyroid hormone level (PTH). Historically, BTs were described with primary HPTH but due to early diagnosis of this entity, and improved survival in patients with end-stage renal disease (ESRD) especially those on renal replacement therapy (RRT), more cases of BT are now described in this population, and less in PHPTH. Thus, it is mostly the consequence of untreated secondary or tertiary HPTH whose major culprits are chronic kidney disease (CKD) and ESRD. The management of brown tumors related to chronic renal failure consists primarily of its prevention through the use of phosphate binders, vitamin D analogues, and calcimimetics with surgical parathyroidectomy reserved as the final resort in refractory cases. Herein, we present the case of a 24-year-old female patient with ESRD on intermittent hemodialysis (IHD) who developed recent onset facial tumefaction. Blood work revealed markedly elevated PTH at more than 5000 pg/ml, upper borderline hypercalcemia, and hyperphosphatemia. Further investigations with chest computed tomography (CT) and Technetium-99m (99mTc)- Sestamibi scan nuclear imaging showed multiple ribs lytic lesions as well as features of extensive BT and parathyroid adenomas. Thereafter, the patient was sent for parathyroidectomy after which the patient developed hungry bone syndrome.t developed hungry bone syndrome.
Multiple Brown Tumors in a Normocalcemic Patient with Primary Hyperparathyroidism - A Case Report
Bangladesh Journal of Nuclear Medicine, 2019
Brown tumor is a benign bone lesion that arises as a direct result of parathyroid hormone on bony tissue in some patients with hyperparathyroidism. Multiple brown tumors may simulate malignant disease and it is a real challenge for the clinicians in the differential diagnoses. Brown tumor as the only and initial symptom of normocalcemic primary hyperparathyroidism is a rare clinical entity. Here, we present a case with multiple brown tumors in a young normocalcemic woman as a sequele of primary hyperparathyroidism mimicking bone metastases. Bangladesh J. Nuclear Med. 22(1): 68-72, Jan 2019
Brown tumor as a result of secondary hyperparathyroidism in chronic renal disease
JORDI - Journal of Oral Diagnosis, 2016
Introduction: Brown tumor is a focal lesion of giant cells that develops in association with hyperparathyroidism. Objective: To report a case of brown tumor that occurred in the mandibular symphysis region, associated with secondary hyperparathyroidism. Case report: A 45-year-old male patient with chronic renal failure exhibited increased volume with comorbid local paresthesia in the mandibular symphysis region. Radiographs showed a unilocular radiolucent area with partially defined edges in the anterior mandible region. The histopathological findings revealed connective tissue, rich in oval, notched cells and giant cells with hemosiderin pigments. Laboratory tests showed increased serum levels of parathyroid hormone. An attempt to control the hormone levels with medication while the patient awaited a kidney transplant was unsuccessful. Therefore, as a transplant was not imminent and injury continued to develop, the lesion was surgically excised. Three years later, the lesions recurred in the paranasal region. Following partial removal of the lesions, the patient is now under follow-up care. Conclusion: Correct diagnosis and effective treatment of brown tumor requires correlation of biochemical data with the patient's clinical, imaging, and histological profile.
Journal of the Pakistan Medical Association, 2021
Brown tumor (BT) is the pathological expression of osteitis fibrosa cystica owing to primary and secondary hyperparathyroidism (HPT). It is a rare benign lesion of skeletal system that usually affects the facial bones, clavicles, ribs, pelvis and extremities. The purpose of this case report is to present the clinical, pathological and radiological findings of BT, rarely seen in adults, originating from the giant parathyroid adenoma and emerging as the first clinical sign of HPT. The patient underwent a successful parathyroidectomy operation and on the first postoperative day, the patient was discharged without any complications. Continuous...