p rinciples for the post-GWA s functional characterization of cancer risk loci (original) (raw)

AI-generated Abstract

This article discusses the challenges and strategies in post-GWAS functional characterization of cancer risk loci, emphasizing the need for a systematic approach to understanding the complex genetic underpinnings of cancer. It highlights that the majority of identified risk variants reside in non-coding regions, complicating the determination of their functional roles. The authors propose principles to enhance functional characterization, particularly focusing on the transcriptional effects of genetic variants, which could ultimately lead to better clinical outcomes such as biomarkers and preventive strategies.

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