GERO Cohort Protocol, Chile, 2017–2022: Community-based Cohort of Functional Decline in Subjective Cognitive Complaint elderly (original) (raw)
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Subjective Cognitive Impairment Cohort (SCIENCe): study design and first results
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We aimed to describe the Subjective Cognitive Impairment Cohort (SCIENCe) study design, to cross-sectionally describe participant characteristics, and to evaluate the SCD-plus criteria. The SCIENCe is a prospective cohort study of subjective cognitive decline (SCD) patients. Participants undergo extensive assessment, including cerebrospinal fluid collection and optional amyloid positron emission tomography scan, with annual follow-up. The primary outcome measure is clinical progression. Cross-sectional evaluation of the first 151 participants (age 64 ± 8, 44% female, Mini-Mental State Examination 29 ± 2) showed that 28 (25%) had preclinical Alzheimer's disease (AD) (amyloid status available n = 114 (75%)), 58 (38%) had subthreshold psychiatry, and 65 (43%) had neither. More severe subjective complaints were associated with worse objective performance. The SCD-plus criteria age ≥ 60 (OR 7.7 (95% CI 1.7-38.9)) and apolipoprotein E (genotype) e4 (OR 4.8 (95% CI 1.6-15.0)) were asso...
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Journal of Aging and Health, 2011
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Demographic characteristics of subjective cognitive decline studies’ samples. A systematic review
São Paulo Medical Journal, 2021
Background: Subjective cognitive decline (SCD) consists on self-perception of cognition decline without an objective impairment. It has gotten attention from researchers because it may be an early stage of Alzheimer’s disease, before dementia Objectives: This research aimed to determine the characteristics of the SCD studies’ samples across the countries. Methods: It was searched for complete articles from 2014 to 2020 on MEDLINE, PubMed, EMBASE and others, using the keyword “Subjective Cognitive Decline” and its respective translations in both Spanish and Portuguese. Results: Of 3,470 papers, 487 were eligible. The mean age of SCD participants was 71.98 in 2014 to 66.14 in 2020, (mean 66.81) as the number of participants, there were 104 in 2014 and 5233 in 2020 (mean: 1729), and 59% of the participants were women. The mean scholar years were 13.4, in 2014 there were 8 articles and 167 in 2020. Conclusions: The increased number of publications and samples represents the crescent imp...
The Journals of Gerontology: Series A
Background Approximately 77% of older adults with dementia in Brazil have not been diagnosed, indicating a major public health issue. Previous epidemiological dementia studies in Brazil were based on data from 1 geopolitical region. Methods We aimed to estimate the general and subgroup-specific (age, education, and sex) prevalence of dementia and cognitive impairment no dementia (CIND) classification using data from 5 249 participants aged 60 years and older from the ELSI-Brazil, a large nationally representative sample. Participants were classified as having normal cognitive function, CIND, or dementia based on a combination of the individual’s cognitive and functional status. Results We found a general prevalence of 5.8% (95% CI = 4.7–7.2) for dementia and 8.1% (95% CI = 6.8–9.5) for CIND. Dementia prevalence ranged from 3.2% (60–64 years old) to 42.8% (≥90 years old) by age, and from 2.1% (college level or higher) to 16.5% (illiterates) by education. Females had a higher dementia...
2020
Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer`s disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across international cohorts. Therefore, we combined individual participant data for 16 cohorts from 15 countries (members of the COSMIC consortium) and used qualitative and quantitative (Item Response Theory/IRT) harmonization techniques to estimate SCD prevalence. The sample comprised 39,387 cognitively unimpaired individuals above age 60. The prevalence of SCD across studies was around one quarter with both qualitative harmonization/QH (23.8%, 95%CI=23.3%-24.4%) and IRT (25.6%, 95%CI=25.1%-26.1%); however, prevalence estimates varied largely between studies (QH: 6.1%, 95%CI=5.1%-7.0%, to 52.7%, 95%CI=47.4%-58.0%; IRT: 7.8%, 95%%CI=6.8%-8.9%, to 52.7%, 95%CI = 47.4%-58.0%). Across studies, SCD prevalence was higher in men than women, in lower levels of education, i...
Journal of Alzheimer's Disease, 2019
Subjective cognitive complaints in cognitively normal individuals are a relevant predictor of Alzheimer's disease (AD), cerebrovascular disease, and age-related tauopathy. Complaints starting after the age of 60 increase the likelihood of preclinical AD. However, this criterion is arbitrary and current data show that neurodegenerative disorders likely start before that age. Further, data on the role of subjective complaints below the age of 60 in individuals qualifying for subjective cognitive decline (SCD) are lacking. We investigated the association of subjective cognitive complaints with an extensive number of neuroimaging, demographic, clinical, and cognitive measures in individuals fulfilling criteria for SCD below and above the age of 60. Nine complaints were scored in 416 individuals. Complaints were related to a higher load of white matter signal abnormalities, and this association was stronger the more subclinical changes in personality, interest, and drive were reported. In individuals <60 years, complaints were associated with lower global cognitive performance. In individuals ≥60 years, complaints were related to greater global brain atrophy and smaller total intracranial volume, and this association was stronger the more subclinical difficulties in activities of daily living were reported. Also, complaints were associated with increased depressive symptomatology irrespective of age. We conclude that complaints below the age of 60 may be associated with subtle signs of brain pathology. In the community, screening for risk of future cognitive decline should include subjective cognitive complaints, depressive symptomatology, and subclinical reduced cognition (<60 years)/activities of daily living (≥60 years), supported by basic neuroimaging examinations.