Parasitemia and antimalarial-induced histological alterations and oxidative stress in infected mice (original) (raw)

2014, Scientific Journal of Animal Science

In lieu of the reports on re-emergence of chloroquine sensitivePlasmodium falciparum, the choice of the drug for the treatment of malariaespecially in the endemic areas may not be ruled out. Here, we reported the antioxidative statusand histology of some vital organs in mice infected with P. berghei and subsequentlytreated with chloroquine. The study was a 4 by 10 model design as follows, thecontrol non-infected, the infected (IN) and chloroquine-treated infected(CqTI)/non-infected (CqTNI) mice. The challenged animals were subjected to fivedays treatment after parasitemia was established using Gemsa stain. Assays wereconducted on the animals following standard procedures. The results showed thatparasitemia and Chloroquine induced oxidative stress in (IN) and (CqTNI)groups. This was indicated by significant (p<0.05) changes in theantioxidant defence indices viz superoxide dismutase (SOD), reduced glutathione(GSH), glutathione-S-transferase (GST), catalase (CAT), malondialdehyde (...