Suberoylanilide hydroxamic acid (SAHA) causes tumor growth slowdown and triggers autophagy in glioblastoma stem cells (original) (raw)
AI-generated Abstract
The study investigates the effects of Suberoylanilide hydroxamic acid (SAHA) on glioblastoma stem cells (GSCs), which are a major contributor to glioblastoma multiforme's aggressive behavior. Findings reveal that SAHA slows tumor growth and triggers autophagy in GSCs. The treatment leads to the formation of autophagosomes and alters the expression of autophagy-related proteins, suggesting a potential therapeutic avenue targeting GSCs to improve treatment outcomes in GBM.
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