Antioxidant Status, Oxidative Stress and Lipid Profile in Essential Hypertensive Men (original) (raw)

2013, Journal of Evolution of Medical and Dental Sciences

Hypertension is a major health burden and coexists of with imbalance in antioxidants and lipid profile. This study is done to evaluate the total antioxidant status and oxidative stress like Malondialdehyde (MDA), catalase, superoxide dismutase (SOD), uric acid and correlate with lipid profile among hypertensive men. Significant increase in MDA, uric acid and dyslipidemia was found among hypertensive men. Also total antioxidant status and other antioxidants like SOD, catalase was found to be decreased in hypertensive men. Hence it is concluded that lipid peroxidation occur in hypertension which leads to endothelial dysfunction, renal blood flow alteration and tissue damage. As a result of which dyslipidemia, hyperuricemia and decrease in anti oxidants are seen. Hence decrease in antioxidants is a useful marker for antioxidant therapy to prevent organ damage among hypertensive.