Antibacterial activity studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes with Mannich base ligand (original) (raw)
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2017
A new Schiff base (R,E)-2(dimethylamino)-3-(4-hydroxyphenyl) -N,2,3-trimethyl-N’-(1-ptolylethylidene) butanehydrazide, Tmbh and Mn(II), Ni(II), Co(II), Cu(II) and Zn(II) complexes were synthesized and characterized on the basis of analytical, magnetic, cyclic voltammetric, conducto metric, UV-Visible, TG/DTA, IR, NMR, EPR and mass spectral data. Tmbh acts as a uninegative/neutral bidentate ligand in all the complexes bonding through carbonyl oxygen and azomethine nitrogen. Half field signal observed in the ESR spectrum of Ni(II) complex is indicative of its dimeric nature and the trend in g-values suggests tetragonally distorted octahedral geometries for Co(II), Ni(II) and Cu(II) complexes. All the complexes exhibit irreversible redox behavior. Morphology of Tmbh and the complexes have also been investigated through SEM and powder XRD data. Antimicrobial effects of the ligand and the complexes against the microbes Bacillus subtilis, Escherichia coli, Psuedomonas aeruginosa and Klebs...
International Journal of Scientific Research in Science and Technology, 2023
The Present research work describes biological activity of amide group containing ligands and their Mn(II), Ni(II), Co(II) and Cu(II) complexes against E.coli and S.aureus. The standard disc diffusion method has been employed for investigations. The data obtained during study has been correlated for structure activity relationship and a trend has been pointed for a series of complexes.
Chintan Research Journal (ISSN : 2229-7227\), 2024
In present study the complexes of the type MLXn, where M= Cu(II), Co(II), Ni(II), Zn(II) and X= H 2 O/Cl and L is the schiff base ligand prepared from 2,4-dihydroxy-5-Acetylacetophenone and 1,4-diaminobutane have been synthesized, as they are widely used as chelating ligands in coordination chemistry. All complexes isolated in solid, are stable in air and characterized by the elemental analysis, metal content determination, magnetic measurements, thermo gravimetric analysis (TGA), IR, and electronic spectral data. The physicochemical data suggest a pseudo octahedral structure to Cu(II) and an octahedral for Co(II), Ni(II), and Zn(II) complexes. The ligand field parameters have been calculated and related to the electronic environment. The Schiff base and its complexes were screened for their antimicrobial activities against various microorganisms.
Macrocyclic ligands are polydentate ligands containing donor atoms either incorporated or attached to cyclic backbone and showed significance in various biological studies. Tetraaza macrocyclic complexes of transition metals, Ni(II), Cu(II), Fe(III), and Mn(II) were synthesized in methanolic media using template method. These complexes were non-hygroscopic and consist of crystalline solids. Structural identification of these complexes was done using analytical techniques UV-Vis and IR Spectroscopy. The antibacterial activities of macrocyclic complexes (1-6) were screened against both Gram-negative bacteria (Escherichia coli and Vibrio cholerae) and Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus). In the present study we have reported that these synthesized complexes showed slight antibacterial activity except macrocyclic complex (6) which showed moderate antibacterial activity.
Annals of the Romanian Society for Cell Biology, 2021
Three novel trinuclear Ni(II) complexes, [Ni 3 (L 1) 2 (py) 4 ] (1), [Ni 3 (L 2) 2 (H 2 O) 2 (DMA) 2 ] (2) and [Ni 3 (L 3) 2 (py) 4 ] (3), with trianionic pentadentate ligands derived from salicylhydrazide with N-acyl substituents [H 3 L 1 =N 2-crotonoylsalicylhydrazide, H 3 L 2 = N 2-(3,3dimethylacryloyl)salicylhydrazide, H 3 L 3 =N 2-cinnamoylsalicylhydrazide] were synthesized and characterized by elemental analysis, spectroscopic techniques, like UV-Vis, FT-IR and NMR, molar conductivity and magnetic susceptibility measurements, and single crystal X-ray diffraction. The solid state structures of the complexes reveal the binding modes of the different ligands via ONO donor atoms. Complex 1 crystallises in the triclinic system while complexes 2 and 3 crystallise in the monoclinic system with space groups Pī (1) and P2 1 /c (2 and 3). Computational studies were performed using Density Functional Theory (DFT) to obtain physical properties of all three complexes. The ligands and their metal complexes were screened for antibacterial activity to assess their inhibition potential against two Gram positive bacteria; S. aureus and B. subtilis and two Gram negative bacteria; E. coli and P. aeruginosa by the well diffusion method using gentamicin as a positive control. Antibacterial screening data reveals that the trinuclear Ni(II) complexes have significantly enhanced inhibitory activities compared to the ligands.
Iraqi journal of science, 2020
Binuclear metal complexes of the metal ions Fe (II), Co (II), Ni (II) and Cu (II) were synthesized by the reaction of these metal ions with the imine of benzidine (H2L) as a primary ligand and o-phenylenediammine (OPD) as a secondary ligand in a molar ratio of 2:2:1. The prepared complexes were characterized using CHN elemental analysis, FT-IR, UV-visible, molar conductivity, magnetic susceptibility and TGA-DTA thermogravimetric analysis. All the prepared complexes showed apparent stability and could be stored for months without any appreciable change. According to the results obtained by elemental and spectral analyses, a tetrahedral structure is suggested for all the prepared complexes, except for the copper complex which showed a square planar structure. The antimicrobial activities of these complexes were evaluated against Bacillus spp. (Gram-negative bacteria), Proteus spp. (Gram-positive bacteria) and Aspergillus niger (A. niger, a fungal species). The results showed that all...
Bioinorganic Chemistry and Applications, 2012
Two new heterocyclic Schiff bases of 4-amino-5-mercapto-3-H/propyl-1,2,4-triazole and 5-nitrofurfuraldehyde [HL 1-2 ] and their cobalt, nickel, copper, and zinc complexes have been synthesized and characterized by elemental analyses, spectral (UV-Vis, IR, 1 H NMR, Fluorescence, and ESR) studies, thermal techniques, and magnetic moment measurements. The heterocyclic Schiff bases act as bidentate ligands and coordinate with metal ions through nitrogen and sulphur of the thiol group. The low molar conductance values in DMF indicate that the metal complexes are nonelectrolytes. The magnetic moments and electronic spectral data suggest octahedral geometry for the Co(II), Ni(II), and Zn(II) complexes and square planar for Cu(II) complexes. Two Gram-positive bacteria (Staphylococcus aureus MTCC 96 and Bacillus subtilis MTCC 121), two Gram-negative bacteria (Escherichia coli MTCC 1652 and Pseudomonas aeruginosa MTCC 741), and one yeast, Candida albicans, were used for the evaluation of antimicrobial activity of the newly synthesized compounds.
Synthesis, Spectroscopic and Antimicrobial Studies of Co(II), Ni(II), Cu(II) and Zn(II) Complexes
The Schiff base was synthesized by condensation of 2-hydroxy-1-naphthaldehyde with 3aminobenzoic acid in 1:1 molar ratio. The Schiff base ligand formed complexes with Co (II), Ni (II), Cu (II) and Zn (II) acetate via mechanochemical synthesis. The synthesized compounds were characterized by solubility test, thermal analysis, FT-IR, powder x-ray diffraction, molar conductance measurement, magnetic susceptibility and elemental analysis. The Schiff base has a melting point of 190 o C. The decomposition temperature of complexes was found to be in the range 289-302 o C. The Schiff base and its metal (II) complexes were soluble in DMF, DMSO and sparingly soluble in acetonitrile, chloroform, diethyl ether and insoluble in n-hexane which indicate the polar nature of the synthesized compounds. The IR spectral analysis of the free Schiff base shows a band at 1622 cm-1 , assigned to v(C=N) stretching vibrations. This band was shifted in the spectra of complexes (1607-1633 cm-1), indicating coordination of the Schiff base to the metal ion through the azomethine group. The molar conductance of complexes determined are in the range 9.51-14.87 Ohm-1 cm 2 mol-1 which indicate the non-electrolytic nature in DMF. Magnetic susceptibility measurements of Co (II), Ni (II) and Cu (II) complexes exhibit a magnetic moment in the range 1.25-3.08 BM. The values correspond to square-planar geometry. The magnetic moment value of Zn (II) complex indicates a diamagnetic behaviour. The elemental analysis of the complexes for C, H and N determined showed that the observed and the calculated percentages of the elements are in good agreement.
Journal of the Chilean Chemical Society, 2021
A series of transition metal complexes having general formula [M(L1)(L2)](NO3)2, (where, M = Cu(II), Ni(II), and Zn(II)) of mixed ligands, L1 = Isonicotinamido-Thiophene-2-Carbaldimine, L2 = 1, 10-phenanthroline, were synthesized. The obtained compounds were successfully characterized by different spectroscopic techniques. Conductivity measurements indicated that all complexes were 1:2 electrolytes in nature. IR spectra indicated that ligands coordinated to metals via the carbonyl oxygen atom and the azomethine nitrogen atom. Magnetic moment values and UV-Visible spectra confirmed square planar structure around the Cu(II), and Ni(II) ions, and a tetrahedral geometry around the Zn(II) ion.The metal complexes were tested against Escherichia coli and Pseudomonas sp. Among the tested compounds, Zn(II)complex showed higher antibacterial activity over both bacterial strains against reference drug Kanamycin. Moreover, synthesized metal complexes exhibited moderate antioxidant activity than the Schiff base. Cu(II) complexes were found to be most active whereas, Zn(II) complexes showed the lowest antioxidant activity comparable to the BHT.
Bioinorganic Chemistry and Applications, 2006
A series of antibacterial and antifungal amino acid-derived compounds and their cobalt(II), copper(II), nickel(II), and zinc(II) metal complexes have been synthesized and characterized by their elemental analyses, molar conductances, magnetic moments, and IR, and electronic spectral measurements. Ligands (L 1 )-(L 5 ) were derived by condensation of β-diketones with glycine, phenylalanine, valine, and histidine and act as bidentate towards metal ions (cobalt, copper, nickel, and zinc) via the azomethine-N and deprotonated-O of the respective amino acid. The stoichiometric reaction between the metal(II) ion and synthesized ligands in molar ratio of M : L (1 : 1) resulted in the formation of the metal complexes of type [M(L)(H 2 O) 4 ]Cl (where M = Co(II), Cu(II), and Zn(II)) and of M : L (1 : 2) of type [M(L) 2 (H 2 O) 2 ] (where M = Co(II), Cu(II), Ni(II), and Zn ). The magnetic moment data suggested for the complexes to have an octahedral geometry around the central metal atom. The electronic spectral data also supported the same octahedral geometry of the complexes. Elemental analyses and NMR spectral data of the ligands and their metal(II) complexes agree with their proposed structures. The synthesized ligands, along with their metal(II) complexes, were screened for their in vitro antibacterial activity against four Gram-negative (Escherichia coli, Shigella flexeneri, Pseudomonas aeruginosa, and Salmonella typhi) and two Gram-positive (Bacillus subtilis and Staphylococcus aureus) bacterial strains and for in vitro antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani, and Candida glaberata. The results of these studies show the metal(II) complexes to be more antibacterial/antifungal against one or more species as compared to the uncomplexed ligands. The brine shrimp bioassay was also carried out to study their in vitro cytotoxic properties. Five compounds, (3), (7), (10), (11), and (22), displayed potent cytotoxic activity as LD 50 = 8.974 × 10 −4 , 7.022 × 10 −4 , 8.839 × 10 −4 , 7.133 × 10 −4 , and 9.725 × 10 −4 M/mL, respectively, against Artemia salina.