The Relationship Between Severity of Kawasaki Disease and History of Ischemic Heart Disease in the Parents (original) (raw)
Related papers
Kawasaki Syndrome and Risk Factors for Coronary Artery Abnormalities
The Pediatric Infectious Disease Journal, 2006
Background: Kawasaki syndrome (KS) causes significant morbid ity among children in the United States and other countries and can result in a range of cardiac and noncardiac complications. Methods: To describe the occurrence of KS in the United States and risk factors for the development of coronary artery abnormalities (CAA), national KS surveillance data were analyzed for patients with KS onset during 1994-2003. The surveillance is a passive system, and information is collected on a standardized case report form. Results: During 1994 through 2003, 3115 patients who met the KS case definition were reported to the national KS surveillance system. The median age of KS patients was 32 months; the male-female ratio was 1.5:1. Nearly one-third (31.8%) of the cumulative number of KS cases occurred during January through March. During the study period, 362 (12.9%) of 2798 KS patients had CAA. The proportion of patients with CAA increased from 10.0% in 1994 to 17.8% in 2003. Age younger than 1 year and 9-17 years, male sex, Asian and Pacific Islander race and Hispanic ethnicity (a previously unidentified risk factor) were significantly associated with the development of CAA. Conclusions: The increase in CAA was attributed to widespread use of the criteria of de Zorzi et al, resulting in increased recognition of coronary artery dilatations. The factors contributing to a higher risk of CAA, such as delayed treatment, particularly among Hispanics, need to be investigated.
Clinical Laboratory, 2021
Background: Patients with Kawasaki disease (KD) may develop cardiovascular complications in the presence of predictive factors, including young age < 6 months, male gender, unfavorable response to intravenous immunoglobulin (IVIG), low albuminemia, thrombocytosis, fever over 8 days, increased C-reactive protein (CRP), elevated levels of 25 OH vitamin D3, elevated levels of fibroblast growth factor 23 (FGF23), elevated D-dimers, elevated ferritin. The objectives of this study were to determine the laboratory negative predictive factors for the occurrence of cardiac complications in children with KD. Studies in the literature that dealt with these predictive factors were analyzed. Methods: We followed the studies published in PubMed over a 10-year period. Seventy articles were reviewed and, after applying the inclusion and exclusion criteria, 20 articles were selected. Results: We evaluated the population studies which showed factors can predict the occurrence of heart complications. These factors were different depending on age and depending on resistance to IVIG treatment. Conclusions: Some biological parameters such as low albumin, thrombocytosis, increased CRP, elevated levels of 25 OH vitamin D3, elevated levels of FGF23, elevated D-dimers, and elevated ferritin could be considered as laboratory negative predictive factors for CAL.
Cardiac involvement in Kawasaki disease in Pakistani children
Annals of Pediatric Cardiology, 2012
Kawasaki disease is an acute, self-limiting disease of unknown etiology. [1] It is characterized by vasculitis involving small and medium-sized vessels of various organs with striking predilection for the coronary arteries. [2,3] It was first described in Japan by Tomisaku Kawasaki. [4] It is now known to occur all around the world and in children of all races. [1] It is the leading cause of acquired heart disease in Japan, Europe and the USA. [5] Average annual attack rate in Japan in 1997-1998 was 112 per 100,000 cases for children under 5 years of age. [6] The annual attack rate in USA is higher in Asians compared with non-Asians. [7] Although Kawasaki disease is not unknown in the Indian subcontinent. [8-10] and Pakistan, no study has been published from Pakistan. We conducted this study to evaluate the clinical features at presentation and pattern of cardiac involvement in Pakistani children with Kawasaki disease.
Cardiovascular risk factors after Kawasaki disease: A case-control study
The Journal of Pediatrics, 2001
in brachial arteries. 8-10 Abnormal endothelial function may be a very early precursor in the atherosclerotic process. 11-14 The interaction of cardiovascular risk factors is well known both in adult and pediatric populations 15-17 but has not been optimally defined in patients with Kawasaki disease. We sought to determine the cardiovascular risk profiles of patients who have had Kawasaki disease and to relate them to noninvasive measures of endothelial function. METHODS This study was a case-control study. Cases were identified from a Kawasaki disease database of the Division of Cardiology. All patients who had typical Kawasaki disease with at least 5 of 6 diagnostic criteria and who received the diagnosis at least 5 years before the onset of the study were eligible. Preference for enrollment was given to patients living within reasonable proximity of the study institution, and subjects were chosen at random from a stratified list based on degree of original and persistent coronary artery involvement. The control group included normal nonsmoking volunteer adolescents of similar age. All participants gave appropriate informed consent as approved by the institution's Research Ethics Board. The medical records and echocardiograms were reviewed for all of the cases. Both the case and control groups There has been ongoing concern that patients both with and without significant coronary artery involvement after Kawasaki disease may be more prone to have atherosclerotic cardiovascular
IOSR Journals , 2019
The characteristics of Kawasaki disease have significantly changed in pediatric age group during last few decades. The present study was conducted to study the clinical profile and outcome and risk factors of Kawasaki disease in children in the largest children hospital of Bangladesh.This observational prospectivestudy was conducted in cardiology wardwith a diagnosis of Kawasaki disease from April 2014 to March 2019. Forty three (43) children aged between 3 months to 10 years were studied.Kawasaki disease is more prevalent among male child (72%). Most commonly encountered risk factor for cardiovascular involvement especially coronary dilatation or aneurysmal change is more observed in younger age of presentation. Fever, rash, conjunctivitis, erythema and edema of limbs, periungual skin desquamations are the presenting features. Cardiovascular involvement of left main coronary artery dilation is the most frequently observed aneurismal change observed among study population which was evident in 68% of the children having coronary involvement. All the study patient received high dose aspirin (100%) and 93% received IVIG of whom 6.9% had IVIG-resistant Kawasaki disease. Commonly occurring complication is uveitis (16.28%). Among the total 43 study population 1 patient expired(2.3%).Clinicians should have a high index of suspicion of Kawasaki disease in persistently febrile patients and once clinically diagnosed, echocardiography should be done and IVIG therapy along with aspirin should be started, specially in infants (<6 months) as they have the higher tendency to develop coronary aneurysm.
The Turkish journal of pediatrics
The aim of this study was to identify the risk factors for persistence of coronary artery abnormalities (CAAs) in Kawasaki disease and to compare the differences between complete (n=25) and incomplete (n=18) forms of the disease in relation to CAAs. The patients' demographic (age and sex), clinical (season of admission, duration of fever, form of Kawasaki disease), laboratory (complete blood count, eosinophil count, serum biochemistry, C-reactive protein level, erythrocyte sedimentation rate [ESR], urinary analysis), echocardiographic and therapeutic data were evaluated retrospectively from the medical records. The incidence of sterile pyuria was nearly twofold greater in patients with initial CAAs than in patients in which CAAs were not present (25% and 13%, respectively; p=0.33). In multivariate logistic regression analysis, ESR and pyuria were found to be associated with persistence of CAAs (p=0.035 and p=0.046, respectively). In addition, we found that duration of fever was ...
Medical Sciences, 2019
The present study was performed to evaluate the clinical symptoms and cardiovascular complications in patients with typical and atypical Kawasaki disease (KD). This retrospective study was conducted on the medical records of 176 patients with KD for three years. The study population was divided into two groups of typical and atypical based on the KD clinical criteria. The two groups were compared in terms of demographic data, clinical symptoms, cardiac lesions, and laboratory markers. Based on the diagnostic criteria, 105 (60%) and 71 (40%) patients were diagnosed with typical and atypical KD, respectively. The mean age of the typical patients (38.16 months) was higher than that of the atypical group (24.03 months) at the time of diagnosis (p < 0.05). The results revealed no significant difference between the two groups regarding the seasonal distribution of KD onset (p = 0.422). However, the most common season for the diagnosis of the disease was spring, followed by winter. Ther...