Comparative Studies on Clinical Isolates of Hypervirulent and Classical Klebsiella pneumoniae (original) (raw)

Research Journal of Pharmacy and Technology

Abstract

Hypervirulent Klebsiella pneumonia (hvKP), typically linked with the hypermucoviscous phenotype, has evolved as a clinically significant pathogen responsible for catastrophic disseminated infections including osteomyelitis, pyogenic liver abscesses (PLA), and endophthalmitis in an otherwise younger and healthier population. Methods: Mansoura University Hospitals, Egypt have utilised VITEK® 2 to identify clinical K. pneumoniae isolates. The Kirby Bauer's disc diffusion method was employed to asses sensitivity to antimicrobial. String test for detecting microvasculitis, Serotyping, and Bio-typing are among the phenotypic methods employed. Polymerase chain reaction (PCR) was performed to amplify capsular serotype-specific genes (K1 and K2) as well as virulence-associated genes (rmpA and magA). Results: Over two-years, 100 hypermucoviscous phenotype K. pneumoniae and 100 classical K. pneumoniae strains were isolated and screened by string test. Hypermucoviscosity Serotyping revealed...

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