Chemical Composition and Some Biological Activities of Artemisia marschalliana Essential Oil (original) (raw)
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Jundishapur Journal of Natural Pharmaceutical Products, 2022
Background: Malaria is one of the most momentous transmittable diseases globally. Medicinal herbs like Artemisia species might be possible sources of new, effective, and cheap antiplasmodial products, making up the leading molecules to investigate new antimalarial drugs. The Artemisia genus, which belongs to the Asteraceae family, is a widely distributed medicinal plant in Iran. Methods: In this study, the antimalarial activities of essential oil, different extracts, and vacuum liquid chromatography (VLC) fractions of A. fragrans Willd. were examined by a cell-free β-hematin formation assay. The aerial parts of A. fragrans were extracted by a Soxhlet extractor, and essential oil was obtained by a Clevenger apparatus. Then, GC-MS analysis was used to identify volatile compounds of essential oil and the 100% VLC fraction of chloroform. Results: Among the extracts, chloroform extract illustrated considerable antimalarial activity compared to the control (P < 0.001), with the IC50 va...
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Malaria Journal, 2011
Natural compounds, mostly from plants, have been the mainstay of traditional medicine for thousands of years. They have also been the source of lead compounds for modern medicine, but the extent of mining of natural compounds for such leads decreased during the second half of the 20th century. The advantage of natural compounds for the development of drugs derives from their innate affinity for biological receptors. Natural compounds have provided the best anti-malarials known to date. Recent surveys have identified many extracts of various organisms (mostly plants) as having antiplasmodial activity. Huge libraries of fractionated natural compounds have been screened with impressive hit rates. Importantly, many cases are known where the crude biological extract is more efficient pharmacologically than the most active purified compound from this extract. This could be due to synergism with other compounds present in the extract, that as such have no pharmacological activity. Indeed, such compounds are best screened by cell-based assay where all potential targets in the cell are probed and possible synergies identified. Traditional medicine uses crude extracts. These have often been shown to provide many concoctions that deal better with the overall disease condition than with the causative agent itself. Traditional medicines are used by ~80 % of Africans as a first response to ailment. Many of the traditional medicines have demonstrable anti-plasmodial activities. It is suggested that rigorous evaluation of traditional medicines involving controlled clinical trials in parallel with agronomical development for more reproducible levels of active compounds could improve the availability of drugs at an acceptable cost and a source of income in malaria endemic countries.
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Malaria is still a health problem in the world, with 229 million cases of malaria worldwide and more than 400,000 people suffering from malaria dying each year.1 The high number of malaria cases is caused by the emergence of various obstacles in eradicating malaria, including the resistance of malaria parasites to available antimalarial drugs, increased Anopheles mosquito immunity to chemicals, and the discovery of side effects from these antimalarial drugs.2 The growing and widespread resistance to all the first-line antimalarial drugs used in the treatment and prevention of malaria has now caused many problems in the malaria prevention programme.3 Research to obtain new antimalarial drugs, both synthetic drugs and those derived from natural materials, is continuing, one of which is through the exploration of active compounds from natural materials, especially medicinal plants that have traditionally been used by the community to treat malaria in various endemic areas across the wo...
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Assessment of in vivo antimalarial activities of some selected medicinal plants from Turkey
Resistant infections lead to increased necessity of searching novel drugs and drug combinations. The purpose of this paper was to investigate antimalarial properties of some selected medicinal plants that have been traditionally used in Turkey for antipyretic and analgesic purposes. Lavandula stoecheas subsp. cariensis , Phlomis nissolii , Phlomis bourgaei, Phlomis leucophracta, Centaurea hierapolitana, Centaurea polyclada , Centaurea lydia , Scrophularia cryptophila, Scrophularia depauperata, Scrophularia floribunda, Rubia davisiana, and Alkanna tinctoria subsp. subleiocarpa were investigated for their in vivo antimalarial activities in mice infected with Plasmodium yoelii. Two hundred fifty to 500 mg/kg doses of plant extracts were given to mice as a single daily dose for 4 days. P. nissolii water extract, C. lydia chloroform extract, S. cryptophila ethanol extract, and C. polyclada methanol extract showed antimalarial activity with reducing parasitaemia. The chemotherapeutic effects of plant extracts ranged between 13.5 % and 66.91 %. The chemosuppressions exerted by combined plant extracts of P. nissolii , S. cryptophila , and C. lydia with C. polyclada methanol extract were detected as 51.25 %, 57.33 %, and 58.33 %, respectively. Investigation of cytotoxic activities against brine shrimps revealed that methanol extract of C. polycada, chloroform extract of C. lydia, and ethanol extract of S. cryptophila showed cytotoxic activities, while water extract of P. nissolii was not active against brine shrimps.