Chemical constituents of Kigelia pinnata twigs and their GLUT4 translocation modulatory effect in skeletal muscle cells (original) (raw)
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ANTI-HYPERGLYCEMIC AND IN-VITRO ANTIOXIDANT EFFECT OF KIGELIA PINNATA FRUIT
Diabetes mellitus (DM) is a complex metabolic disease characterized by chronic hyperglycaemia commonly associated with oxidative stress. The present study aims at evaluating the antioxidant and anti-hyperglycemic potential of various concentrations of hydroalcoholic extract of Kigelia pinnata fruit. The in-vitro antioxidant activity was assessed using 1,1-Diphenyl-2-picrilhydrazyl (DPPH), nitrDiabetes mellitus (DM) is a complex metabolic disease characterized by chronic hyperglycaemia commonly associated with oxidative stress. The present study aims at evaluating the antioxidant and anti-hyperglycemic potential of various concentrations of hydroalcoholic extract of Kigelia pinnata fruit. The in-vitro antioxidant activity was assessed using 1,1-Diphenyl-2-picrilhydrazyl (DPPH), nitric oxide, hydroxyl ion and hydrogen peroxide for free radical scavenging properties of the extracts, and determining their phenol and flavanoid contents. The antidiabetic activity was tested in rats following streptozocin induced hyperglycemia. The in-vitro antioxidant activity using DPPH, nitric oxide radical, hydroxyl radical and H2O2 radical showed IC50 value 77.49±0.38, 91.07±0.62, 118.91±0.43 and 86.46±0.52 ?g/ml respectively. The hydroalcoholic extract of the fruits with dose 250, 500 and 750 mg/Kg exhibited anti-hyperglycemic activities with 37.08%, 55.08% and 56.19% reduction, respectively. These findings suggest that K. pinnata fruits possess slight antidiabetic and good antioxidant properties, and therefore could be used as starting point for the development of herbal medicines and/or source of new drug molecules against oxidative stress or it associated disorders.ic oxide, hydroxyl ion and hydrogen peroxide for free radical scavenging properties of the extracts, and determining their phenol and flavanoid contents. The antidiabetic activity was tested in rats following streptozocin induced hyperglycemia. The in-vitro antioxidant activity using DPPH, nitric oxide radical, hydroxyl radical and H2O2 radical showed IC50 value 77.49±0.38, 91.07±0.62, 118.91±0.43 and 86.46±0.52 ?g/ml respectively. The hydroalcoholic extract of the fruits with dose 250, 500 and 750 mg/Kg exhibited anti-hyperglycemic activities with 37.08%, 55.08% and 56.19% reduction, respectively. These findings suggest that K. pinnata fruits possess slight antidiabetic and good antioxidant properties, and therefore could be used as starting point for the development of herbal medicines and/or source of new drug molecules against oxidative stress or it associated disorders.
Pharmacognostic Study of Leaves of Kigelia pinnata (Lam) Benth
Journal of Drug Delivery and Therapeutics, 2019
The Kigelia pinnata (Lam) Benth is a species of the Bignoniaceae family commonly known as Kigelia africana is locally known as waghul phul. The adult sausage tree has spectabular fruits these can weigh several kilogram hence the tree English common name worsboom. Wherever the trees grows it is usually evergreen especially places where rainfall occurs throughout the year but deciduous in places of long dry season. Kigelia pinnata is renowned for its traditional application as anti-inflammatory, anti-diabetic, anti-oxidant, anti –microbial, and anti-cancer effects. It contains chemical constituent like kigenol, kigelinone7, kigenol12, iso-kigenolls. In the present work pharmacognostic studies are carried out to investigate its medicinal properties. The study consists of macroscopic character of the plant Kigelia pinnata physico-chemical parameters like total ash, acid insoluble ash, thin layer chromatography etc. Keywords- Kigelia pinnata, pharmacognostic studies, total ash, ...
2017
The study was designed to evaluate the phytochemical profile, antioxidant and cytotoxic activity of a methanolic extract from the stem bark of Kigelia pinnata (MEKP). The In-vitro anti-oxidative activity was investigated using DPPH assay, superoxide scavenging assay and cytotoxic activity was studied using cell viability (MTT) assay on non small lung cancer cell-line (A-549). MEKP displayed prominent anti-oxidative and cytotoxic activity against A549 cells. On the basis of the In-vitro studies it could be concluded that there is huge scope for future investigation on K. pinnata as a source of potential anti cancer drug.
In Vivo Hypoglycemic Effect of Kigelia africana (Lam): Studies With Alloxan-Induced Diabetic Mice
Journal of Evidence-Based Integrative Medicine
The claims by the traditional herbal medicine practitioners that Kigelia africana has bioactivity against several diseases, including diabetes mellitus, were investigated in this study. Type I diabetes mellitus was induced in mice by intraperitoneal administration of alloxan monohydrate followed by treatment with the therapeutic doses of the aqueous and ethyl acetate leaf extract of K africana to the experimentally diabetic mice. The treatment effects were compared with the normal control, diabetic control, and diabetic control rats treated with a standard antidiabetic drugs (insulin administered intraperitoneally at 1 IU/kg body weight in 0.1 mL physiological saline or glibenclamide administered orally at 3 mg/kg body weight in 0.1 mL physiological saline). Phytochemical composition of the leaf extract was assessed using standard procedures and mineral elements assessed using atomic absorption spectrophotometry and total reflection X-ray fluorescence system. Oral and intraperitonea...
Asian Journal of Pharmaceutical Research and Development
Glucose transporter’s mechanism is influenced by the presence of insulin, especially GLUT4 which acts on muscle, adipose, and brain tissue. Medicinal plants with active compounds that were able to regulate the expression and translocation of GLUT helps in the treatment of insulin resistance and hyperglycemia. This study aimed to determine which active compounds isolated from medicinal plants have antihyperglycemic activity on GLUT4 expression in muscle and adipose tissue. The research method used was by searching the literature electronically with the keywords "Plant Isolation", "Chemical Compounds", "Antihyperglycemic Activity", and "Glucose transporter (GLUT) 4". Literature sources in the form of international and national journals have been found on several sites, such as NCBI, Elsevier and Pubmed, and others. A literature search in the form of selected journals from 2016 to 2021. The data were analyzed using the PRISMA (Prefered Reporting ...