Study of Clinico-Demographic Parameters and Dyslipidemia among Non-Diabetic Coronary Artery Disease Patients (original) (raw)
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Assessment of cardio-vascular disease risk in diabetic population of Northern India
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Asian Journal of Medical Sciences, 2013
Background: Dyslipidemia, one of the classical Framingham risk factors of cardiovascular diseases, accounts significantly to the rise of non communicable diseases in India. Urbanization, along with greater consumption of dietary fats and decreased physical activity, has led to an increase in this problem manifold. Objectives: To determine the prevalence of dyslipidemia among urban adults of Siliguri city, West Bengal and to identify the cardio-vascular risk factors associated with it. Methods: This descriptive, cross-sectional study was carried out among the 226 adults aged ≥20yrs in an urban area of Siliguri city, West Bengal, India. Data was collected by detailed history and physical examination; biochemical measurements were done using standards procedures. Dyslipidemia was defined by the presence of one or more than one abnormal serum lipid concentration. Statistical analysis was done using chi-square test, t test and logistic regression analysis using SPSS 20 software (Chicago,...
Journal of the American College of Cardiology, 2001
The aim of this study was to assess the prevalence and risk factors for coronary artery disease (CAD) in a native urban South Indian population. BACKGROUND High prevalence rates of premature CAD have been reported in migrant Asian Indians. There are very few studies on CAD in native Indians living in the Indian subcontinent. METHODS The Chennai Urban Population Study (CUPS) is an epidemiological study involving two residential areas in Chennai in South India. Of the total of 1,399 eligible subjects (age Ն20 years), 1,262 (90.2%) participated in the study. All the study subjects underwent a glucose tolerance test and were categorized as having normal glucose tolerance (NGT), impaired glucose tolerance (IGT) or diabetes. Twelve-lead electrocardiogram (ECG) was performed in 1,175 individuals (84%). Coronary artery disease was diagnosed based on previous medical history or Minnesota coding of ECGs. RESULTS The overall prevalence rate of CAD is 11.0% (age standardized, 9.0%). The prevalence rates of CAD were 9.1%, 14.9% and 21.4% in those with NGT, IGT and diabetes, respectively. Prevalence of CAD increased with an increase in total cholesterol (trend chi-square: 26.2, p Ͻ 0.001), low-density lipoprotein (LDL) cholesterol (trend chi-square: 24.5, p Ͻ 0.001), triglycerides (trend chi-square: 9.96, p ϭ 0.002) and total cholesterol/high-density lipoprotein ratio (trend chi-square: 6.14, p ϭ 0.0132). Multiple logistic regression analysis identified age (odds ratio [OR]: 1.05, p Ͻ 0.001) and LDL cholesterol (OR: 1.009, p ϭ 0.051) as the risk factors for CAD. CONCLUSIONS The prevalence of CAD is rising rapidly in urban India. Lifestyle changes and aggressive control of risk factors are urgently needed to reverse this trend.
2016
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Study of the pattern of dyslipidemia in urban population of central Madhya Pradesh
IP innovative publication pvt. ltd, 2019
Introduction: Increase in the levels of cholesterol, triglycerides and LDL cholesterol (LDL-C) and low HDL Cholesterol (HDL-C) is known to be a risk factor for coronary artery disease (CAD) and myocardial ischaemia. Studies have shown that dyslipidemia in Indians show a unique pattern of low HDL-C, high triglycerides, and high LDL-C but such studies are few and far between. The present study was undertaken in our diagnostic centre with the aim of determining the trends in the lipid values of urban population of Indore and also to determine the gender differences in the cholesterol, HDL-C, LDL-C, Triglycerides values in the study population. Materials and Methods: This study was carried out on a total of 5857 patients of all ages and both sexes registered in our diagnostic centre for lipid profile test on 22,23 and 24 November 2019. Dyslipidemia was defined as per the National cholesterol education programme (NCEP) and ATPIII criteria. Statistical analysis was performed on all lipid parameters and expressed as mean ± SD and median. Results: The mean age of females was 49±12.7 years and males was 51±13.9 years with a male to female ratio of 1.34:1. The mean cholesterol value was 167.7±35.8 mg/dl and was highest in 41-50 years age group with a mean of 172.7±34.7 mg/dl.The mean triglycerides value was 140.1±79.8 mg/dl and was highest in 41-50 years of age group. The mean HDL-C was 40.5±9.7 mg/dl. Mean LDL-C was 99.3±29.5 mg/dl. The risk ratio > 4.5 was observed in 2290(39%) patients out of which 1596(47.47%) were males and 694(27.82%) were females Conclusion: Dyslipidemia is a major risk factor for coronary artery disease and stroke and there is an alarming increase in the incidence of CAD in younger age groups. Large scale, cross sectional, population based Studies on the pattern of dyslipidemia are needed to frame a health care policy which would be more preventive and predictive in future
Indian Journal of Endocrinology and Metabolism, 2014
Introduction: Dyslipidemia is a primary, widely established as an independent major risk factor for coronary artery disease (CAD). Asians differs in prevalence of various lipid abnormalities than non-Asians. Hence, this study was conducted with objective to evaluate the lipid abnormalities and there correlation with traditional and non-traditional risk factors in known subjects with CAD. Materials and Methods: We studied the pattern and association of dyslipidemia with cardiovascular risk factors in 300 (Male: 216; Female: 84, age: 60.9 ± 12.4 years, range: 25-92 years) angiographically proved CAD patients. All patients were evaluated for anthropometry and cardiovascular risk factors and blood samples were collected for biochemical and infl ammatory markers. Results: Hypercholesterolemia, hypertriglyceridemia and low high density lipoprotein (HDL) was present in 23.3%, 63.0% and 54.6% in the total study population respectively. A total of 41.3% had atherogenic dyslipidemia (raised triglycerides [TG] and low HDL). Percentage of patients with type-2 diabetes mellitus and hypertension were higher in subjects with atherogenic dyslipidemia. Insulin sensitivity was low; insulin and insulin resistance (IR) along with infl ammatory markers were high in subjects with atherogenic dyslipidemia. Patients with atherogenic dyslipidemia had signifi cantly lower serum vitamin B12 levels and higher homocysteine (Hcy) levels. Hypertriglyceridemia was positively correlated with insulin, homeostasis model assessment of IR, Hcy, interleukin-6, Tumor necrosis factor-alpha, highly sensitive C-reactive protein and negatively with vitamin B12 and quantitative insulin check index and an opposite correlation of all quoted parameters was observed with low HDL. The correlation of traditional and non-traditional risk factors was stronger with low HDL and high TG compared with hypercholesterolemia. Conclusions: Hypertriglyceridemia and low HDL cholesterol is common in patients with CAD compared with hypercholesterolemia. This suggests that different preventive strategy is required in Indian patients with CAD.
Annals of King Edward Medical University, 2010
Coronary artery disease (CAD) is very common in the South Asian sub-continent, yet there is relatively little published rese-arch available from these countries. Although we have a very active Cardiology Department in Mayo Hospital, Lahore, there is a parallel need for documentation of the data generated and its analysis for research and publication. This study was carried out to gain an insight into the nature of the risk factors and presentation of CAD in patients coming to our setup. Objectives: The objective was to study the relation of CAD with anthropometric (BMI, waist circumference, waist – to – height ratio) and demographical (age and gender) factors. Methodology: This study was carried out in the Department of Cardiology, Mayo Hospital, Lahore, for a duration of 17 months. We collected the required information (such as name, gender, and family history, demographical data and anthro-pometric measurements) on a prescribed proforma, managed and then analyzed accordingly. Resu...
Sumathi Publications, 2021
Background: India is witnessing a rising prevalence of non-communicable diseases like diabetes, hypertension, coronary artery disease. This is attributed to rapid nutrition and lifestyle transition taking place since last 2 decades. Obesity is a well-known independent risk factor but very little information is available about role of leanness (low BMI). We investigated whether non-obesity could be an independent risk factor for Coronary artery disease in a rural clinic in KONKAN. Methods: In a cross-sectional study we studied body composition of 300 patients (207 men) who underwent Coronary angiography in a rural hospital in KONKAN region. History of diabetes, hypertension and history of smoking, tobacco chewing was recorded. Body composition was estimated using bio-impedance analyser. Based on results of coronary angiography, we generated a SYNTAX score derived by number of vessels involved and classified them into groups of severity of coronary artery disease (CAD). Results: There were 95 (31 %) diabetes and 189 (63%) hypertensive patients in the sample and 60% of them smoked or chewed tobacco. There were 43 (28 males) patients with SYNTAX score of zero. Among those with coronary artery disease (n=257) increasing severity of CAD was associated with lower body weight, BMI, body fat percentage, and body fat mass and ejection fraction as against positive trend for lean mass and visceral fat. Conclusion: BMI, fat mass decreased with severity of CAD while lean mass and visceral fat increased. We observed high proportion of CAD in underweight and lean KONKAN adults. These findings need further investigations.
Asian journal of pharmaceutical and clinical research, 2022
Objective: The present study was conducted with an objective to study prevalence and pattern of dyslipidemia in newly diagnosed type 2 diabetes mellitus patients. Methods: From August 2021 to March 2022, 161 participants participated in the trial. After a night of fasting, skilled medical laboratory technicians drew 5 ml of blood from each study subject and performed anthropometric measurements on them. Results: 110 patients, or 68.9% of the entire group, had dyslipidemia. About 3.7% (n=6) of the individuals had atherogenic dyslipidemia. Among 2.5% and 23.6% of the participants, high TC (total cholesterol) and low HDL (high-density lipoprotein), respectively, were found to be isolated dyslipidemias. Significantly more hypertensives (77.9%), people with abnormal fasting glucose levels (80.2%), those with elevated postprandial glucose levels (78.8%), and people with larger waist circumference had dyslipidemia (76.0%). Conclusion: Our study showed that diabetic patients have a significant prevalence of dyslipidemia. The main public health issue in underdeveloped nations is dyslipidemia, which also serves as a standalone risk factor for developing cardiovascular disease (CVD). In addition, it complicates the progression of CVD in diabetic individuals and raises mortality when combined with other risk factors like high blood pressure.
Endocrinology&Metabolism International Journal, 2017
Background: Diabetes Mellitus is one of the major endocrinological problem in Nepal and one of the major secondary causes of dyslipidemia, particularly in patients with Type 2 DM with poor glycemic control. This in turn is a major risk factor for atherosclerosis and coronary heart disease. A different pattern of dyslipidemia is present in the diabetic population. Objective: To study the prevalence and pattern of dyslipidemia in type 2 diabetes. Method: The study was conducted among 150 newly diagnosed patients with Type-2 Diabetes mellitus in dhulikhel hospital in between July 2014 to December 2014 who were not taking any lipid loweing drug. Patients were analysed on the basis of parameters like level of total cholesterol (TCHOL), triacylgycerol (TAG), low density lipoprotein (LDL), high density lipoprotein (HDL) and Glycosylated haemoglobin (HbA1c). Result: Total of 150 Type-2 DM patients were studied of which 84 were male and 64 female. The prevalence of dyslipidemia among Type-2 DM patients in our study was 85.33%. Prevalence in male was 85.71% and in female was 84.85%. Among males with dyslipidemia, the proportion of patients with mixed dyslipidemia combined two parameter dyslipidemia and isolated single parameter dyslipidemia were 8.33%, 14.28%, 27.38% respectively while in female it was 19.70%, 24.24%, 30.30% respectively. Conclusion: Majority of patients with Type-2 DM had dyslipidemia. The most common pattern of dyslipidemia among both males and females was isolated dyslipidemia with low HDL.