124 Prevention of Hypoxic-Ischemic Cerebral Damage in Preterm Infants by Phenobarbital (original) (raw)

This study investigates the effectiveness of phenobarbital (PB) in preventing hypoxic-ischemic cerebral damage in preterm infants. A total of 96 preterm infants were enrolled, with some receiving phenobarbital while others were placed in a control group. Results showed a significant reduction in the incidence of early intraventricular hemorrhage (IVH) among phenobarbital-treated infants compared to controls, though rates of severe IVH were similar across groups. The findings suggest that while phenobarbital may play a role in reducing IVH incidence, further research is required to fully understand its impact on neurodevelopmental outcomes in this vulnerable population.