Temporal trends of semen quality among male partners of infertile Greek couples undergoing oocyte donation cycles: a retrospective study in a single IVF center (original) (raw)
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Setting Standards of Male Fertility I. Semen Analyses in 1500 Patients - A Report
Andrologia, 2009
Standard-Werte der Fertilität des Mannes I. Samenanalysen von 1500 MännernDie Samenproben von 1500 Männern, bei denen eine Vasektomie bevorstand, wurden eingehend untersucht. Die Ergebnisse wurden mit den Berichten anderer Autoren verglichen. Von jedem Mann wurden zwei Ejakulate innerhalb eines Intervalls von 15 Tagen bei einer sexuellen Abstinenz von 3–5 Tagen geprüft. In 13,8% fand sich eine Spermatozoen-dichte unter 20 Mill. Sp./ml und in 21,2% über 100 Mill. Sp./ml. Für Fruktose und Zitronensäure ergab sich jeweils ein höherer Wert bei höherer Spermatozoendichte. Es wird ausdrücklich betont, daß unabhängig von diesen im Kollektiv erhobenen Werten, die im allgemeinen niedrigere Werte als früher postuliert zur Grundlage einer Fertilität beim Manne machen, jeder Einzelfall genau beurteilt werden muß.
Annals of Pathology and Laboratory Medicine, 2017
Background: Infertility is both a clinical and a public problem. Standard semen analysis is the surrogate measure of male fertility in clinical practice to determine prevalence of low sperm count including oligozoospermia and azoospermia and to assess the pattern and distribution of abnormal semen parameters in infertile men. Methods: The retrospective study was conducted with compiling of the data from archival record over a period of three years from June 2013 to June 2016. A total of 933 male partners of women attending the fertility clinic of hospital between the ages of 20 and 50 years were recruited. The samples taken were primary infertility cases using simple random sampling technique. Semen analysis was performed according to the standards outlined by the World Health Organization (5th edition 2010). Parameters outlined included: Appearance, Volume, pH, Sperm concentration, Motility, Morphology, Viability and White cell count. Result: Out of 933 samples, normozoospermia was observed in 659 (70.6%) males, oligozoospermia 170 (18.2%), and azoospermia 104 (11.1%). The azoospermic and oligozoospermic samples had low ejaculated volume, but significantly higher percentage of pus cells in comparison to normozoospermic samples. The oligozoospermic samples had higher percentage of immotile sperms and abnormal morphology in comparison to normozoospermic samples. Asthenozoospermia was observed in 118 (14.2%), teratozoospermia in 24 (2.9%), and oligoteratozoospermia in 11 (1.3%) of samples. Conclusion: Majority of cases of infertility in males show normal sperm count. Oligozoospermia followed by azoospermia is seen in rest of the cases while less sperm motility or less amount of semen are also responsible in some cases.
International Journal of Aging Research, 2020
According to the World Health Organization, about 8 to 10% of couples worldwide have infertility problems and male internal aspects are the main reasons for half of occurrences of human sterility. Through the spermogram, it is possible to qualitatively and quantitatively analyze semen, contributing to the diagnosis of male fertile state. Objective: To study the relationship among sperm viscosity, concentration, motility and volume parameters and male infertility factors and to show the influence of the subject age on these seminal parameters. Methodology: A survey was conducted in the male infertility database of the Nascer Clinic (Recife / Pernambuco) of men aged 27 to 61 years, with a history of marital infertility, from 2018 to 2019. The subjects studied were grouped into categories according to the classification of the seminal parameters analyzed (volume, concentration, motility and viscosity) in their sperm. Student's t-test was used for normal distribution and Mann-Whitney test for non-normal using the GraphPad Prism 8 program. Results: Among the studied individuals, there was a significant difference (p <0.05) between the populations with obstructive azoospermia and nonobstructive azoospermia and among the percentages of oligozoospermic individuals with obstructive azoospermia. The azoospermia group had a significantly higher average age than the normozoospermia group. Conclusions: This suggests that azoospermia is present in older men, compromising male fertility. Sperm testing should be performed by all men of childbearing age to investigate possible changes in the genesis of gametic cells.
Semen Analysis of Total Motile Sperm Count Based on the 1999 and 2010 WHO Criteria
JBRA assisted reproduction, 2021
OBJECTIVE Approximately 15% of the couples suffer from infertility. Half of the cases of infertility are due to male factors. Several sperm function tests have been proposed to evaluate male fertility, but sperm analysis is still the first and most important diagnostic test for male infertility. The prognostic value of semen characteristics such as concentration, morphology and motility markers are often confused with male infertility. Evaluation of seminal parameters and classification for normality remains a frequent topic of discussion. METHODS This study evaluated 477 semen samples from men undergoing investigation or infertility treatment between 2011 and 2015. RESULTS The spermograms of 401 patients were deemed abnormal based on the 1999 World Health Organization (WHO) criteria; the number changed to 223 when the spermograms were assessed based on the 2010 WHO criteria and to 200 when Total Motile Sperm Count (TMSC) was used as the criterion. Sperm morphology was the item in t...
Human Reproduction, 2001
The aim of the study was to determine the semen parameters of a proven fertile population and to compare these parameters with that of a subfertile group in the same region. Sixty-nine fertile male patients were studied and compared with 93 patients recruited at an infertility clinic. A sub-sample of patients was matched according to age. Sixty-one were studied in the fertile group and 62 in the infertile group. Receiver operator characteristics analysis was done on the sub-sample. The threshold value of the progressive motility was 42% and it was the best parameter with sperm morphology to distinguish between the two groups. At 69% sensitivity and 67% specificity the sperm morphology threshold was 12% normal forms. If the positive and negative predictive value was used to screen the general population to identify the subfertile group, a 5% normal morphology threshold was indicated with 14% progressive motility, 30% motility and a concentration of 9⍥10 6 /ml or lower. The negative predictive values of the parameters were good and achieved 90% in most cases. The sensitivity of the semen parameters at the reported thresholds was poor and indicated a large overlap in the distributions of these variables in the fertile and infertile groups. To distinguish between the fertile and subfertile population, the most significant finding of this study was the progressive motility with a threshold level of 14%. The cut-off value of the sperm morphology (5%) in vivo was consistent with the previous publications in assisted reproduction programmes for sperm morphology.
Clinical assessment of the male fertility
Obstetrics & gynecology science, 2018
The evaluation of infertility in males consists of physical examination and semen analyses. Standardized semen analyses depend on the descriptive analysis of sperm motility, morphology, and concentration, with a threshold level that must be surpassed to be considered a fertile spermatozoon. Nonetheless, these conventional parameters are not satisfactory for clinicians since 25% of infertility cases worldwide remain unexplained. Therefore, newer tests methods have been established to investigate sperm physiology and functions by monitoring characteristics such as motility, capacitation, the acrosome reaction, reactive oxygen species, sperm DNA damage, chromatin structure, zona pellucida binding, and sperm-oocyte fusion. After the introduction of intracytoplasmic sperm injection technique, sperm maturity, morphology, and aneuploidy conditions have gotten more attention for investigating unexplained male infertility. In the present article, recent advancements in research regarding the...
Significance of sperm characteristics in the evaluation of male infertility
Fertility and Sterility, 2006
Objective: To compare sperm characteristics among: patients undergoing infertility evaluation, patients with male factor infertility (MFI), healthy sperm donors, and men with proven fertility; to examine the overlap of sperm characteristics in all four of these groups; and to identify good discriminators of fertility versus infertility among sperm characteristics. Design: Retrospective study. Setting: Male infertility clinic at a tertiary care hospital. Patient(s): Proven fertile men (n ϭ 56), normal donors (n ϭ 91), men presenting for infertility evaluation (n ϭ 406), and MFI patients (n ϭ 166). Intervention(s): None. Main Outcome Measure(s): Routine semen analysis. Result(s): Using current World Health Organization (WHO) reference values, a large group of MFI patients presented with higher sperm concentration (27.5 ϫ 10 6 to 99.2 ϫ 10 6 ), resulting in broader overlap with fertile men and poor sensitivity (0.48).
International Journal of Infertility & Fetal Medicine
The WHO estimates that in 50% of couples with infertility issues, the male factor isolated is found in 30% of cases and in combination with female factors in 20%. 1-5 In the last decades, several studies have described a substantial decline in sperm counts, namely one systematic review that claimed a decrease of 50-60% (1973-2011). 3 In fact, over 90% of male infertility is due to poor sperm quality, low sperm counts, or these two concomitantly. 2 Various conditions can account for male infertility, namely anatomical defects, genetic abnormalities, systemic diseases, infections, gonadotoxins, and trauma, among others. 5 Among genetic causes, chromosomal abnormalities can deteriorate testicular function, and Y chromosome microdeletions are responsible for isolated spermatogenic defects. 3 Some childhood events (testicular trauma or torsion) or congenital defects like cryptorchidism may also contribute to the fertility issue. 3 Varicocele is one of the main causes, being present in 40% of infertile men. 1,3,6 Nevertheless, the literature reports a significant number of cases in which no cause is identified, ranging from 30 to 40%, and thus classified as idiopathic. 1,5 Oxidative stress affects 37 million infertile men. 3 Exposure to environmental chemicals and toxic consumption