A higher prevalence of migraine in patients with cardiac syndrome x compared to patients with cardiovascular disease and healthy control (original) (raw)

Background Cardiac syndrome X(CSX), is a type of ischemic heart disease, that is characterized by angina-like chest pain, without any evidence of signi cant coronary vascular abnormalities. Some evidence has revealed a signi cant association between migraines, particularly migraine with aura, with cardiovascular diseases (CVDs). In this case-control study, the prevalence of migraine and the role associated risk factors were compared between the patients with CSX, CVD, and healthy control individuals. Methods The patients with CSX (n = 70), CAD (n = 70), and healthy individuals (n = 70) were enrolled in this study. For each enrolled subject, demographic and clinical data were collected. The prevalence of migraine and associated risk factors were determined in each group. Results The prevalence of migraine in the CSX group (40%) was signi cantly higher compared to those of CVD (24%) (p = 0.047) and healthy controls groups (21%) (p = 0.017). In the control subjects, but not in the CVD and CSX groups, the female gender was a signi cant risk factor for migraine. The prevalence of migraine with aura was signi cantly higher in patients with CSX (20%) compared to patients with CVD (8%) (p = 0.045). The family history of migraine was signi cantly higher in patients with CSX (57.0%) compared to patients with CVD (31.0%) and the control group (35.7%) (p = 0.004). Conclusions The results of this study revealed a signi cantly higher prevalence of migraine in patients with CSX. The ndings also showed a familial aggregation of migraine in the patients with CSX, suggesting a role of genetic factors in predisposing CSX patients to migraine.