Phenome-Wide Search of Cognitive Reserve Proxies Across Age Cohorts (original) (raw)
Cognitive reserve (CR) refers to adaptability allowing for better cognitive outcomes given the degree of brain changes or other risk factors for cognitive decline. Despite significant research efforts, our knowledge of cognitive reserve proxies remains limited. Studies predominantly use a single sociodemographic variable (e.g., education attainment) as a proxy measure when CR can manifest in multiple domains. Studies also tend to rely on older samples, whereas adversity factors of cognitive performance may have differing onset ages, suggesting different risk or protective mechanisms at different ages. We examine two cohort datasets spanning from early adolescence (Adolescent Brain Cognitive Development study, N = 5559) up to the cusp of mid-adulthood (Colorado Adoption/Twin Study of Lifespan behavioral development and cognitive aging; CATSLife, N = 1327) to evaluate the role of CR proxies across over 100 variables. Defined as a moderator between a cognitive outcome and structural br...
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