Review on Substituted 1,3,4-OXADIAZOLE and Its Biological Activities (original) (raw)

3,4-Oxadiazole: A New Profile of Biological Activities

2014

The small and simple 1,3,4-oxadiazole nucleus is present in compounds involved in research aimed at evaluating new products that possess interesting biological activities, such as antimicrobial, antitumor, anticonvulsant, antiviral, analgesic and antiinflammatory. The present review focuses on the 1,3,4-oxadiazole with potential activities that are now in development. INTRODUCTION: 1,3,4-Oxadiazoles are unicyclic ring system which found to have diverse chemical reactivity and broad spectrum of biological activity. Although they have been known from long ago to be biologically active, their varied biological features are still of great scientific interest. 1,3,4-oxadiazole show antitumor activity, especially the phenyl-substituted 1,3,4-oxadiazole 1-2 , while phenacyl-1,3,4-oxadiazole exert ulcerogenic activity 3. Recently, Zheng Li et al. 4 have described the synthesis of 2-(3-methylbenzoylamino)-5-aryloxymethyl-1,3,4oxadiazoles as potential monoamine oxidase inhibitor. Given below is a brief account of various alterations conducted on 1,3,4-oxadiazole ring and their associated biological activities. ANTIMICROBIAL ACTIVITY: 1,3,4-oxadiazole show a wide spectrum of antimicrobial activity and a considerable amount of work has been done on the synthesis of new potent antibacterial and antifungal 1,3,4-oxadiazoles. Khanum, S.A. et al 5 , prepared some new 5-(2-aroylaryloxy)methyl-1,3,4-oxadiazole-2-(3H)thiones (1) and screened them for their antibacterial activity against E.coli, B.subtilis, P.fluorescens, P.solanacearum, and for their antifungal activity against C.albicans, C.krusei, C.parapsilosis, A.flavus, A.ochraceous, F.moniliforme. The antifungal screening results have been shown that the halo substituted compounds exhibit significant activity. In case of antibacterial activity all the compounds have shown higher activity.

A Review on Substituted 1,3,4-Oxadiazole and its Biological Activities

2020

Oxadiazole a five-member heterocyclic aromatic organic compound. It is an important Pharmacophore and privileged structure in medicinal chemistry. The derivative of oxadiazole nuclei (1,3,4-oxadiazole) showed diverse biological activities such as anti-microbial, anti-bacterial, anti-tubercular, anti-fungal, anti-cancer, anti-HIV. In this article, we have tried to compile some of the major researches carried out for the compound 1, 3, 4-oxadiazole.