Serum Levels of 25-Hydroxy Vitamin D in Patients With Moderate and Severe Erectile Dysfunction (original) (raw)
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Prospective Study of Predictors of Vitamin D Status and Cancer Incidence and Mortality in Men
2006
Background: Vitamin D has potent anticancer properties, especially against digestive-system cancers. Many human studies have used geographic residence as a marker of solar ultraviolet B and hence vitamin D exposure. Here, we considered multiple determinants of vitamin D exposure (dietary and supplementary vitamin D, skin pigmentation, adiposity, geographic residence, and leisure-time physical activity -to estimate sunlight exposure) in relation to cancer risk in the Health Professionals Follow-Up Study. Methods: Among 1095 men of this cohort, we quantifi ed the relation of these six determinants to plasma 25-hydroxy-vitamin D [25(OH)D] level by use of a multiple linear regression model. We used results from the model to compute a predicted 25(OH)D level for each of 47 800 men in the cohort based on these charac teristics. We then prospectively examined this variable in relation to cancer risk with multivariable Cox proportional hazards models. Results: From 1986 through January 31, 2000, we documented 4286 incident cancers (excluding organ-confi ned prostate cancer and nonmelanoma skin cancer) and 2025 deaths from cancer. From multivariable models, an increment of 25 nmol/L in predicted 25(OH)D level was associated with a 17% reduction in total cancer incidence (multivariable relative risk [RR] = 0.83, 95% confi dence interval [CI] = 0.74 to 0.92), a 29% reduction in total cancer mortality (RR = 0.71, 95% CI = 0.60 to 0.83), and a 45% reduction in digestive-system cancer mortality (RR = 0.55, 95% CI = 0.41 to 0.74). The absolute annual rate of total cancer was 758 per 100 000 men in the bottom decile of predicted 25(OH)D and 674 per 100 000 men for the top decile; these respective rates were 326 per 100 000 and 277 per 100 000 for total cancer mortality and 128 per 100 000 and 78 per 100 000 for digestive-system cancer mortality. Results were similar when we controlled further for body mass index or physical activity level. Conclusions: Low levels of vitamin D may be associated with increased cancer incidence and mortality in men, particularly for digestivesystem cancers. The vitamin D supplementation necessary to achieve a 25(OH)D increment of 25 nmol/L may be at least 1500 IU/day. [J Natl Cancer Inst 2006;98:451 -9] S UBJECTS AND M ETHODS
VITAMIN D STATUS IN A RANDOM POPULATION: A COMPARATIVE STUDY BETWEEN MALES AND FEMALES
Abstract-. Vitamin D deficiency is a well-known cause of rickets in children, osteomalacia and osteoporosis in adults. Worldwide, an estimated one billion people have inadequate levels of vitamin D in their blood, and deficiencies can be found in all ethnicities and age groups. Objective: The present study is a retrospective study and the objective is to compare the status of Vitamin D in a random population attending to a tertiary care hospital. Materials & methods: The study included a sample size of 320 subjects. Out of this 160 were male subjects and 160 were female subjects of age groups 20-75 years. Population above 75 years and below 20 years are excluded from the study. The vitamin D levels were compared seperately in females including 100 subjects, criteria being pre-menopause and post-menopause. 100 male subjects were compared with age above and below 50 years. Results: It is observed a higher prevalence of vitamin D deficiency is seen in general population, and deficiency being higher in females when compared to males (p<0.0001, r=0.100). No significant correlation was observed between males of above and below 50 years in this study (p=0.45, r=0.100). In females the prevalance of Vitamin D deficiency is found to be significantly higher in pre-menopausal than post-menopausal females (p<0.0001, r=0.170). Conclusion: The serum 25(OH)D concentration is the best indicator for vitamin D deficiency, insufficiency, sufficiency, and toxicity. There is a high prevalence of vitamin D deficiency and insufficiency, even in normal populations, and there is growing evidence for the contribution of low circulating 25(OH)D levels to the development of a wide range of chronic diseases. Keywords: Vitamin D; Osteoporosis; Random population; Vitamin D deficiency
Prevalence of vitamin D deficiency in early-diagnosed cancer patients: A cross-sectional study
Annals of Cancer Research and Therapy, 2020
Background: Vitamin D roles in human health and wellbeing have been extensively studied in the recent years. It has essential roles in homeostasis and maintaining many physiological functions. These roles are vital in immune system, respiratory system, cardiovascular system, and reproductive system. Deficiency in this vitamin has been correlated with many diseases in the body, and it has been correlated with developing cancer. Objective: This study aimed to investigate levels of total vitamin D (25-hydroxycholecalciferol) in cancer patients. Design: Retrospective. Settings: Taif city-king Faisal Hospital (KFH). Patients and methods: Serum levels of 25-hydroxycholecalciferol were classified into normal, insufficient, and deficiency group, patients were grouped according to these classes.156 patients were included in this study, 128 females and 28 males, 100 healthy participants were included. Cancer patients were as follows, gastrointestinal tract cancer patients were 27, breast cancer patients were 73, female genital tract patients were 43, head and neck cancer patients were 6 and respiratory tract patients were 7. Sample size: 256 participants were 100 healthy controls and 156 cancer patients. Results: Deficiency was detected in most of the patients from both genders, and in both pre-and post-menopausal female patients. Conclusion: These findings support the belief that deficiency in vitamin D is a risk factor leading to development of cancer.
Annals of King Edward Medical University, 2009
Background: Vitamin is the important micronutrient that acts like hormone and its deficiency is related to various diseases 1. Limited Data is present for the Pakistani population for vitamin D. Objectives: Assess the vitamin D levels in the patients presenting with different medical conditions and its correlation with symptomatology. Methods: We randomly took 400 patients visiting the outpatient department for the various diseases and complaints. They were asked about various complains, diet, drugs and food fortification. Blood samples for the vitamin D was collected and results were analyzed statistically. They were divided into four grades; Normal (30-100 ng/ml), Mild deficiency (20-29 ng/ml), Severe deficiency (less than 20 ng/ml) and Toxic levels (more than 100 ng/ml).the correlation between vitamin D levels and symptomatology was also calculated. Results: Out of 400 patients, 304 (76%) were female and 96 (24%) were male. Mean value for the vitamin D was 20.70 (for male 20.50 and for female 20.20). Mean value for the age was 45.50. Among 400 subject, 53 (13.25%) had normal values, 80 (20%) had mild deficiency and 264 (66%) had severe deficiency, where as 3 (0.75%) were having toxic levels. The frequency of major symptoms was Generalized body weakness 360 (90%), Bone and joint pains 88 (22%), Diabetes 64 (16%), history of Pathological fracture/falls 45 (11.25%), Depression/anxiety 240 (60%), Blood pressure 132 (33%), Hair loss 8 (02%), Shortness of Breath 60 (15%), Ch. Diarrhea 40 (10%), Weight loss 40 (10%), Fever 20 (5%). Almost all patients having severe deficiency were symptomatic 262 (99.2%). Conclusion: Pakistani Urban, Well feed population is grossly deficient of vitamin D and majority of patients with severe deficiency are symptomatic.
Vitamin -D Deficiency: A Clinical Problem Searching For Solution
Journal of Advanced Pharmaceutical Science And Technology, 2018
The role that Vitamin D plays in human health is no more hidden in this modern age where every individual carries the knowledge treasure in the pocket (The internet) but the unjustified deficiency or insufficiency is still a research question waiting for the answer from research community all over the world. Normal levels (30-50 ng/ml) are necessary for the development of teeth and bones in children and bone mineralization in adults. The deficiency or insufficiency causes rickets, arthralgia, arthritis, osteoporosis and Osteomalacia.
Low Serum 25-hydroxyvitamin D Levels in Oral Cancer Patients
2021
Vitamin D is thought to have a protective role in cancer formation and development. The study aimed was to evaluate the serum 25-hydroxyvitamin D (25(OH)D) levels and their relationship with cancer stage in a cross-sectional study among oral cancer patients. Oral cancer was clinically diagnosed and confirmed by histopathological examination. Serum 25(OH)D levels were measured using Human 25-Dihydroxy-vitamin D ELISA Kit. Sixty subjects were enrolled in this study, 30 oral cancer patients (66,7% women and 33,3% men) and 30 healthy control subjects (66,7% women and 33,33% men). The mean age of the oral cancer patients was 52 + 14 years from a range of 19-78 years and the healthy control group was 34 years + 9 years from a range of 23-55 years. 61,5% of oral cancer patients had 25(OH)D deficiency. Serum 25(OH)D levels in oral cancer patients (16.83 ng/mL) were significantly lower (p<0.05) compared to the healthy controls (62.90 ng/mL). Bivariate analysis revealed no significant rela...
Salivary vitamin D levels among OSCC and normal Indian patients
Bioinformation, 2022
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Studies of Vitamin D Deficiency in Man
QJM: An International Journal of Medicine, 1975
Highly sensitive assays have been developed that enable 25-hydroxycholecalciferol (25-hydroxyvitamin D 3) and 25-hydroxyergocalciferol (25-hydroxyvitamin D 2) to be measured in the same serum sample. With these assays it has been shown that endogenously produced cholecalciferol (vitamin D 3) is important in man; the findings further emphasize the role of vitamin D metabolites as hormones rather than vitamins in the traditional sense. Dietary sources of vitamin D appear to be inadequate and vitamin D deficiency has been shown to be the cause of rickets and osteomalacia in Asian immigrants to Britain. This condition may be readily treated with small doses of vitamin D. In addition, sub-clinical deficiency was found in the Asian community. In the elderly, also, vitamin D deficiency was established as an important cause of osteomalacia and again evidence for the existence of a sub-clinical deficiency state was found. It is therefore suggested that the present prophylactic practices should be reviewed. Secondary hyperparathyroidism (reflected by elevated concentrations of circulating immunoassayable parathyroid hormone) was shown to be the rule rather than the exception in vitamin D deficiency. Some patients, however, had failed to respond to a hypocalcaemic stimulus. In others, there were high concentrations of parathyroid hormone despite normal serum calcium concentrations. Thus the relationship between parathyroid hormone and metabolites of vitamin D may not be mediated through changes in serum calcium alone, and it is postulated that metabolites of vitamin D m"ay directly affect the secretion of parathyroid hormone.