Ameloblastic carcinoma of the maxilla: A rare case presentation and a review of new cases (original) (raw)
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Ameloblastic carcinoma of the maxilla: a report of two cases and a review of the literature
Journal of the Korean Association of Oral and Maxillofacial Surgeons, 2016
cancers arising from the odontogenic epithelium 5. However, there was no provision for AC or similar lesions 5. In 1983, Shafer et al. 6 introduced the term 'ameloblastic carcinoma' to describe a malignant epithelial odontogenic tumor that histologically retains the features of ameloblastic differentiation and exhibits cytological features of malignancy in a primary or recurrent tumor. In the most recent classification by the WHO, odontogenic carcinomas include metastasizing ameloblastoma, AC, primary intraosseous carcinoma, ghost cell odontogenic carcinoma, and clear cell odontogenic carcinoma 7. ACs meeting WHO criteria might arise as a result of malignant changes in a preexisting benign ameloblastoma (secondary type) or might develop de novo as a primary AC. This tumor exhibits malignant histopathological features independent of the presence of metastasis 8 , whereas malignant ameloblastomas metastasize with well differentiated benign cells 9. According to Kruse et al. 10 , most cases (67%) of AC are located in the mandible, with the rest occurring in the maxilla. In their evidence-based review of cases occurring over 60 years, they found only 27 maxillary cases of AC, which CASE REPORT
Ameloblastic carcinoma of the maxilla: a report of 3 cases
Journal of Cranio-maxillofacial Surgery, 1998
Odontogenic carcinomas of the maxilla are classified as malignant ameloblastoma, ameloblastic carcinoma or primary intraosseous carcinoma. The term 'ameloblastic carcinoma' is used to describe those ameloblastomas in which there is histological evidence of malignancy in the primary, recurrent or metastatic tumour. Three cases of ameloblastic carcinoma with an unusual location in the maxilla are presented here. Histologically, the lesions were characterized by typical zones of ameloblastoma as well as zones with anaplastic transformation. The authors review the literature describing the clinical and histological presentation and the treatment of this rare turnout.
Ameloblastic carcinoma of maxilla
National Journal of Maxillofacial Surgery, 2012
This study aims to present the clinical features and treatment of a case of maxillary ameloblastic carcinoma. Ameloblastic carcinoma is a rare malignant odontogenic carcinoma that has metastatic potential. Due to its rare incidence, there are few studies focusing on its radiological characteristics. When ameloblastic carcinoma demonstrates an aggressive appearance, it may be diagnosed as a malignant tumor; however, in cases showing a non-aggressive appearance, it is difficult to distinguish ameloblastic carcinoma from ameloblastoma. We report a case of ameloblastic carcinoma of the maxilla in a 59-year-old male patient, including the clinical signs, radiological images and pathological features. A partial area was surgically excised under local anesthesia and the material was sent to the Laboratory of Oral Pathology. The histological sections revealed a fragmented odontogenic tumor of epithelial origin, consisting of solid parenchyma and also revealed basal cells resembling ameloblasts, occasionally arranged in palisades. Certain parts of the architecture resembled that of an ameloblastoma; however, the cytology of other areas confirmed the diagnosis of ameloblastic carcinoma of the maxilla. The patient was scheduled for definitive surgery, including a right maxillectomy and radiotherapy. The patient was followed up every 3 months. After 2 years follow-up, there were no clinical or radiological signs of recurrence.
Ameloblastic carcinoma of the maxilla
Journal of Maxillofacial Surgery, 1986
A case of an ameloblastic carcinoma in an unusual situation in the maxilla is presented. The lesion is characterized histologically by areas with features of a typical ameloblastoma and areas with anaplastic transformation. A Caldwell-Luc operation was followed by a recurrence after 3 years. Due to the advanced age and poor general health of the patient an enlarged, but not radical operation was performed. There is no evidence of metastatic tumour.
Annals of Maxillofacial Surgery, 2014
Ameloblastic carcinoma (AC) is a rare primary odontogenic tumor that has histological features of both ameloblastoma and carcinoma. A total number of 92 case reports speak about its rare incidence, affecting mostly the mandible as a locally destructive lesion. The maxilla is affected even more rarely as only 35 cases have been reported until 2012 in scientific literature. The clinical course of AC is generally aggressive, with extensive local bone destruction. The most common clinical features include swelling, pain, trismus, significant bone resorption with tooth mobility, dysphonia and intraoral fistula. We report two cases of AC with aggressive behavior.
Literature review of 86 cases of mandibular ameloblastic carcinoma
National journal of maxillofacial surgery
Ameloblastic carcinoma is considered to be a rare epithelial malignant neoplasm of odontogenic origin occurring mainly in the mandible. Ameloblastic carcinoma has been a topic of controversy regarding management from past many years. We reviewed 86 cases of mandibular ameloblastic carcinoma from 1981 to 2014, on the basis of the electronic search of peer-reviewed journals in MEDLINE (PubMed) database. Age, sex, tumor size, treatment delivered, recurrence, metastasis, follow-up period, and dead/alive status are tabulated, and the data are analyzed. The mean age was 43.47 years with standard deviation ± 21.09. The age range was between 15 and 91 years, and male to female ratio was 2.18:1. Knowledge gained from the present review would help in establishing the best therapeutic options for ameloblastic carcinoma, and it also encourages the further reporting of ameloblastic carcinoma.
Ameloblastic carcinoma of mandible: Report of intriguing presentation
Basic and Applied Pathology, 2012
Ameloblastic carcinoma, a rare aggressive odontogenic tumor occurs predominantly in the mandibular posterior region. Clinical symptoms are varied with possible metastasis to the regional lymph nodes or lung. Radiographically, it usually manifests as an ill-defined osteolytic radiolucency. Histologically, it resembles ameloblastoma that is mostly devoid of its familiar microscopic features in combination with prominent cytological atypia and mitotic activity. A rare and atypical presentation of ameloblastic carcinoma of the mandible with unconventional clinical and radiological features is documented in this case report.
Ameloblastic carcinoma of the mandible: A case report and review of the literature
Médecine Buccale Chirurgie Buccale
The purpose of this paper was to report an additional case of ameloblastic carcinoma of the left hemi-mandible and to review and analyze clinical, radiological and histopathologic features, treatment modalities and prognosis. Presentation of case: A 70 year old malepatient presented to Maxillofacial Department for a painful swelling of the left cheek. An ameloblastic carcinoma of the left hemi-mandible was diagnosed. He underwent radical surgical intervention comprising hemimandibulectomy, supraomohyoid neck dissection, and fibula free-flap reconstruction. Postoperative radiotherapy was employed. Discussion: Ameloblastic carcinoma of the mandible is a rare aggressive tumor with a poor prognosis. It can be seen in different ages. The most common symptom is a rapidly progressing painful swelling. It is defined as a malignant epithelial odontogenic tumor that retains the features of ameloblastic differentiation with cytologic features of malignancy. Non therapeutic consensus is established. However, wide surgical excision with radiotherapy is the most common treatment. Conclusion: Diagnosis of ameloblastic carcinoma at early stage and close periodic screening for metastasis are necessary to improve patient prognosis.
2011
Aim: The purpose of this paper was to report an additional case of ameloblastic carcinoma of the left hemi-mandible and to review and analyze clinical, radiological and histopathologic features, treatment modalities and prognosis. Presentation of case: A 70 year old malepatient presented to Maxillofacial Department for a painful swelling of the left cheek. An ameloblastic carcinoma of the left hemi-mandible was diagnosed. He underwent radical surgical intervention comprising hemimandibulectomy, supraomohyoid neck dissection, and fibula free-flap reconstruction. Postoperative radiotherapy was employed. Discussion: Ameloblastic carcinoma of the mandible is a rare aggressive tumor with a poor prognosis. It can be seen in different ages. The most common symptom is a rapidly progressing painful swelling. It is defined as a malignant epithelial odontogenic tumor that retains the features of ameloblastic differentiation with cytologic features of malignancy. Non therapeutic consensus is es...